Bárbara Bruna Jara

Central neurons encode interleukin-1β signals and mediate stress-induced inflammation url: rupress.org/jem/article/...

Immunity in Alzheimer’s disease: From mechanisms to therapies @cp-immunity.bsky.social www.cell.com/immunity/ful...

Single enzyme found to control formation of immune cells critical for health A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health found that an enzyme involved in protein translation is essential for circulating immune cells, called monocytes, to mature into tissue-resident macrophages, a specialized population of immune cells that maintain organ health by clearing dead cells and debris.

A single enzyme, DHPS, has been identified as essential for the maturation and long-term survival of tissue-resident macrophages, impacting immune function and tissue health across multiple organs. doi.org/hbkvzw

Five minutes more exercise and 30 minutes less sitting could help millions live longer Research finds minor changes in physical activity could hugely reduce number of premature deaths Just five extra minutes of exercise and half an hour less sitting time each day could help millions of people live longer, according to research highlighting the potentially huge population benefits of making even tiny lifestyle changes. Until now, evidence about reducing the number of premature deaths assumed that everyone must meet specific targets, overlooking the positives of even minor increases in physical activity. Continue reading...

Five minutes more exercise and 30 minutes less sitting could help millions live longer

Graphic depicting the pathway of sensory nerves coordinating bone fracture repair. K. HOLOSKI/SCIENCE

I've never broken a bone (*knocks on wood*), but I hear it's excruciating. Perhaps its some comfort that the neurons responsible for that pain also help the bone heal? That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪 🦴

The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease - Nature Metabolism Bolaños and Magistretti illustrate how intercellular metabolic cooperation underpins brain function and provide examples of how disruption of the neuron–astrocyte metabolic unit contributes to diseases of the nervous system.

REVIEW | @bolanosjuanp.bsky.social & P Magistretti (U Salamanca, KAUST)

How intercellular metabolic cooperation affects brain function, with focus on the neuron-astrocyte metabolic unit🧪

This is Extended Data Figure 2. It shows the basic properties of the optoelectronic capsule used in this study.

A paper in Nature Microbiology reports a smartphone-controlled ingestible capsule that can control and allow for two-way communication with gut bacteria in pigs. The findings could lay the foundation for new diagnostic and treatment strategies for diseases. go.nature.com/44P2OI2 #medsky 🧪

Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition BACKGROUND Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. However, there is currently no clinical evidence demonstrating the .....

Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition - Smith - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

V meeting of CICAs (Advanced clinical research centres) @uchile.bsky.social sharing the different research lines with translational focus #translationalScience

Mind over microbiota: neurons call the shots in the gut - Nature Metabolism Although the gut microbiota can influence brain function, evidence for brain activity-driven changes in microbial communities is limited. Here, the authors provide direct support for bidirectional com...

www.nature.com/articles/s42...

Eating just 10% more ultraprocessed food ups your risk of premature death from any cause by nearly 3%, a new study says. cnn.it/3REUUJR

🗞️Our April issue is live!📷
We're featuring work on immune aging, oligodendrocytes in aging & disease, single-cell resources, and news about exciting initiatives involved in biomarker development, geroscience, and autophagy research.

Read it all here 👇
www.nature.com/nataging/vol...

A short-term, high-caloric diet has prolonged effects on brain insulin action in men - Nature Metabolism Short-term overeating with calorie-rich snacks is shown to disrupt insulin action in the brain of men, which outlasted the time-frame of overeating.

In a small study of healthy men, brief intake of high calorie sweet and fatty foods disrupted brain insulin action and led to liver fat accumulation for a prolonged period
www.nature.com/articles/s42...

Immune cells in pituitary gland help balance hormones, researchers discover In a new study published in Cell Reports, Finnish researchers show that pituitary macrophages, the immune cells located in the pituitary gland, help regulate hormonal balance.

Immune cells in the pituitary gland, known as macrophages, play a crucial role in regulating hormone balance, potentially offering new avenues for treating endocrine disorders. doi.org/g85dpt

A man was destined for early Alzheimer’s ― these genes might explain his escape Scientists identify nine genetic variants that could have helped a man avoid dementia at least two decades longer than expected.

