Jakob Woessmann

The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩...

🔗 doi.org/10.64898/202...

Antibody-based signal amplification for single-cell proteomics by mass spectrometry Single-cell proteomics by mass spectrometry (scp-MS) detects thousands of proteins per cell, yet low-abundant proteins routinely detected by antibody-based methods are challenging to quantify in the s...

New preprint! 🚀
We introduce AbTags – antibody–peptide fusion proteins that massively amplify signal, enable absolute quantification of binding events, and are read out together with the single-cell proteome by LC–MS.

AbTag platform is patent-pending.
Preprint: www.biorxiv.org/content/10.6...

Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem...

We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Now published in @science.org together with @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social.
www.science.org/doi/10.1126/...
🧵

Check out our newest paper (tinyurl.com/scp-ms) straight from the lab of @erwinschoof.bsky.social. If you are considering to FAIMS or not to FAIMS and whether wide or narrow window DIA is better, you might find some answers you are looking for. #proteomics

Tenure-track Research Group leader position in translational cancer research at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital A group leader position at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital is open for appointment as soon as possible. The position is av

WE ARE RECRUITING: A tenure-track group leader position in translational cancer research is available at the Finsen Laboratory in Copenhagen. Come join an excellent and friendly research environment combining both hospital and university affiliated groups

candidate.hr-manager.net/ApplicationI...

If you are interested: poster WP724

Informed Data-Independent Acquisition Enables Targeted Quantification of Key Regulatory Proteins in Cell Fate Decision at Single-Cell Resolution Cellular differentiation processes are largely orchestrated by variation in transcription factor (TF) abundance. Since these proteins are usually expressed at extremely low levels, studying TF-driven ...

I am excited to share the first project of my PhD on bioRxiv and just in time for #ASMS2025 !
Increasing the sensitivity in single cell proteomics to quantify transcription factors in single hematopoietic stem and progenitor cells by iDIA.
www.biorxiv.org/content/10.1...

The Cell Diversity Lab is well represented at this year's ASMS; please come and talk with Jakob Woessmann and Benjamin Furtwängler to hear all about their latest efforts in improving, and applying single-cell proteomics by MS.

#singlecellproteomics #teammassspec #cellheterogeneity

Come join us for an exciting postdoc spanning multiple disciplines - CPH is a great place, both for living & doing cutting edge research! :)

Postdoc in Biochemistry

A 3-year post-doc position is available in our group at @ucph.bsky.social from June 1st. The project aims at identifying metabolic pathways altered in Parkinson's Disease using proteomic analyses of brain samples (with @erwinschoof.bsky.social).

Deadline: March 9th

employment.ku.dk/faculty/?sho...