One of the main stories of my postdoc is finally out! It builds on an intuition from my early days in omics data analysis: our signaling pathways are simply too small, underrepresenting cellular complexity after stimulation. Something obvious, yet surprisingly hard to quantify.
Unbelievable, but I am part of this lab for half of its life π΅ It just keeps getting better βΊοΈ
Happy to share new work led by @miraburtscher.bsky.social, together with colleagues from @savitski-lab.bsky.social, @saezlab.bsky.social (shout-out to @martingarridorc.bsky.social), @zimmermannlab.bsky.social and others.
Original post + paper below! π
When I first learned about omics at university, I confidently stopped caring about single proteins. Fast-forward 4 years of a systemβs biology PhD, I now have the most amazing favorite single protein which I canβt stop thinking about. Here is the story of how that happened π
Never thought I'd co-first author a paper that appears on the screens on campus, that makes me very happyπ
www.cell.com/cell/fulltex...
Check out the paper and get amazing summaries from the EMBL communications team and a thread by @chanyeong-kim.bsky.social
Just published: "Planetary microbiome structure and generalist-driven gene flow across disparate habitats" by @podlesny.bsky.social @chanyeong-kim.bsky.social and @jonas-bio.bsky.social www.cell.com/cell/fulltex...
See the quoted post below for a thread on the preprint!
New year, new preprint! π
We are excited to share our recent work on #E3 ligase regulation in #metabolism!
www.biorxiv.org/content/10.6...
#ubiquitin #targetedproteindegradation #chemicalbiology
1/6
Want to learn about the theoretical aspects of proteins/peptides analysis by mass spectrometry?
Then join the #EMBLProteomics course where you will get hands-on experience in sample preparation and perform tandem mass tag labelling.
Apply by 3 March:https://s.embl.org/sdp26-01-bl π¬π»
Finally out! π€© Check out our HT- PELSA for high throughput screeningοΌ
Happy to see our HT-PELSA paper now published in @natsmb.nature.com π Big thanks for the constructive review process! πRead the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information β¬οΈ
How can we find out whatβs really going on inside cells when weβre generating so much complex data?
CORNETO is an open-source tool that uses machine learning to turn tangled omics datasets into clear maps of how genes, proteins, and signalling pathways interact.
www.ebi.ac.uk/about/news/r... π§ͺ
integrated temporally resolved transcriptomic, proteomic, and secretomic profiling of human kidney mesenchymal cells from @savitski-lab.bsky.social @saezlab.bsky.social @miraburtscher.bsky.social identify dynamic changes upon TGF-beta stimulation β‘οΈ www.embopress.org/doi/full/10....
Big congrats to everyone involved - it was a blast! π If you're interested in #multiomics integration or #kidneyfibrosis, check it out! β¬οΈ
Ever wondered which method to use to infer kinase activities from phosphoproteomics data? π»πOur revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com π¬ tinyurl.com/4twuc6z4
Online now - the Spotlight "Accelerating the stride toward functional #glycoproteomics" from @timveth.bsky.social and @nmriley.bsky.social.
#Glycoproteins #Glycoforms #Glycoprofiling #DQGlyco #Glycotime
authors.elsevier.com/a/1l3k53S6Gf...
Want to know how the ligands interact with proteins beyond model cell lines, e.g., in tissues or bacteria? Interested in membrane targets? Check out our High-Throughput PELSA method which allows you do all these cool screenings for dozens of ligands within two hours! www.biorxiv.org/content/10.1...
Excited to share our new paper! If youβre interested in glycoproteomics, be sure to check it out π
Huge kudos to all coauthors, especially the amazing glycoteam: Clement, @miraburtscher.bsky.social, Isabelle, and Misha (@savitski-lab.bsky.social)!
Bacteria can influence how sugars modify proteins in the brain β shown for the first time by EMBL researchers.
In their study, the scientists describe a new method to study glycosylation systematically & quantitatively, leading to new biological insights. π§ͺπ§ π
www.embl.org/news/science...
Excited to see this huge piece of work out π Congrats to everyone involved! If you ever wanted to read a 8in1 paper grab a cup of tea and enjoy π
