Francois Lebreton

Thanks Olaya! Hope all is well for you in Toulouse. Will you be at #ESCMID26 in Munich? Would be great to catch up on Kleb panel plasmids and more.

Cumulative cgMLST provides increased discrimination of nested phylogenetic groups Background Core genome multilocus sequence typing (cgMLST) is a powerful method for bacterial strain genotyping. However, the size of the core genome decreases as the phylogenetic breadth of the targe...

Cumulative cgMLST : Our novel preprint is out @biorxiv doi.org/10.1101/2025...

Implications: We argue that convergent isolates, which emerged globally through the last decade, represent a distinct evolutionary state optimized for transmission rather than systemic invasion. Big thanks to our amazing team and collaborators from all around the globe!

Key findings: Convergence follows preferred, constrained evolutionary paths. The dominant route involves acquiring conjugative IncFIB(Mar)/IncHI1B plasmids with incomplete virulence genes. Iron-scavenging (aerobactin) was the universal trait of convergence — not hypervirulence (Thanks Russo Lab!).

New preprint out! Anjali Sapre, Melissa Martin and co. mapped the evolutionary routes of convergence in K pneumo. Pop analysis of >1,400 global genomes & 7,500 closed plasmids to see how #AMR & virulence genes come together and impact phenotypes. www.researchsquare.com/article/rs-8...

Please visit: www.icarecourse.org
@ICARe_AMR has a great atmosphere and location @LesPensieres , with a unique faculty and a special session on #AMR #genomics with François Lebreton @flebreton.bsky.social and myself – great opportunities for networking and scientific discussions

New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!

Thanks Willem! Any chance you are at #ESCMID2025?