Brian Wiltgen

Is spatial navigation innate? The grid cell code exists before navigation experience 🧪🧠

Deconstruction of a memory engram 🧪🧠

Nice work from JJ DYN-O-MITE 🧪🧠

Living Human Brain Cells Play DOOM on a CL1 YouTube video by Cortical Labs

Brain cells on a chip learn to play Doom 🤯🧪🧠

youtu.be/yRV8fSw6HaE

Place cells in space 🚀 🧪🧠

Stuff like this blows my mind 🧪🧠

SNOOP DOGG narrating ‘Planet Earth’ is just the best..... #snake #lizard #funnyanimal YouTube video by BBB( biophile's brain booster)

Teaching my class about fear behaviors today and found this gem online 😅 🧪🧠

www.youtube.com/watch?v=jTZG...

Place cells exhibit no local topography 🧪🧠

CA1 is more than just a spatial map with task signals layered on top 🧪🧠

Hi Monica 👋 I am a neuroscientist and would like to be added to the feed 🧠 My lab website: wiltgenlab.sf.ucdavis.edu and google scholar profile: scholar.google.com/citations?us...

Excited to share our study in Neuron led by
@travisgoode.bsky.social, a K99 PDF (interviewing for Faculty) and Sahay lab team with collaborators at BROAD, Hopkins, and UW Seattle, defining a neural circuit that links prior experience with feeding behavior. Open Access: sahaylab.com/publications

How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠

Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉

Was thinking the same thing 🤔

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells shar...

Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!!
🧪🧠Cell www.cell.com/cell/fulltex...

Tolman's Sunburst Maze 80 Years on: A Meta‐Analysis Reveals Poor Replicability and Little Evidence for Shortcutting In 1946, Tolman et al. reported that rats could take a novel shortcut to a goal after training on an indirect route, supporting the Cognitive Map theory. However, a review of subsequent Sunburst maze...

Can humans & animals really use internal maps to take shortcuts?

Tolman famously said yes - based largely on his Sunburst maze.

Our new review & meta-analysis suggests evidence is far weaker than you might think.
🧵👇 doi.org/10.1111/ejn....

@uofgpsychneuro.bsky.social @ejneuroscience.bsky.social

What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

Dean, College of Biological Sciences - Davis job with University of California, Davis | 676649 University of California, Davis Dean, College of Biological Sciences The University of California, Davis (UC Davis) seeks a dynamic, effective, and

Reminder - a great job opportunity at @ucdavis.bsky.social

Dean, College of Biological Sciences jobs.sciencecareers.org/job/676649/d...

Rethinking the centrality of brain areas in understanding functional organization - Nature Neuroscience Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas in neuroscience from the ...

A must-read review. It argues that brain areas are only one of several organizing principles and are not especially central, given their weak correspondence to function. Cytoarchitecture and connectivity are a starting point, not the endpoint.
www.nature.com/articles/s41...
#neuroscience

This new preprint by @katewassum.bsky.social is 🔥
Really solid work. It's a must read

This new ERC study uses an overlapping set of human 🧠 donors as our just dropped locus coeruleus preprint. Availability of data from both regions in the same donor facilitates our current efforts to analyze molecular signaling across the circuit, which is highly vulnerable in Alzheimer's disease.

How distributed is the brain-wide network that is recruited for cognition? - Nature Reviews Neuroscience Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...

Thoughtful review with some good recent historical perspective on the ongoing paradigm shift that is radically changing the way we think about what brain areas do.

www.nature.com/articles/s41...

We are all mosaics: vast genetic diversity found between cells in a single person Technical advances allow researchers to trace the genetic changes that occur over time.

One for the heredity scolds: construct a multi-tissue GRM where people
are differentially related to themselves.

www.nature.com/articles/d41...

So terrible 😢

Congrats Sheena!

Billie Eilish Calls on Billionaires to Support People in Need: 'No Hate, But Give Your Money Away' Billie Eilish donates $11.5 million from 'Hit Me Hard and Soft' tour to charity and calls on billionaires to support people in need during hard times.

I don't see a lot of people talking about this, so I want to highlight something GOOD

Billie Eilish stood in a room full of billionaires and said "you're billionaires... Why?"

She donated 11.5 MILLION DOLLARS to food equity and climate orgs, which Stephen Colbert announced to said billionaires.

Molecular mechanisms mediating engram ensemble retrievability state in mice Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram to…

Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)

www.sciencedirect.com/science/arti...

New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...

I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @science.org, where we recorded neurons in bats flying outdoors on an island.

doi.org/10.1126/sci...

With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others

Very interesting work by the Yin lab! 🤔

Yes. And when you're later in your career, you will never agree to do a talk at 8am 😂