Emily Condiff

New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...

Rio’s bloodiest day: the untold story of Brazil’s most deadly police raid In interviews with community leaders, lawyers, security specialists and bereaved relatives, the Guardian pieces together how an operation targeting a criminal gang left 122 people dead last October

"In more than two dozen interviews with community leaders, lawyers, security specialists and bereaved relatives, the Guardian pieced together the story of the bloodiest day in Rio’s modern history" www.theguardian.com/world/2026/f...

gradient.horse Draw a horse, watch it run!

omg everybody go draw a horse this is what the internet was made for

gradient.horse

Why Seeing Still Matters in Biology - the Node or, Why all biologists needs data visualization Biology probes form and function of Life. Form is easy to grasp: cells under a microscope, subcellular

Why Seeing Still Matters in Biology

@helenajambor.bsky.social addresses why all biologists need data visualisation. Read and discuss this topic on the Node. ⬇️

#DataVis #BioVis

thenode.biologists.com/why-seeing-s...

An excellent Sunday read, thought-provoking as ever: Ruslan Medzhitov on the balance of data and conceptualization. Well worth keeping in mind as we design new projects and interpret results. 📑💡

Bad Bunny “together we are America”

A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams.
www.biorxiv.org/content/10.1...

Homeland Security Spies on Reddit Users Leak show feds tracking anti-ICE Reddit users like "Budget-Chicken-2425"

Homeland Security is monitoring anti-ICE Reddit posts, an intelligence bulletin leaked to me reveals:
www.kenklippenstein.com/p/homeland-s...

Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues Methods for spatially resolved cellular profiling of tissue sections enable in-depth study of inter- and intra-sample heterogeneity but often profile …

In spatial omic, using standard 2D sections undersamples 3D tumors and tissues, always.

We asked how many slides or cores of a TMA are needed to capture the variations in tissue composition in a single 3D tumor?

A lot!

Download here: www.sciencedirect.com/science/arti...

Front page of the paper copy of the Onion for Jan-Feb 2026. Top headlines are “340 Million Americans Killed in Botched Training Exercise” and “US Reaches Trade Deal with Pedotopia”

Advertisement for the U.S. Postal Service showing a picture of a mail delivery truck with the red slogan “You can’t send anthrax in an email”

Opinion section from The Onion with an article titled “Anyone else have those weird dreams where sobbing future generations beg you to change course?” By Sam Altman, CEO of OpenAI

Article in The Onion with the headline “Biologists Confirm Not much Evolution Happened Today”

Got my first paper copy of @theonion.com after receiving a subscription for christmas. It’s brilliant- even the ads. Go subscribe if you haven’t already

Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again.
#Pinks #ProudBlue

Environmentally driven immune imprinting protects against allergy - Nature In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship between environmental antigen exposure and subsequent allergy.

Nature research paper: Environmentally driven immune imprinting protects against allergy

go.nature.com/46lGExb

Everyone vs ICE: On the Ground In Minnesota Podcast Episode · It Could Happen Here · 01/27/2026 · 57m

Everyone vs ICE: On the Ground in Minnesota

Important episode & reporting by @jamesstout.bsky.social & @margaret.bsky.social out now

podcasts.apple.com/us/podcast/i...

www.iheart.com/podcast/1119...

I wrote about my time in Minneapolis last week, about what is involved in creating bottom-up, decentralized networks of care.

margaretkilljoy.substack.com/p/our-neighb...

In vivo detection of immune responses via cytokine activity labeling Cytokine receptor dimerization, induced by the binding of cytokines, can be converted into a genetically traceable fluorescent signal and engineered into reporter mouse lines to visualize processes in...

Tools
'To address this knowledge gap, we developed “cytokine cellular locating platforms” (CyCLoPs), a reporter system that translates cytokine receptor engagement into a genetically traceable signal.'
#Immunology
www.cell.com/cell/abstrac...

I fought in a war zone. ICE isn’t following the rules. - The Boston Globe As an Army veteran, I was trained to show restraint and respect civilians — standards ICE agents now ignore in American neighborhoods.

Great piece by councilor and candidate Matt McLaughlin about the terrible problems with how ICE is prosecuting their mission on US soil. Very much worth a read.

www.bostonglobe.com/2026/01/31/o...

Lab culture 1. Give the work, and each other, 100%. 2. Do work that makes better things possible. 3. Treat the subjects of the work with respect. 4. Treat data with care. 5. Primary research before reviews. 6. Write, speak, and work in specifics. 7. Never stop reading. 8. Chop lettuce once a month. 9. Don't fight your work. 10. Ask for help when you need it! (And be respectful of your teammates' time) 11. Only start what you can finish. 12. Take ownership, give credit. 13. Be honest with the public. 14. Computers don't do your thinking. 15. No money from bastards.

“You can’t judge people for trying to fundraise from a convicted pedophile” yes you can idiot. I’m doing it right now with my big powerful scientist brain. It’s literally part of my lab rules

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma Background Although most studies of anticancer T-cell immunity focus on αβ T cells, γδ T cells are attracting increasing attention due to their involvement in antitumor immune responses in various can...

jitc.bmj.com/content/14/1...

From Kilian Wistuba-Hamprecht lab

A fire hydrant covered in snow

OK. We got a ton of snow and the fire hydrants around town have to be cleared ASAP to keep the city safe. Go out and clear the fire hydrant by your house, take a picture, and then come in for your free ice cream cone and high five. Redeemable this week. Just show the picture to the person working.

One of the best things I’ve read in a while:

The StarTribune live blog is paywall free:
- The man shot by federal agents this morning has died
- Several witnesses have already been transported to the Whipple building.
- ICE attempted to order local police from the scene, but O’Hara refused, sources said.

www.startribune.com/ice-raids-mi...

Councilor seeks snow angels for shoveling; will reward them with free ice cream
www.universalhub.com/2026/council...

#Boston #Roslindale #HydePark #Mattapan #snow

Did you see ICE? Remember ALERTA. Be ready to report Activity, Location, Equipment, Requests for Aid, Time/Date of incident, and their physical Appearances. Vermont Migrant Justice: 802-881-7229 NH Solidarity Network Hotline for Raids 978-219-7586 Mt. Washington Valley Rapid Response Team 603-726-6680 Maine Immigrant's Rights 207-544-9989 Coalition LUCE Immigrant Justice 617-370-5023

If you live in Massachusetts, Maine, New Hampshire, or Vermont save these numbers for the various ICE watch hotlines

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma Background Although most studies of anticancer T-cell immunity focus on αβ T cells, γδ T cells are attracting increasing attention due to their involvement in antitumor immune responses in various can...

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma

#gdTcells @sitcancer.bsky.social

Tiny faux organs could crack the mystery of menstruation Researchers are using organoids to unlock one of the human body’s most mysterious—and miraculous—processes.

'The research is still very much in its infancy. But organoids have already provided insights into how endometrial cells communicate and coordinate, and why menstruation is routine for some people and fraught for others.'
www.technologyreview.com/2023/08/18/1...

'Using live Primary T cells activated on APC-mimetic reconstituted bilayers, in combination with fast super-resolution imaging, an unbiased tracking algorithm, and pharmacological inhibitors, we find that a sizeable fraction of motile clusters translocate not towards cSMAC but away from cSMAC.'

Incredible article which points out that it often collectively costs more to apply for scarce research funding than the funds awarded to the successful proposals.

What an absurd system we've built in the service of efficiency and competition.

www.nature.com/articles/d41...