Joao Pedro Magalhaes

Integrative Proteomic and Metabolomic Signatures of Accelerated PhenoAge in the UK Biobank Aging is accompanied by molecular changes across multiple biological systems that contribute to functional decline and increased disease risk, but the underlying mechanisms and inter-individual variat...

Integrative Proteomic and Metabolomic Signatures of Accelerated PhenoAge in the UK Biobank
www.medrxiv.org/content/10.6...

A hierarchy of causes of death in senescent C. elegans
www.nature.com/articles/s41...

Molecular evolution of animal aging - The EMBO Journal Comparative biology plays a crucial role in uncovering fundamental biological mechanisms and providing evolutionary models for their variation. This approach is particularly valuable for studying agin...

Molecular evolution of animal aging
link.springer.com/article/10.1...

Integrative Proteomic and Metabolomic Signatures of Accelerated PhenoAge in the UK Biobank Aging is accompanied by molecular changes across multiple biological systems that contribute to functional decline and increased disease risk, but the underlying mechanisms and inter-individual variat...

Excited to share our new preprint on multi-omics signatures of accelerated PhenoAge.

By integrating plasma proteomics and metabolomics, we identified pathways associated with faster aging, including immune-inflammatory activity.

www.medrxiv.org/content/10.6...

Support the Human Ageing Genomic Resources Help Joao Pedro Magalhaes raise money to support University of Birmingham

For 20+ years the Human Ageing Genomic Resources (HAGR) have supported ageing research worldwide (200k+ users/year, 1,000+ citations).

After losing UK government funding, we’ve launched a fundraiser to keep HAGR online. Please support or share!

www.justgiving.com/page/human-a...

The Human Ageing Genomic Resources are vital open-source databases on longevity genes and drugs, and animal lifespans. It would be a loss to the field if they go offline due to funding cuts.

See @jpsenescence.bsky.social’s post here for more details and how to support:

Support the Human Ageing Genomic Resources Help Joao Pedro Magalhaes raise money to support University of Birmingham

🚨 The Human Ageing Genomic Resources Are at Risk

For over 20 years, our Human Ageing Genomic Resources (HAGR) have supported ageing and longevity research.

We are raising funds to secure their continuity while we pursue long-term funding.

www.justgiving.com/page/human-a...

A pleasure to visit beautiful Norwich and the @uniofeastanglia.bsky.social

Lovely place and wonderful colleagues. Looking forward to future collaborations!

Cuproptosis and Aging: Molecular Mechanisms and Therapeutic Implications
www.aginganddisease.org/EN/10.14336/...

ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement - Genome Biology Detecting senescent cells from single-cell RNA-seq data remains challenging due to the weak and non-specific expression of canonical markers. Here, we demonstrate that simple expansion of these low-si...

ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement
link.springer.com/article/10.1...

Frontiers | A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives Aging is driven by interconnected genetic, epigenetic, molecular, and physiological processes spanning from unicellular to organismal levels. The surge in hi...

A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives
www.frontiersin.org/journals/agi...

Excited to share our latest paper on the future of AI in biology 🚀🧬

We argue that decoding the genome and modelling gene interactions across space and time (from development to ageing) should be the ultimate goal for building predictive models of human biology.

www.preprints.org/manuscript/2...

Academia is great training for dating because you get so used to rejection.

Epigenetic markers of ageing and cancer risk Epigenetic alterations are an important shared hallmark of ageing and cancer. The development of epigenetic markers of ageing using blood DNA methylat…

Epigenetic markers of ageing and cancer risk
www.sciencedirect.com/science/arti...

Great discussion earlier this week at the Oxford Biohacking Society on ageing biology and where longevity science may be heading.

Thank you for the thoughtful questions and lively debate 🙏

The Ethics Case for Longevity Science Recent advances in biogerontology show that ageing is malleable, opening the possibility of delaying chronic disease and extending healthspan. Ethical…

Excited to share our ethical case for longevity science.

