Birsen G. Ozamrak, MD

Exudative GN

Abundant endocapillary neutrophils

C3 dominant granular staining pattern

Subepithelial humps

Young pt with h/o strep pharyngitis p/w several days malaise, abd pain, & oliguria w dark brown urine

Acute post-step/post-infectious GN
LM: Exudative GN,
IF: C3-dominant "starry sky" & "garland" pattern
EM: Hump-like subepithelial deposits (blue arrows)
#renalpath #pathsky #nephsky #medsky

Genetic Loss of HIF-Prolyl-Hydroxylase 1, but Not Pharmacological Inhibition, Mitigates Hepatic Fibrosis Liver fibrosis is characterized by excessive deposition of extracellular matrix due to chronic inflammation of the liver. Hepatic stellate cells (HSCs) become activated and produce increased amounts o...

Genetic Loss of HIF-Prolyl-Hydroxylase 1, but Not Pharmacological Inhibition, Mitigates Hepatic Fibrosis. Authors from @uniheidelberg.bsky.social and @jlugiessen.bsky.social.

Full text: ajp.amjpathol.org/article/S000...

TFE3

#PathSky 43F with a solitary lung mass. Relatively circumscribed, nests and interesting micropapillae of lightly eosinophilic epithelioid cells. Negative for everything except TFE3. Dx?

#PathSky Abdominal wall mall mass, 65M. Multinodular with thick fibrous septa. Bland spindled to ovoid cells surrounding prominent vessels. Microcystic, pseudoglandular spaces.

Another social media platform to follow, yeey (!) 🫠😅