Lauri Elsilä's Avatar

Lauri Elsilä

@laelsila

Behavioural pharmacologist Doctoral researcher + University instructor @helsinki.fi Mice • #psychedelics • Addiction • Behaviour Cats • #kungfu • Cooking • Craft beer • #mead https://www.laurielsila.fi

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19.11.2024
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Latest posts by Lauri Elsilä @laelsila

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A neuromodulatory circuit-to-molecular pathway for reformatting aversive memories during recall Tan et al. identify a neuromodulatory circuit-to-molecular pathway in rats that updates aversive memories when they are recalled. Noradrenaline from the locus coeruleus triggers synapse-to-nuclear tra...

Excited to share our new paper:
We uncover a locus coeruleus→amygdala circuit linking β-adrenergic signaling to transcription regulation in defined amygdala cells during memory reconsolidation—+ stress or elevated noradrenergic signaling at recall can strengthen memory.
www.cell.com/neuron/abstr...

03.03.2026 23:34 👍 80 🔁 36 💬 3 📌 3

Ah, no wonder I've felt drawn to associative learning for years now. This explains a lot!

27.02.2026 08:05 👍 1 🔁 0 💬 0 📌 0
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We are excited to share our keynote speakers for the 35th Annual IBNS Meeting in Cape Town, South Africa! Join us June 23-27th!

05.12.2025 03:52 👍 12 🔁 6 💬 0 📌 0

Thread of French and Dutch research institutes slowly unsubscribing from web of science (and thence impact factors).

03.12.2025 06:53 👍 78 🔁 35 💬 2 📌 6
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What makes an incel? An interview study of current and former incels This study explores the way current and former incels discursively construct inceldom and negotiate their relationship to it. The data of six semi-structured, in-depth interviews show the difficult...

My article on how current and former incels negotiate what 'incel' means to them is out. Spoiler: it's complicated.

'Incel' meant very different things to different individuals, but spending time on forums negatively affected all participants' mental well-being.

www.tandfonline.com/doi/full/10....

03.12.2025 10:12 👍 5 🔁 3 💬 0 📌 0
Two posts from Bluesky. The first one shows a figure from a paper published in Nature Scientific Reports full of totally incoherent AI fabricated gibberish words. The other a comment on a recently published paper by eLife discussing the paper and its peer reviews which were published along with the paper.

Two posts from Bluesky. The first one shows a figure from a paper published in Nature Scientific Reports full of totally incoherent AI fabricated gibberish words. The other a comment on a recently published paper by eLife discussing the paper and its peer reviews which were published along with the paper.

Nature Sci Rep publishes incoherent AI slop. eLife publishes a paper which the reviewers didn't agree with, making all the comments and responses public with thoughtful commentary. One of these journals got delisted by Web of Science for quality concerns from not doing peer review. Guess which one?

27.11.2025 13:35 👍 156 🔁 69 💬 4 📌 8

Congrats!

24.11.2025 20:11 👍 1 🔁 0 💬 0 📌 0
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Trainees we want to hear your insights! Have your travel award proposal reviewed and receive feedback to strengthen your application. Submit by 11/7. #IBNSSouthAfrica www.ibnsconnect.org/travel-awards

05.11.2025 14:41 👍 3 🔁 3 💬 0 📌 0

The autumnal oak-in-a-pot certainly looks charming!

02.11.2025 10:31 👍 1 🔁 0 💬 1 📌 0
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Psychedelics muddy fMRI results: Q&A with Adam Bauer and Jonah Padawer-Curry The drugs disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help…

Psychedelics disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/psychedelics...

29.10.2025 18:05 👍 39 🔁 19 💬 1 📌 1
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Postdoctoral Fellowship Opportunity

We are looking for excellent MD Psychiatrist applicants to work & train at the CPCR at Johns Hopkins
@jhpsychedelics.bsky.social, the largest and most comprehensive psychedelic research program in the world.

Email Dr. Sandeep Nayak smn@jhmi.edu

30.10.2025 19:53 👍 8 🔁 5 💬 0 📌 1
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Submit your symposia for the IBNS 35th Annual Meeting in Cape Town, South Africa today! #IBNSSouthAfrica www.ibnsconnect.org/ibns-annual-...