We address concerns about overpopulation, inequality, and loss of meaning, and argue that life extension is ethically grounded in autonomy and the intrinsic value of life.

www.sciencedirect.com/science/arti...

Greenland sharks survive for centuries with diseased hearts A study of the hearts of Greenland sharks has found that the long-lived deep-sea predator has massive accumulations of ageing markers, such as severe scarring, but this doesn't appear to affect their ...

Greenland sharks survive for centuries with diseased hearts
www.newscientist.com/article/2511...

Great piece on the recent study of the heritability of human lifespan, with some of my thoughts.

Frontiers | A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives Aging is driven by interconnected genetic, epigenetic, molecular, and physiological processes spanning from unicellular to organismal levels. The surge in hi...

A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives
www.frontiersin.org/journals/agi...

Pan‐Epigenetic Age Prediction in Mammals Across > 1000 human and mouse epigenomes, histone modifications and DNA methylation undergo coordinated, cross-tissue remodeling at shared genes.

Pan-Epigenetic Age Prediction in Mammals
onlinelibrary.wiley.com/doi/full/10....

The Science of Ageing & the Future of Longevity | Oxford Biohacking Society Recent technological breakthroughs have given strength to the idea that a cure for human aging can eventually be developed. In this talk, Prof Magalhaes will discuss the latest advances in ageing ther...

I'm excited to be speaking in Oxford next week on recent breakthroughs in ageing and what they mean for the future of longevity.

Hosted by the Oxford Biohacking Society
🗓 Tuesday, February 3, at 5:30pm.

Details & registration below 👇
www.oxfordbiohackingsociety.com/event-detail...

Wow, mind-blowing study showing that immune T cells release “telomere Rivers” into circulation after acquiring them from other cells.

In aged mice, telomere Rivers extended lifespan by 17 months (though n = 10), with some mice living nearly 5 years 🤯

Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages
aacrjournals.org/cancerdiscov...

Cellular senescence as a therapeutic target for aging intervention Cellular senescence is a stress-induced cellular state that contributes to tissue dysfunction, chronic inflammation, and a broad range of aging-associ…

Cellular senescence as a therapeutic target for aging intervention
www.sciencedirect.com/science/arti...

Unlocking neuronal health: leveraging C. elegans for drug repurposing studies - Cell Communication and Signaling Cell Communication and Signaling - Aging affects neuronal function, leading to both structural and functional changes in the human brain. The concomitant cognitive decline and neurodegenerative...

Unlocking neuronal health: leveraging C. elegans for drug repurposing studies
link.springer.com/article/10.1...

What the Longest-Lived Animals Can Teach Us About Aging Scientists are looking into the cells of creatures like whales and mole rats to see if they have lessons for humans.

What the World’s Longest-Lived Animals Can Teach Us About Aging
time.com/collections/...

Aging as a multifactorial disorder with two stages | Aging Aging | doi:10.18632/aging.206339. David Gems, Alexander Carver, Yuan Zhao

Aging as a multifactorial disorder with two stages
www.aging-us.com/article/2063...

New single rejuvenation factors 🚀

They used a transcriptional rejuvenation platform, based on replicative ageing, to identify single transcription factors that promote rejuvenation.

They then validated hits in vitro and, for one factor (EZH2), in the liver of aged mice.

Restoring information in aged gene regulatory networks by single knock-ins A hallmark of aging is loss of information in gene regulatory networks. These networks are tightly connected, raising the question of whether information could be restored by perturbing single genes. ...

Restoring information in aged gene regulatory networks by single knock-ins
arxiv.org/abs/2601.04016

Cellular senescence in normal physiology Long associated with aging, senescent cells can promote health and have physiological roles

A reminder that senescent cells can be functional and play important physiological roles.

So, when labs and companies talk about therapies that remove senescent cells, the devil is in the details: how, when, and which senescent cells?

www.science.org/doi/10.1126/...