Matthew Tegtmeyer

By integrating transcriptomics, we linked altered gene expression of cell adhesion molecules to disrupted mitochondrial morphology. This innovative approach provides new leads for understanding neuropsychiatric disorders. 🧩🔬

@bethcimini.bsky.social
Using NeuroPainting, we uncovered unique morphological signatures tied to the 22q11.2 deletion, a top genetic risk factor for schizophrenia. Key changes were found in mitochondrial structure and ER dynamics, especially in astrocytes. 🧬💡

Combining NeuroPainting with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion Neuropsychiatric conditions pose substantial challenges for therapeutic development due to their complex and poorly understood underlying mechanisms. High-throughput, unbiased phenotypic assays presen...

@drannecarpenter.bsky.social @shantanuxsingh.bsky.social #preprint
We developed NeuroPainting, an advanced morphological profiling tool adapted from Cell Painting, tailored for neural cells. This method captures over 4,000 cellular traits, setting a new standard for neuropsychiatric research. 🧠🔍