Leon Schulte

Tuesday 25.11 13:00 CET we are happy to host Prof. Leon Schulte (rna-lab.org) @schultelab.bsky.social join us for an exciting talk "Multi-omic Dissection of Regulatory lncRNA-Protein Networks in Innate Immunity" thanks @rnasociety.bsky.social @imbb-forth.bsky.social us02web.zoom.us/meeting/regi...

Our latest study is now out in @narjournal.bsky.social‬: we identify a post-transcriptional bottleneck in interferon gamma signaling that hinges on proper maturation of JAK2 mRNA.
Paper: academic.oup.com/nar/article/...

A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages Nature Communications - Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform...

How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications!
🔗 rdcu.be/em7aM

#lncRNA #macrophage #immunology

We also built SMyLR, a searchable online resource for the immune-lncRNA community:

Explore pathway dependencies, subcellular localization, and protein interactors of hundreds of lncRNAs in macrophages:
🔍 rna-lab.org/smylr/

More info in our paper:
🔗 rdcu.be/em7aM

#lncRNA #openscience #macrophage

Meet GRADR: our new approach to chart lncRNA–protein interactions transcriptome-wide.

By combining gradient profiling and RNA-binding proteomics, GRADR reveals which lncRNAs engage which protein machineries.

📘 Step-by-step protocol included in:
🔗 www.nature.com/articles/s41...

#lncRNA #methods

We’re now on Bluesky!
This space will share updates from our lab, covering RNA biology, macrophage immunology, and long noncoding RNAs.
Follow along for papers, resources & insights from the bench.

#lncRNA #macrophage #immunology #RNA #biomed #openscience