Rhys Allan

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize...

1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. www.cell.com/molecular-ce...

If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️
We are looking for a postdoc to join our team at @imbavienna.bsky.social
More details 👇🏻

Finally, today's offering! www.biorxiv.org/content/10.6...

This began life as a very different project which failed because we couldn't agree on defining eqtl sharing across cohorts. So two young members of the lab dug deeply into this - first @ijbeasley.bsky.social, then @patrickgibbs.bsky.social

Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar.
Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse.
www.biorxiv.org/content/10.6...

Decoding the molecular logic of rapidly evolving ZAD zinc finger proteins in Drosophila Identification of ZAD-ZnF genes as key regulators of genome organization during Drosophila embryogenesis.

Diving into evolutionary biology! What is the origin of the most abundant class of insect transcription factors, ZAD-ZnFs? We suggest that they evolved from ancestral insulator-binding proteins that control 3D genome topology.

www.science.org/doi/10.1126/...

New pre-print identifying 29 Covid GWAS variants that drive allele-specific activity in a functional genomics screen in lung cells, from @gweykopf.bsky.social and
@eliasfriman.bsky.social @simonbiddie.bsky.social

www.biorxiv.org/content/10.6...

@uoe-igc.bsky.social
@uk-fgx.bsky.social

We wrote a piece on how easy it is to write gene regulatory sequences. - Turns out, it isn't that easy even though we know a lot about cis-regulation.

huge credit to @carldeboer.bsky.social to seeing this through so our thoughts aren't lost. I promise, it's a worthwhile read!

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🚨 We’re happy to announce (finally!) the publication of METALoci, in collaboration with @dariloops.bsky.social and heroes: @jrotwitguez.bsky.social & @imotagom.bsky.social.

METALoci integrates #3DGenome and #Epigenetics data into a unified framework we believe is very useful!

Here 👉🏻 rdcu.be/e5sm2

Fellowship application dealdine for students from low income countries 🌐will be in 1️⃣ week.
Dont miss out on this opportunity ! Hands on Summer School.
Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➡️Unique opportunity ! 15 exiting days ➕ Daily high profile lectures.
👉 bit.ly/4oGDR8f

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - Nature Biotechnology Trimodal single-cell analysis reveals gene-regulatory architecture in complex tissues.

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - @yaruidiao.bsky.social @dukehealth.bsky.social go.nature.com/4rZqimf

Review: @stjude.bsky.social @cp-molcell.bsky.social
Density transitions in the regulation of transcription
www.cell.com/molecular-ce...

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation:
www.sciencedirect.com/science/arti...

That's a wrap for Lorne Genome 2026! Thanks to all the speakers for fascinating talks, poster presenters for hot of the press science, trade for making the experiments possible and of course all the attendees for great discussion. See you next year!

TCF1 is a master regulator of T cell stemness – but can it make exhausted cells go backwards?

We setup a CRISPR KI system to ask this question, and the answer was unexpected.

www.nature.com/articles/s41...

Congratulations to winners of the Lorne Genome Best Student Poster Prizes: Jessica Hawes, Sarah Berent, David Neville, Sandeep Kum and Andrea Daner!

Last day of #Lornegenome. A great venue, cool talks and discussions. Learnt about diversification of mammalian genomes, inheritance of mutations and impact of mutagens, how TFs direct chromatin organisation and so much more. New collaborations, new projects, can’t wait til next year

2026 Winner of the Lorne Genome Julian Wells Medal: Christine Wells (no relation!) @stemcellsystems.bsky.social congratulations, well deserved!!

Hi yes I will have more to say about this in a few hours but please enjoy this paper. It's been a huge labour of love and effort for the last four years, and a significant part of our research efforts, and I'm so so so thrilled it's finally ready to share.

Tldr: scRNA-seq in Indonesia hard but fun

So excited to have this study live! Lead by @ee-reh-neh.bsky.social's teram and in collaboration with an incredible team at MRIN in Indonesia. This is the culmination of ~5 years of work including a ton of effort in the field. Really proud of how this came together!

www.biorxiv.org/content/10.6...

We’ve been spoiled with lovely weather & quality science at @lornegenome.bsky.social this year, continuing this morning with Session 11 (Novel Approaches to Study the Genome) & then the Julian Wells Medallist presentation. Hope everyone has rested up after the dinner! See you 9am! #LorneGenome2026

Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation @natgenet.nature.com @tessapopay.bsky.social @jessedixon.bsky.social @salkinstitute.bsky.social
www.nature.com/articles/s41...

Lorne Genome Conference dinner with a few party crashers

Alex Hewitt @utas.edu.au takes #lornegenome through genetic drivers of glaucoma, making use of large biobanks, showing high predictive rates for glaucoma polygenic risk scores compared to other common diseases.

Choose your own adventure @lornegenome.bsky.social Duncan Odom www.lifepi-hd.com/duncan-odom asks if we want greatest hits or new hot stuff - role on hot stuff!

Duncan Odom takes #lornegenome on a wild ride through lesion segregation showing repair of DNA damage can be strand resolved.

Good morning @lornegenome.bsky.social delegates! In case you missed watching the sunrise on the beach this morning (with galahs!), I’m happy to report that today we have a forecast of blue skies, highs of 31 degrees & some great science, kicking off with @odomlab.bsky.social at 9am. #LorneGenome2026

Alex Hewitt @utas.edu.au speaking about spatial transcriptome analysis of glaucoma @lornegenome.bsky.social @biorxivpreprint.bsky.social doi.org/10.1101/2025...

Up now @hannah-coughlan.bsky.social Hannah Coughlan of @wehi-research.bsky.social #Lornegenome Millenium Prize Winner talking about her work on the 3D organisation of the genome in immune cells

Vanessa Hayes taking us through African genetic diversity - a bottleneck was caused when populations migrated out of Africa, but sequencing efforts have focused on European and American genomes, leaving Southern Africa under-represented, causing a knowledge gap for diseases affecting African pops.

We are welcoming Elizabeth Murchison @lizmurison.bsky.social back to Australia to talk about local scourge, transmissible tassie devil cancer, causing facial tumours that threaten survival of the species