Manuel Irimia

Molecular #evolution of animal #aging:
A field perspective explores the impact of evolution on aging and offers a multi-angle view on longevity variation across model organisms and environments
link.springer.com/article/10.1...

🚨🧬🚨

We're looking for a specialized Research Assistant to spearhead a project aimed at exploring new RNA therapeutics in diabetes and other metabolic disorders.

Junior or Senior, we're hoping to recruit a highly motivated and self-driven scientist interested in both basic and applied science. 🦄

Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

Today in
@science.org:
We are pleased to present our last work entitled:
"Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis"
by Zumalave et al.
www.science.org/doi/10.1126/...

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.

Great opportunity for 2 bioinformaticians! Come work with us at @melisupf.bsky.social ! 😉

Please RT! 🙏

UPF’s SPLICE-BETA project receives an ERC Proof of Concept Grant to develop a new treatment targeting the root cause of diabetes El projecte obté 150.000 euros del Consell Europeu de Recerca per impulsar un possible tractament capaç de restaurar la funció de les cèl·lules del pàncrees encarregades de produir insulina. Un pas en...

#Transfer
UPF’s SPLICE-BETA project receives an ERC Proof of Concept Grant to develop a new treatment targeting the root cause of #Diabetes

Congrats to the team led by @mirimiam.bsky.social & Jonas Juan cc @erc.europa.eu @upf.edu @prbb.org
tuit.cat/7kLHr

We are delighted to announce that @mirimiam.bsky.social (@melisupf.bsky.social) has been awarded one Proof of Concept Grant to work on RNA splicing therapeutics for beta cell dysfunction and diabetes.

Back in BCN after an great week in Valencia, 1st meeting of #EvoDevOmics network with @mirimiam.bsky.social @anariesgo.bsky.social @evodevogenomeub.bsky.social @patrialvarezcam.bsky.social @jpascualanaya.bsky.social @phylobrain.bsky.social @fany-real.bsky.social @imaeso.bsky.social & Nuria Flames

1st #EvoDevOmics meeting🍊
What a terrific team
@isabelalmudi.bsky.social @mirimiam.bsky.social @anariesgo.bsky.social @patrialvarezcam.bsky.social @jpascualanaya.bsky.social @phylobrain.bsky.social @fany-real.bsky.social Núria🔥 Nacho and more.
What great hosts🥘 @hector-escriva.bsky.social & Steph

Continuum architecture dynamics of vesicle tethering in exocytosis Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

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🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology

Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...

We are looking for a Bioinformatician (both graduate and postdoctoral levels) to join our lab. Please help us spread the word about this opportunity!

Applicants should submit their motivation letter, full CV and academic record to Juan R. Martínez-Morales: jrmarmor@upo.es

Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes Nature Ecology & Evolution - Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms...

Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed José Luis Gomez-Skarmeta: rdcu.be/eXX8l

Exciting news to start the new year! We’re thrilled to see this work finally out in @natecoevo.nature.com, the result of a major collaboration between my lab and the labs of Veronica Hinman and Nacho Maeso, began many years ago with the dear José Luis Gómez-Skarmeta.
www.nature.com/articles/s41...

Open Senior Bioinformatician position at
@sangerinstitute.bsky.social
Tree of Life, to work on the Biodiversity Cell Atlas initiative with @marakat.bsky.social and me.

📅 Apply by January 18
🔗 sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Please share with anyone who might be interested!

🚨🚨🚨

We're looking for a research tech to work on alt splicing, pancreatic islets and diabetes. The goal is to set a high-throughput platform to investigate the role of alternative exons in beta cell biology!

Interested in joining our lab at @melisupf.bsky.social? 👇

www.upf.edu/documents/d/...

Launch of new Canada Impact+ Research Training Awards As announced in Budget 2025 -

Canada is launching a new funding program for PhD students and postdoctoral scientists.

Reach out to me if you are interested in studying gene regulation, RNA splicing and/or cancer immunotherapy using computational and/or experimental approaches.

