Enrica Boda & team

Astrocyte Cafe - Seminars & 2026 Conference Join the international astrocyte research community. Monthly seminars and the 2026 Pamplona Conference.

Registrations and abstract submissions for #AstrocyteCafe2026 are now OPEN!

Abstract submission will close on April 1st!!!
We hope to see many of you on June 3-5 in Pamplona 🤩

Thanks KernelScience for our new website & for helping organize this conference!
👇👇👇👇
astrocytecafe.com#/conference-...

Megan Doty et al discovered that myelin remains for weeks after cortical axons degenerate. We call the sheaths without an axon de-axoned myelin. During the slow, asynchronous, degeneration, microglia don't play a major role in clearing the axon or de-axoned myelin. www.science.org/doi/10.1126/...

Global O-GlcNAcome Identifies O-GlcNAcylated Proteins Regulating Oligodendrocyte Precursor Cells Differentiation https://www.biorxiv.org/content/10.64898/2026.03.02.709210v1

Premyelinating Oligodendrocyte Survival Governs CNS Remyelination https://www.biorxiv.org/content/10.64898/2026.02.23.707571v1

Selective Cortical Myelination Reflects Axon-Driven Progression of the BCAS1-positive Oligodendrocyte Lineage https://www.biorxiv.org/content/10.64898/2026.02.15.705957v1

Longitudinal magnetic resonance imaging and spectroscopy in a mouse model of cuprizone-induced demyelination https://www.biorxiv.org/content/10.64898/2026.02.18.706313v1

Local demyelination rekindles oligodendrocyte precursor dynamics and remyelination in old age https://www.biorxiv.org/content/10.64898/2026.02.15.705983v1

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

I am delighted to see this work published. A big thanks to everyone, particularly the excellent supervision of @lyons-lab.bsky.social, the work of co-first author @juliavdkorput.bsky.social and wonderful collaborators in Amsterdam and Oregon.
www.science.org/doi/10.1126/...

A big thank you to Fondazione Telethon for their continued commitment to research and for supporting projects aimed at making a real difference for people living with rare genetic diseases.

#raredisease #research #Telethon
#oligodendrocyte #myelin

This support means a lot to us, not just as funding, but as trust in the work we’re doing. Building on the results we got in a former Telethon project, we aim now at optimizing an #oligodendroglia cell replacement strategy to sustain #neurodevelopment in a preclinical model of #microcephaly MCPH17

For this project, we will take advantage of the essential collaboration of Marco Cambiaghi (co-PI, Univ of Verona) and Francesco Ferrini (Univ of Turin)

Fondazione Telethon e Regione Lombardia finanziano 27 progetti di ricerca per 7 milioni di euro - Telethon I progetti sono stati selezionati attraverso un rigoroso processo di valutazione affidato a una Commissione medico-scientifica internazionale.

Really happy to share that we’ve been awarded a #Telethon grant

www.fondazionetelethon.it/storie-e-new...

(continues...)

Diverging routes of oligodendrocyte recruitment in adaptive and regenerative myelination https://www.biorxiv.org/content/10.64898/2026.02.04.703508v1

COUNTERING AGE-ASSOCIATED ALTERATIONS IN OLIGODENDROCYTE-DERIVED EXTRACELLULAR MATRIX REJUVENATES COGNITION https://www.biorxiv.org/content/10.64898/2026.02.03.702938v1

(If I'm not wrong...) Not really establish... OPCs stabilize synapses from retinal ganglion cells

ASCL1 and OLIG2 Expression Dynamics Control Glial Cell Fate and Regional Diversity in the Dorsal Forebrain https://www.biorxiv.org/content/10.64898/2026.02.02.703158v1

Wow! So cool!

🧠 Beautiful seminars by Marie-Eve Paquet and Yves De Koninck (Université Laval & CERVO Brain Research Centre, Quebec) today. Great opportunity to hear about novel tools to target, stimulate and record neurons. Thanks to our friend and collaborator Francesco Ferrini, who organized the meeting.

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity CDC42-effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin-dependent scaffolding of myelin. Myelin o...

If you're interested in the factors that enable the regular structure of CNS #myelin sheaths by #oligodendrocytes, check this out. Featuring a #CDC42 - effector proteins - #septin axis. Congrats to 1st author Sophie, and a big thank you to all who contributed

onlinelibrary.wiley.com/doi/10.1002/...

💡New preprint out! 💥

"Transcranial direct current stimulation (tDCS) promotes myelin repair and plasticity in the mouse motor cortex" in now in Biorxiv, thanks to the collaboration between our lab at Neuroscience Institute Cavalieri Ottolenghi and Marco Cambiaghi's group at University of Verona

👏👏 Big congrats to Martino Bonato who just defended his PhD thesis on Particulate Matter effects in #MultipleSclerosis preclinical models! Ad maiora, Martino!👏👏

And thanks🙏🙏 to Georgia Mandolesi, Davide Lecca, and Alessandra Fiorio Pla for serving as PhD committee!!

Thanks to all investigators involved in the study: Federica Marchiotto, Alessandro Pigozzi, Annalisa Buffo, Mario Buffelli, Marco Cambiaghi

For the first time, here we also report that tDCS promotes myelin plasticity in the intact mouse cortex. These structural changes are accompanied by preservation of interhemispheric cortico-cortical functional connectivity upon injury

We found that enhancing neuronal activity via #tDCS coupled with low-intensity physical activity accelerates #remyelination and increases #oligodendroglia survival and maturation in a model of #myelin damage in the mouse motor cortex

💡New preprint out! 💥

"Transcranial direct current stimulation (tDCS) promotes myelin repair and plasticity in the mouse motor cortex" in now in Biorxiv, thanks to the collaboration between our lab at Neuroscience Institute Cavalieri Ottolenghi and Marco Cambiaghi's group at University of Verona

The ApoC2 mimetic peptide D6PV enhances remyelination by stimulating oxidative phosphorylation in oligodendrocytes https://www.biorxiv.org/content/10.64898/2026.01.22.701034v1

Pre-myelinating oligodendrocyte ADGRG1 is required for axon ensheathment and CNS myelin formation https://www.biorxiv.org/content/10.64898/2026.01.26.701898v1

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal...

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

Depletion of Microglia Increases Cortical Oligodendrocyte Density During Remyelination Cuprizone demyelination induces transient reactive states in deep cortical microglia (MG) through early recovery. Depleting MG in recovery increases the number of deep cortical mature/pre-myelina...

Our Paper is out! We studied cortical microglia and regenerating oligodendrocyte (OL) interactions. In short: demyelination induces transiently reactive microglia and depletion of these reactive microglia increase recovering OL number onlinelibrary.wiley.com/doi/10.1002/...

Transcriptional Heterogeneity Reveals a Synaptic Gene Program in Developing and Adult Human Oligodendrocyte Precursor Cells https://www.biorxiv.org/content/10.64898/2026.01.01.697017v1