IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members @cp-cellreports.bsky.social www.cell.com/cell-reports...
05.03.2026 16:41
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IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members @cp-cellreports.bsky.social www.cell.com/cell-reports...
The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack
Microbiota impact peanut allergy
Saliva & jejunum harbor peanut-degrading bacteria(Rothia) that metabolize immunodominant PN allergens. Mice colonized w/Rothia show ⬇️anaphylaxis & allergic patients w/better PN tolerance have ⬆️abundance of these bacteria
www.cell.com/cell-host-mi...
Delighted to share our new #preprint on #mastcell desensitization on @biorxiv-immuno.bsky.social
We show that #mastcell #desensitization involves #IgE internalization and induces distinct #immunoregulatory #transcriptional program linked to #immune regulation.
www.biorxiv.org/content/10.6...
Mast cell desensitization induces a distinct IgE-dependent transcriptional program associated with immune regulation https://www.biorxiv.org/content/10.64898/2026.02.28.708745v1
Muy agradecidos a El Mundo por divulgar nuestro trabajo en
@cp-cellhostmicrobe.bsky.social donde demostramos que #bacterias orales degradan #alérgenos alimentarios, modulando respuestas #IgE y #anafilaxia.
www.elmundo.es/ciencia-y-sa...
La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa y la Universidad de Canadá: okdiario.com/salud/saliva...
Human oral microbes degrade peanut allergens, thereby reducing IgE recognition, systemic availability, mast cell activation, and anaphylaxis @cp-cellhostmicrobe.bsky.social
www.cell.com/cell-host-mi...
Las bacterias de la saliva pueden ayudar a reducir las reacciones alérgicas al cacahuete: www.agenciasinc.es/Noticias/Las...
The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack
Our pleasure, Salva! :)
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes @cp-immunity.bsky.social
www.cell.com/immunity/ful... @rockefeller.edu
🧵 1/6 Vaccinating allergic patients carries risks: the patient’s IgE recognizes allergen extracts and can trigger severe adverse reactions. To address this, Dr. Roy Patterson (1970s) proposed an innovative approach: modifying the extracts by polymerizing them with glutaraldehyde.
Today at #PreprintHub2, Elisa Sánchez from Universidad Autónoma de Madrid will present the preprint by @alexaweingarden.bsky.social, “Gut microbial composition modulates food-specific CD4+ T cells in food allergy” from the Marc K. Jenkins lab 🥜🤒❌
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social A single-cell atlas of intestinal immune cells across the day-night cycle reveals dynamic populations
www.biorxiv.org/content/10.6...
@jkpfeiff.bsky.social @utswim.bsky.social @lhooperlab.bsky.social
Review @natrevimmunol.nature.com
How crosstalk at the immune synapse shapes T cell and dendritic cell biologys
www.nature.com/articles/s41...
New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/
Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social
🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1
Grateful for the invitation to present at the 3rd Research Day of the METRI²A Group at @idibaps.bsky.social. A pleasure to discuss how #microbial metabolism of allergens impacts #allergicinflammation and #anaphylaxis.
Researchers in #ScienceTranslationalMedicine find a distinct #Bcell and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg #allergy. https://scim.ag/48rPBGS
We enjoyed discussing in @allergy-eaaci.bsky.social the findings by Cembellin-Prieto et al. (@johnshopkinsmmi.bsky.social) published in @natimmunol.nature.com, who identified a regulatory #mechanism mediated by #Bcell-derived #acetylcholine during #influenza #infection.
doi.org/10.1111/all....
“The bad review will come from your list of suggested reviewers”
Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research
go.nature.com/4hriohE
We #run for #science & type 2 #immunity in #Madrid!
#YoCorroPorLaCiencia @csic.es
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
SMI Member Eduardo Villablanca and colleagues review B cells in inflammatory bowel disease at Immunology Letters:
www.sciencedirect.com/science/arti...
#SMIMemberPaper #MucosalImmunology #Immunology
I’m excited to share a perspective that an incredible group of experts in the B cell field worked on over the past 2 years. The thoughtful conversations resulted in what we hope will be a helpful framework moving forward. An open access link is available below:
urldefense.com/v3/__https:/...
Celia & Elisa participated at #SICAM at isciiisalud.bsky.social. Contrats to Elisa for winning the Best Oral Talk Award (sponsored by Inmunotek) on #Microbial #metabolism of food #allergens drives #IgE-mediated #anaphylaxis. A collaboration with the Caminero Lab at @mcmasteruniversity.bsky.social
