@aesposito1975
#Physicist and cancer #biologist studying how molecular networks encode cell decisions and how mutations hijack cells, leading to #cancer. Centre for Genome Engineering and Maintenance Brunel University of London
I am honoured to be appointed as new Director for @cengem.bsky.social. With massive thanks for Prof Jo Bridger with whom I worked as deputy over the past few years, CHMLS senior leadership for entrusting me with CenGEM and my amazing colleagues for their support.
We are excited to announce HILIGHT 2026: FLIM & Photonics, a free two day technical meeting at Brunel University London on 4thβ5th March 2026.
The programme will include talks from leading experts, posters, flash talks, and dedicated industry exhibition.
Register here: shorturl.at/AwEOv
π FLIM Advent Calendar π
This December weβre revealing speakers for HILIGHT 2026: FLIM & Photonics
Day 1: Prof Ruslan Dmitriev on using FLIM to track nanoplastics in organoids.
Free Event: lnkd.in/eGUXXzNe
LinkedIn Event page: lnkd.in/eBTRJRhq
HILIGHT website Event page : lnkd.in/ewRw4G4j
π FLIM Advent Calendar π
Hereβs the next speaker in our HILIGHT 2026: FLIM & Photonics
Day 3: Dr Conor Treacy @c-trass.bsky.social on multiphoton FLIM and DNA signatures in Pancreatic Cancer Spheroids .
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 8: Dr Sylvain Boust, from III-V Lab, on versatile laser diode for 2ph FLIM at 8 Mpx/s in HILIGHT project.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 9: Prof Gail Mcconnell @gailmcconnell.bsky.social on Multiphoton mesoscale imaging with the Mesolens.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 4: Professor Edoardo Charbon on Picosecond Image Sensors: From FLIM to Quantum Imaging.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
exciting developments for fast FLIM... I have great expectations for 2026 :)
π FLIM Advent Calendar π
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 5: Dr Falk Schneider @faldalf.bsky.social on Navigating Cross-Excitation Challenges in Multiplexed NADH FLIM.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 7: Dr Gunnar Blume on short-pulse semiconductor lasers for fluorescence lifetime imaging and spectroscopy at FBH.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π
The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up.
Day 6: Dr Sara Pellegrini on Pixels for FLIM: SPADs in monolithic and 3D stacked technology.
Free Event: lnkd.in/eGUXXzNe
LinkedIn: lnkd.in/eBTRJRhq
HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π
Hereβs the next speaker in our HILIGHT 2026: FLIM & Photonics
Day 2: Prof Marina Kuimova on measuring cellular viscosity with molecular rotors and FLIM.
Free Event: lnkd.in/eGUXXzNe
LinkedIn Event page: lnkd.in/eBTRJRhq
HILIGHT website Event page : lnkd.in/ewRw4G4j
If you want to know why all biological models are wrong, you will be interested in our latest virtual debate.
open.spotify.com/episode/6Usp...
#biology #model #science
When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph
rudolphlab.com/blog/on-narr...
The audio overview of our latest paper is now available on Spotify: open.spotify.com/episode/6ej9...
#KRAS #metabolism
I'll show a couple of other examples in the next few days
I use #NotebookLM quite a bit for work. Useful for converting your content (in this case, our latest paper) into different formats. Here a #mindmap of "FOXO1 links #KRAS G12D and G12V alleles to glutamine and nitrogen #metabolism in #colorectalcancer" doi.org/10.1038/s443...
www.embopress.org/doi/full/10....
Congratulations to Dilem Shakir, Michael Batie, Chun-Sui Kwok, Niall Kenneth and @srochaliv.bsky.social on their their lovely study describing NF-ΞΊBβs central role in the hypoxia response - just out in EMBO Reports. A pleasure to collaborate with Team Rocha!!π πΎ π
Raw RNA sequencing data www.ncbi.nlm.nih.gov/geo/query/ac...
Raw LC-MS data
doi.org/10.21228/M8N...
I hope you will find it as interesting. This is the first paper of a series of KRAS-related work. Next, we will focus more on signalling, single-cell phenotypes, cell-to-cell communication, and we will also revisit metabolism.
More thanks and details www.linkedin.com/feed/update/...
Are you interested in oncogenic #KRAS and #metabolism? Our latest study reveals how specific KRAS G12D and G12V alleles rewire #glutamine and #nitrogen metabolism in #colorectalcancer through a #FOXO1-dependent pathway.
www.embopress.org/doi/full/10....
Thank you so much for your support! It was great to have you on board
www.embopress.org/doi/full/10....
Congratulations to Suzan Ber and @aesposito1975.bsky.social on their lovely study of KRAS alleles on glutamine and nitrogen metablism and signalling - just out in EMBO Reports. Such a pleasure to collaborate on this fascinating project! π
Another key milestone in the #HILIGHTProject development roadmap π
Our first multi-section 905 nm laser purpose-built for #2phFLIM is fabricated! π¬
π§ͺ Next: characterisation at #III-VLab.
@csem.ch , #BrunelUniversityLondon, @aesposito1975.bsky.social, #FBK, #VivaScope
hilighthorizon.eu/blog/
Happy new academic year for all our students and colleagues at Brunel.
#bruneluniversity #success @cengem.bsky.social
New Microscopills episode!
We explore optogenetics: the science of using light to control living cells. From mapping brain circuits to controlling biochemical reactions, a 5-minute guide to optogenetics.
open.spotify.com/episode/4e7j...
#Microscopills #Optogenetics #SciencePodcast
Amazing news! Looking forward to this new sensor. FBK is doing an amazing job as always!!!
I might have spoken too fast. For some tasks amazing, for others is a pain. The worst thing is that OpenAI has removed the previous models so we have no choice.... let's see how things will develop over the next few days
#GPT5 is out. Superslow but the level of detail that gives is impressive at least as judged from initial accidental (I had not noticed it was rolled out as I was working on custom GPTs) use!
Great opportunity for a bioinformatician to join an amazing lab in #Amsterdam #JobOpportunity #bioinformatics #gastruloids
www.sanquin.org/working-at/v...
