Ali Turk

Deltaviruses spread through a viral Trojan Horse Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

#microsky #synbiosky

Transporters matter!

www.nature.com/articles/s41...

The molecular basis of force selectivity by PIEZO2 Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function.
www.nature.com/articles/s41...

High-frequency biparental inheritance of plant mitochondria upon chilling stress and loss of a genome-degrading nuclease - Nature Plants Maternal inheritance of mitochondria breaks down in the cold when a mitochondrial DNA degrading nuclease is defective, resulting in biparental inheritance that can rescue mitochondrial mutations and g...

Mitochondria can indeed be inherited from the father! 🍀
In this new study, we uncovered the molecular mechanisms underlying mitochondrial inheritance in Nicotiana tabacum. @natplants.nature.com

doi.org/10.1038/s414...

@annaryba.bsky.social's paper on the neural underpinnings of intraspecific behavioral variation is now out in @currentbiology.bsky.social

Highly recommend! -> Paper identifies neural substrate for variation in promiscuity among Drosophila melanogaster strains🧪

www.sciencedirect.com/science/arti...

Aspartate availability drives differential engagement of the malate-aspartate shuttle Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...

Designing chemigenetic DNA nanotrap for norepinephrine dynamic imaging in organelles - Nature Chemical Biology Chen et al. developed a chemigenetic DNA nanoprobe enabling rapid and selective mapping of norepinephrine dynamics in organelles and discovered that norepinephrine bursts in the endoplasmic reticulum ...

A chemigenetic DNA nanoprobe enables rapid and selective mapping of norepinephrine dynamics in organelles and is used to show that norepinephrine bursts in the ER trigger neuronal death during traumatic brain injury

www.nature.com/articles/s41...

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA

www.science.org/doi/10.1126/...

co-first with: @andschwarz.bsky.social

with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more

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#MolBio 🧪

CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome - Nature An orthosteric CSN inhibitor gains nanomolar potency via a molecular-glue mechanism, stabilizing a CSN5–N8–inhibitor complex that confers substrate-dependent inhibition despite weak free-enzyme affinity.

Nature research paper: CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome

go.nature.com/4kwdCRy

Sleep-dependent clearance of brain lipids by peripheral blood cells @nature.com @pennmedicine.bsky.social
www.nature.com/articles/s41...

This is so cool!! Amazing work expanding single cell metabolomics to thousands of metabolites and hundreds of thousands of cells! Shame you need a custom built mass cytometer to do this 🥲 but hopefully someone is on this to make it widely accessible!

p53 increases phospholipid headgroup scavenging in senescence - Nature Cell Biology Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and in...

☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social
bit.ly/4asbwO3

On the balance of knowledge - Nature Reviews Immunology Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...

Priority effects inhibit the repeated evolution of phototrophy - npj Complexity npj Complexity - Priority effects inhibit the repeated evolution of phototrophy

New paper out! Here's a puzzle: phototrophy, the ability to use light for energy, is one of life's great innovations. It evolved early and transformed the biosphere. But it evolved 2x. Why not just once, why not more? Our work suggests the answer is priority effects.

www.nature.com/articles/s44...

Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104.bsky.social ! @biozentrum.unibas.ch , @unibas.ch #cellbio #cell #organelles
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...

New undergraduate summer research opportunities in cardiac research and biomedical engineering at the Cornell Meinig School of Biomedical Engineering, sponsored by the American Heart Association. Apply by Feb. 28 at www.cnf.cornell.edu/education/re.... Please share.

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...

My first paper from my undergraduate work is out today :)

Multiple protein structure alignment at scale with FoldMason Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...

Our new paper reveals critical new regulators of stem cell differentiation that control where the right kinds of cells are made in planarians.

In particular, we find Anosmin—a gene responsible for Kallmann Syndrome—as a restrictor of neurogenesis.
www.nature.com/articles/s41...

#basicresearch

Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is know...

Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...

Quantum spin resonance in engineered proteins for multimodal sensing - Nature A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...

Well that's cool Source: Nature
search.app/FLn5P

Hyperpyramidalized alkenes with bond orders near 1.5 as synthetic building blocks - Nature Chemistry Alkenes are essential functional groups in organic chemistry, featuring well-defined geometries and bond orders of 2. In this study, cubene and 1,7-quadricyclene are calculated to possess unusual hype...

The Garg Lab just putting double bonds wherever now…
I mean c’mon we have RULES here!
Now everyone is gonna want olefins everywhere…

(Awesome paper out in @natchem.nature.com)
Really well done all - excellent work

I have some bad news. One, if you need to use ChatGPT for your graduate application letter, you are not ready for graduate school.

Two, no, not "everyone is doing it" and those who don't do it aren't "losing out." ChatGPT is not an advantage.

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Ideal efficacy photoswitching for chromocontrol of TRPC4/5 channel functions in live tissues - Nature Chemical Biology Using chemical photoswitchable reagents to exert purely wavelength-dependent control over biological systems in deep tissue and in vivo requires a concentration-independent design paradigm. Here, such...

A new paper by @thornsesholdlab.bsky.social reports photoswitchable ligands with wavelength-dependent, and concentration-independent, control of TRPC4/5 channels in live tissues

www.nature.com/articles/s41...

A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

So cool - someone finally hacked 'the vault'.
www.science.org/doi/10.1126/...

A new cell type drove human brain complexity
@science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

A dynamic displacement mechanism drives protein import into mitochondria Most mitochondrial proteins are produced in the cytosol and imported through the translocase of the outer mitochondrial membrane (TOM) to reach their final destination. Although this protein entry gat...

📢 New preprint alert!
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
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