28.10.2025 19:18 👍 3 🔁 2 💬 0 📌 0
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Monty Python understood p-hacking

23.10.2025 08:43 👍 499 🔁 143 💬 5 📌 10
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Interested in the complexity of the brain and the mind? 🧠

Join the School 𝐂𝐨𝐦𝐩𝐥𝐞𝐱𝐢𝐭𝐲 𝐢𝐧 𝐌𝐞𝐧𝐭𝐚𝐥 𝐇𝐞𝐚𝐥𝐭𝐡
📌 Erice, Sicily
📅 26 April–1 May 2026

An #interdisciplinary dialogue on how #mental_states emerge from the #dynamics of 𝐧𝐞𝐮𝐫𝐚𝐥 𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐞𝐬 and 𝐜𝐨𝐧𝐭𝐞𝐱𝐭𝐮𝐚𝐥 𝐟𝐚𝐜𝐭𝐨𝐫𝐬

centromajorana.it/mentalhealth...

23.10.2025 09:57 👍 10 🔁 2 💬 0 📌 1
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Meet the team of EU-SABV!
This is a group of researchers with a special interest of including sex as a biological variable into their work.
For the next 4 years, this team will work to enhance current SABV policy in preclinical research!
#SABV
@costprogramme.bsky.social
@jaricivana.bsky.social

23.10.2025 07:27 👍 7 🔁 6 💬 1 📌 0
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Serial Ketamine Infusions for Depression This randomized clinical trial evaluates outcomes following adjunctive ketamine infusions vs midazolam for depression.

New 6-month depression RCT in n=65, serial Ketamine infusions as adjunctive care vs active placebo midazolam.

Ketamine did not outperform primary nor any of the secondary efficacy, cognitive, economic, or quality-of-life outcomes.

🧪 #psychiary #PsychSciSky

jamanetwork.com/journals/jam...

23.10.2025 08:11 👍 62 🔁 13 💬 3 📌 3
View of Cape Town from Table Mountain

View of Cape Town from Table Mountain

Do you have a behavioral neuroscience topic that you want to bring everyone to the table to discuss? Come to #IBNSSouthAfrica submit your symposia by Oct 28th www.ibnsconnect.org/ibns-annual-...

22.10.2025 13:03 👍 5 🔁 5 💬 0 📌 0
Two drawn mice, one focusing on a slot machine and the other staring to the opposite direction with psilocybe mushrooms and Claciceps purpura infected cereal attached to its head, with a wine glass and two bubble-like decorative elements in the background.

Two drawn mice, one focusing on a slot machine and the other staring to the opposite direction with psilocybe mushrooms and Claciceps purpura infected cereal attached to its head, with a wine glass and two bubble-like decorative elements in the background.

I am (finally!) defending my doctoral thesis in late September with a title 'Addiction-related behavioural effects of lysergic acid diethylamide in mice – Exploring the intersection of #psychedelic drugs, #addiction, and #therapeutics'.

27.08.2025 12:14 👍 4 🔁 1 💬 0 📌 0
Two drawn mice, one focusing on a slot machine and the other staring to the opposite direction with psilocybe mushrooms and Claciceps purpura infected cereal attached to its head, with a wine glass and two bubble-like decorative elements in the background.

Two drawn mice, one focusing on a slot machine and the other staring to the opposite direction with psilocybe mushrooms and Claciceps purpura infected cereal attached to its head, with a wine glass and two bubble-like decorative elements in the background.

I am (finally!) defending my doctoral thesis in late September with a title 'Addiction-related behavioural effects of lysergic acid diethylamide in mice – Exploring the intersection of #psychedelic drugs, #addiction, and #therapeutics'.

27.08.2025 12:14 👍 4 🔁 1 💬 0 📌 0
Several glass bottles, both clear and dark brown, on a kitchen counter filled with mead.

Several glass bottles, both clear and dark brown, on a kitchen counter filled with mead.