A man was destined for early Alzheimer’s ― these genes might explain his escape
www.nature.com/articles/d41...

International Day of Women and Girls in Science February 11 ⚗️🧪🔬 #IDWGS #IDWGS2025 #InternationalDayOfWomenAndGirlsInScience #HerVoiceInScience #WomenInSTEM #GirlsInStem #WomenInScience #GirlsInScience #GenderEquality #GenderGap

Neural pathway in mice sheds light on how the brain regulates learned immune responses The brain of humans and other animals is known to contribute to the protection of the body from infections. Past studies have unveiled the existence of the so-called conditioned immune response (CIR), which is a form of Pavlovian conditioning that entails the formation of mental associations between specific sensory stimuli (e.g., a specific odor, taste, etc.) and immunomodulatory agents (i.e., a substance that influences the immune system).

A neural pathway in mice has been identified that mediates the retrieval of conditioned immune responses, highlighting the brain's role in linking sensory experiences to immune function. doi.org/g8383h

Microglia reprogramming offers novel strategy to combat melanoma brain metastases Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) in Elche, have identified a strategy to slow their progression, which could improve the response to current treatments.

Reprogramming microglia to block the Rela/NF-kB pathway shows promise in reducing melanoma brain metastases and enhancing immunotherapy efficacy in preclinical models. doi.org/g839r5

Omega-3 supplements slow biological ageing The anti-ageing effect was even greater when combined with vitamin D and exercise.

Taking omega-3 and vitamin D supplements over a three-year period slowed biological ageing by three to four months, particularly when combined with exercise.

https://go.nature.com/4hjjGdO

Retrieval of conditioned immune response in male mice is mediated by an anterior–posterior insula circuit - Nature Neuroscience The authors show that a bidirectional circuit connecting the anterior and posterior (aIC–pIC) insula mediates the conditioned immune response in male mice, illustrating a mechanism by which sensory ex...

Retrieval of conditioned immune response in male mice is mediated by an anterior–posterior insula circuit nature.com/articles/s41...

Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits This study provides one of the most comprehensive immune profiles of elderly individuals, uncovering high-resolution immune changes associated with aging. Our findings highlight clinically relevant im...

An immunome in 550 older adults and young adult controls demonstrated age-related changes at high-resolution along with some unique immune signatures
www.thelancet.com/journals/ebi...

More than 40% of postdocs leave academia, study reveals Nature - Publishing highly cited papers helps postdoctoral researchers to land a faculty job.

More than 40% of postdoctoral researchers leave academia, according to a study of some 45,500 researchers’ careers

https://go.nature.com/3Ej9RxA

The dance of microglia 🕺🏽🪩 microglia (green) around AB plaques (red) in hippocampus of 5xFAD mice #FluorescenceFriday

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease - Nature Neuroscience This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...

Perspective from Michal Schwartz and colleagues:

Monocyte-derived #macrophages act as reinforcements when #microglia fall short in #Alzheimer’s disease 🧪🧠

www.nature.com/articles/s41...

More than 40% of postdocs leave academia, study reveals Publishing highly cited papers helps postdoctoral researchers to land a faculty job.

More than 40% of postdoctoral researchers leave academia, according to a study of some 45,500 researchers’ careers

https://go.nature.com/3EdzX56

Multifunctional hydrogel electronics for closed-loop antiepileptic treatment Hydrogel electronics enables smart antiseizure management by a closed-loop therapeutic system.

This flexible, Utah Array-like device with sensing and drug delivery all in one seems like it will have a lot of applications. What's next?
doi.org/10.1126/scia...
#neuroscience #neuroskyence #ephys #neurotech #MATLAB
I can't find TDT on here yet.

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...

led by Michael Heneka, published in @natrevimmunol.bsky.social today

(MANY more authors listed and linked below)

Gene behind orange fur in cats found at last After 60 years, scientists know why gingers, calicos, and tortoiseshells look the way they do

After 60 years, scientists finally know why ginger, calico, and tortoiseshell #cats look the way they do. scim.ag/3BpxRxY