Now in @cellpress.bsky.social: We profiled cerebrospinal fluid proteomes from 5,000 neurology patients by mass spectrometry — mapping protein changes across stroke, brain cancer, infections & autoimmune diseases, revealing shared and disease-specific signatures.
www.sciencedirect.com/science/arti...
MSACL moving to Montreal was a great move in hindsight.
Scientist role at Lilly developing and validating mass spectrometry based biomarkers to support clinical trials in Alzheimers Parkinsons ALS and rare brain disorders.
www.dementiaresearcher.nihr.ac.uk/job/advisor-...
Ah that’s annoying
The best and durable companies consider all main stakeholders including customers, employees and shareholders.
Turkiye used to be one of the very few OECD countries Canada could beat on R&D spending. No longer.
Looking forward to reading it.
I’m glad. A lot of successful IP-MS assays we have heavily relies on internal antibodies.
Congratulations!
Can I upgrade my 480 to Excedion?😜
I run it at 0.8 uL/min with 50C heating and the pressure is at 600 bar. I also commonly use it at 0.4uL/min, off the top of my head it is at around 350-400 bar. 1000 bar if I run it at 1.3 uL/min.
I like seeing proteomics folks picking up CLSI C64.
Recently got a TQ absolute. Will report back once we start running samples with Ionkey. We mostly run plasma and CSF samples.
Post-transcriptional regulation and post-translation modifications explains big part of the missing correlation?
This is indeed quite exciting. Very much looking forward to it.
Thyroglobulin is a famous one. To be honest, there are not many. Unlike ELISA where GMP quality labs produce kits to ensure assay maintenance, I think it’s challenging to maintain a mass spec protein biomarker in the clinic with the labs being the developer and manufacturers at the same time.
This podcast episode touched on this point you mentioned open.spotify.com/episode/16Yh...
Rapizyme is pretty awesome. Highly pure, heat resistant.
Rapizyme maybe able to replace out trypsin+ProteaseMax to be honest if you want it simple.
To the last point: This the FDR discussion?🤣