A #mead update no 3 - bottling

Didn't end up cold crashing the cyser as it cleared out nicely on its own. I've been lazy, so I got to bottling only now. The taste has a very nice apple flavour to it, no sharpness of alcohol. Added honey at the end, aiming mid-sweet.

Waiting to start a next one!

10.08.2025 17:09 👍 0 🔁 0 💬 0 📌 0
A lovely graphic from The Allied Genetics Conference 2020 depicting the many model organisms that contribute to our understanding of science.

https://genetics-gsa.org/drosophila-2025/professional-development/careers-at-tagc/

A lovely graphic from The Allied Genetics Conference 2020 depicting the many model organisms that contribute to our understanding of science. https://genetics-gsa.org/drosophila-2025/professional-development/careers-at-tagc/

CONCLUSIONS:

To promote the best science being done, we need to look at the incentives of science publishing and funding. Long-term funding produces better science. Short-term and topical agendas encourages irreproducibility.

Funding model organisms generates science we can build on! 🪰🪱🦠🐠🐁🐸

6/6 🧵

10.07.2025 08:21 👍 52 🔁 20 💬 3 📌 0
Lauri smiling, standing on a hill top overseeing the town of Tromsø in late evening sun.

Lauri smiling, standing on a hill top overseeing the town of Tromsø in late evening sun.

Lauri presenting his scientific poster for two poster visitors in the venue hallway.

Lauri presenting his scientific poster for two poster visitors in the venue hallway.

A summery scenery of a fjord between two mountains basking in the midnight sun.

A summery scenery of a fjord between two mountains basking in the midnight sun.

Had a blast in #ibns2025 @ibnsconnect.bsky.social in Tromsø last week.

Nice people, interesting behavioural science, beautiful scenery, and the northernmost place I've ever visited (and thus experienced the most intense midnight sun, too).

Thanks @cost-teatime.bsky.social for the travel support!

02.07.2025 07:41 👍 3 🔁 0 💬 0 📌 0

It was a very nice meeting. Thanks for the great work!

29.06.2025 16:29 👍 1 🔁 0 💬 0 📌 0
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The IBNS meeting in Tromsø has come to an end. Thank you all for making it a memorable gathering, both scientifically and socially! Hopefully I see you all in Cape Town next year! @ibnsconnect.bsky.social #IBNS2025 #Tromsø #neuroskyence

29.06.2025 13:03 👍 14 🔁 2 💬 1 📌 0

I'm wondering whether the effects really even are that high.

26.06.2025 09:50 👍 0 🔁 0 💬 1 📌 0
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Examining the biological causes of eating disorders to inform treatment strategies Nature Reviews Neuroscience - Recent years have seen a growth in our understanding of the biological drivers of eating disorders and their interactions with environmental and psychosocial factors....

Writing this was like any other act of love - awkward at the start, frustrating at times, but something to be proud of. Very grateful to Dr Kristi Griffiths for agreeing to take on this challenge with me for @natrevneuro.nature.com
www.nature.com/articles/s41...

21.06.2025 03:32 👍 23 🔁 10 💬 2 📌 0
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Sometimes, even quite often, people encounter ‘entities’ on psychedelics, which may give them messages, heal them or sometimes seem to threaten them or cause them harm.
1/

17.06.2025 06:48 👍 4 🔁 1 💬 1 📌 1

Looking forward to this!

17.06.2025 13:37 👍 0 🔁 0 💬 0 📌 0
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Printing my poster ready for @ibnsconnect.bsky.social meeting in Tromsø.

I'll present some preliminary data exploring automated homecages as a method to study voluntary ethanol intake-caused circadian disruptions in mice (and thus travelling with generous support from @cost-teatime.bsky.social!)

17.06.2025 11:29 👍 1 🔁 0 💬 0 📌 0
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At the Bratislava Training School, @nunohfranco.bsky.social will teach key principles of #experimentaldesign—such as randomization, blinding, sample size, and bias control—to help ensure that #animalresearch is reliable, #reproducible, and aligned with the #3Rs.

@costprogramme.bsky.social #training

08.06.2025 17:43 👍 6 🔁 2 💬 0 📌 0