#PhD #Postdoc

34 projectes de recerca biomèdica amb potencial impacte social reben 26 milions en ajuts de la Fundació ”la Caixa” | MediaHub de la Fundació "la Caixa" La convocatòria d'Investigació en Salut 2025 ha seleccionat 34 projectes de recerca biomèdica que han dotat amb un milió d'euros.

2️⃣ #InvestigadorsICREA seleccionats a la convocatòria @caixaresearch.bsky.social d'Investigació en Salut.

🔹Maria Macias @maciaslab.bsky.social @irbbarcelona.org
🔹Manuel Irimia @mirimiam.bsky.social @upf.edu

Enhorabona per aquest impuls per a la vostra carrera investigadora. 🚀
short.do/iLiUwr

Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback - Nature Ecology & Evolution A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions th...

nature.com/articles/s41559-025-02926-x

📣 Save the date!
On December 12th, The future of ART is now! The 6th symposium Catedra Eugin - @upf.edu will happen at the
@prbb.org

Registration is free - tuit.cat/l7reG
#AssistedReproduction #artificiallntelligence

Several opportunities to join our group as a PhD candidate with bioinformatics or experimental background and interests in #microbiome, #Candida, or #evolution.

👉 IRB call:
www.irbbarcelona.org/en/careers/y...
👉 Inphinit call:
lacaixafoundation.org/en/doctoral-...
👉 EvoMG call
www.evomg-dn.eu

We’re excited to introduce @mirimiam.bsky.social (@crg.eu ), one of our EvoMG-DN PIs!

Explore the project and PhD details on our website → www.evomg-dn.eu

#PhD #DoctoralTraining #ResearchCareers #LifeSciences #BiomedicalResearch #Genomics #EvolutionaryBiology #MSCA #HorizonEurope #EUResearch

1/ 🩸 Diabetes occurs when the beta cells in the pancreas, which produce insulin, don't function or have been destroyed.

With a #Health Research grant ➕ BreakthroughT1D, @mirimiam.bsky.social seeks to improve the beta cells it has created in the lab for use as therapy.

https://tinyurl.com/sdhs5yrp

Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.

Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9

Still looking for our perfect doctoral candidate as part of @evomg-dn.bsky.social - come and join us to work on the evolutionary pressures that shape gene expression and disease in the uterus!

Please RT (or is it RB? not sure how our lingo has changed!)

Hey, thanks to the @evomg-dn.bsky.social you can join the Developmental and Evolutionary Transcriptomics Laboratory led by Manuel Irimia ( @mirimiam.bsky.social ) with Jonàs Juan as PI to develop your PhD exploring the molecular adaptation of pancreatic islets. 🧬🦇

#PhDOffer #AcademicJobs @crg.eu

Meet our EvoMG-DN PI, Jonas Juan-Mateu from @melisupf.bsky.social -Barcelona

Interested in joining the network? Find out more about the PhD programme → www.evomg-dn.eu

#PhD #DoctoralTraining #ResearchCareers #LifeSciences #BiomedicalResearch #Genomics #EvolutionaryBiology #MSCA #HorizonEurope

🚨 15 days left to apply!
Be part of EvoMG-DN and advance your PhD career in evolutionary genomics.
👉 www.evomg-dn.eu

#PhD #DoctoralTraining #ResearchCareers #LifeSciences #BiomedicalResearch #Genomics #EvolutionaryBiology #MSCA #HorizonEurope #EUResearch #ResearchOpportunities #PhDPositions

Dario Valenzano at PRBB

Today we had a great EvoMG Seminar by Dario Valenzano @dvalenzano.bsky.social from FLI, who told us about some of their recent aging work using the fascinating short-lived killifish.

Hosted by @mirimiam.bsky.social

evomedgenomics.com/events/exter...

6 ways evolutionary medicine can transform our health Evolutionary medicine is an emerging interdisciplinary field with huge potential to improve human health and tackle a broad scope of major health challenges.

1. Map evolutionary diversity to hack biomedical innovation
2. Revolutionize cancer therapy
3. Target the development of antimicrobial resistance
4. Address Anthropocene-related diseases
5. Support healthier behaviors
6. Improve pandemic responses
by Barbara Natterson-Horowitz & Dan Blumstein!