Ho Quan Yao

Figure Graphical abstract from Klein et al. GPCR, G-protein coupled receptor.

Don't miss our January Literature Watch, "Unraveling and leveraging the molecular structural determinants of chemokine receptor-ligand specificity," by Quan Yao Ho and Fadi Issa
www.amjtransplant.org/article/S160...

Unlike coronary artery disease, VHD is relatively understudied in this context - we hope our work adds meaningful data in this area.

Huge thanks to two amazing med students — Dr. Lye Yan Nerng (now graduated) and Chen Haoyang (soon to graduate) — for making this possible!

2) 1 in 8 ESKD patients develop de novo or progressive VHD after referral for the waitlist
3) Unsurprisingly, both baseline and incident VHD predicted mortality
4) Age, time on dialysis and CKD-MBD factors independently predicted baseline and incident VHD

Burden of Valvular Heart Disease Diagnosed on Protocolised Echocardiography for Waitlist Placement in End‐Stage Kidney Patients This retrospective cohort study investigates the epidemiology, impact on survival, and risk factors for valvular heart disease in a multi-ethnic Asian population referred to the kidney transplant wai...

Pleased to share our latest publication on the burden of valvular heart disease (VHD) in ESKD patients referred to the transplant waitlist. tinyurl.com/4k6jrdu5 #kidneytransplant #nephrology #duke-nus
Key messages are:
1) VHD is highly prevalent in ESKD patients-even in this highly-selective cohort

Medicine Nobel goes to three researchers who identified immune system’s security guards Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease

This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi

Not all antibody tests agree: this study shows big differences between commercial assays for non-HLA antibodies in kidney transplant rejection. Standardization is urgently needed to clarify their role in AMR and graft loss. #TXPforAll #Transplantation tinyurl.com/c6s5mtk7

Oxford University spinout OrganOx to be acquired by Terumo for a An agreement has been reached for the acquisition of OrganOx, a pioneering University of Oxford spinout transforming kidney and liver transplantation, by Terumo Corporation, a global medical

Oxford Uni spinout @Organ_Ox has been acquired by Japan’s Terumo Corp for $1.5B – the largest-ever acquisition for an Oxford spinout. OrganOx’s game-changing organ preservation tech has powered 6,000+ transplants worldwide. Read more: https://tinyurl.com/yvvtz9ax

- Achieving Early Target Trough Levels of Tacrolimus Using CYP3A5-Guided versus Standard Weight-Based Dosing in a Multi-Ethnic Cohort of Kidney Transplant Recipients in Singapore (Abstract# P2.12.6)

- Rise and Fall of Donor-Derived Cell-Free DNA Following Treatment of Antibody-Mediated Rejection in Asian Kidney Transplant Recipients (Abstract# P1.07.249)

Poster presentations
- Real-World Application of dd-cfDNA in Screening for Rejection and Post-Treatment Monitoring in Asian Kidney Transplant Patients (Abstract# P3.07.201)

Rapid fire oral presentation
- National Trends of Sex Disparity over 5 Decades of Living Donor Kidney Transplantation in Singapore (Abstract# RF07.3)

Four abstracts (again!) for the Singapore General Hospital / SingHealth Duke-NUS Transplant Centre kidney transplant programme at #WTC2025! Proud of our transplant unit's achievement (even though I couldn't make it to WTC/ATC again).

A systematic literature review and meta-analysis evaluated modifiable risk factors for the development of BK polyoma virus-associated complications

doi.org/10.1016/j.kint.2025.06.014

#MedSky #NephSky #kidneytransplantation #bkvirus #TxID

Congratulations to Audrey Au Yong @triglab-oxford.bsky.social for winning the Best Presentation Prize for 1st years at the @ndsurgicalsci.bsky.social Students Symposium! Congrats to all the other award winners too!

"Everyone here is smart, distinguish yourself by being kind" - Emily Bernhardt

Meeting Report: The Sixth International Sam Strober... : Transplantation An abstract is unavailable.

Opening our account here with a recap of our publications this year...

This paper reviews the current state of play in the field of tolerance (and of course of favourite Tregs)

Meeting Report: The Sixth International Sam Strober... : Transplantation journals.lww.com/transplantjo...

Another interrim analysis from our #TTV on our vintage/prevalent #kidneytransplant population. Expect final analysis to be available (hopefully) Q4 2025 to Q1 2026

Sharing our experience using the Highway1 from Cellular Highways (which has been acquired by @stemcell.com) for preenrichment before sorting for human #Tregs

So very pleased to attend the #ESOTCongress2025 with 4 posters between @ndsurgicalsci.bsky.social @triglab-oxford.bsky.social and SGH/Duke-NUS. SUPER happy to see Carolyn from Singapore #kidneytransplant

Helen Stark & Quan Yao Ho dive into key takeaways from the 6th International Sam Strober Workshop on Clinical Immune Tolerance. Don’t miss the latest in groundbreaking tolerance research!
🔗 tts.org/podcast2 #Immunology #TXPforAll #Transplantation @ttsorg @TransplantJrnl