Vojtech Spiwok

Ancient amino acid sets enable stable protein folds Early proteins likely arose from a chemically limited set of amino acids available through prebiotic chemistry, raising a central question in molecular evolution: could such primitive compositions yie...

Can proteins fold and function with half of the amino acid alphabet?
Using only 10 residues, we designed stable, mutation-resilient structures—no aromatics or basics involved.
A minimalist foundation for ancient biology and synthetic design. tinyurl.com/37t8br4v
#ProteinDesign #OriginsOfLife

22nd Structural Biology Club online on 26th November 2025, 1pm CE: Structures in solution: BioSAXS at BM29 ESRF
by Petra Pernot & Cryo-EM data processing in CCP-EM Doppio
by Colin M. Palmer cssb.structbio.org/22nd-structu...

Homology modeling

Gruezi!

Protein Production Hands-On Workshop Dates: December 2 – 4, 2025 Venue: BIOCEV, Vestec Registration Deadline: October 31, 2025 Cost: Free of charge (accommodation not included) Registration Link: forms.biocev.org/index.php/14... Workshop Page: www.ibt.cas.cz/en/core-faci...

Thanks!

Protein design by parallel tempering in the sequence space YouTube video by Vojtech Spiwok

youtu.be/4n4awaRnEOY

Protein design by parallel tempering in the sequence space YouTube video by Vojtech Spiwok

youtu.be/4n4awaRnEOY

Our first protein design paper out in Protein Science
onlinelibrary.wiley.com/doi/10.1002/...

Pranam Chatterjee @pranam.bsky.social and his first AI-generated baby #CecamLLMLugano

#CecamLLMLugano

Traveling to "Generative AI and large language models for protein modeling across sequence-structure-function scales : From predicting protein dynamics to programmable biology and drug design" in Lugano #CecamAILugano @cecamevents.bsky.social

Max Bonomi @bonomimax.bsky.social on IDP modeling by AI @cecamevents.bsky.social #CecamLLMLugano

Prof. Michele Vendruscolo
Dr. Zsuzsanna Dosztányi
ML4NGP Connect series, organized as part of the ongoing activities of the ELIXIR 3D-BioInfo Community and in collaboration with ISCB and 3DSIG.
📢 Date & Time: 30 September 2025 | 17:00-18:00 CEST
Online elixir-europe.org/events/unstr...

Happy birthday ČSBMB #CSBMB2025

Hana Cahová ( @iocbprague.bsky.social ) awarded a medal by CSBMB #CSBMB2025

#csbmb2025

Followed by awards

Kickoff of XXVIII-th congress of the Czech Society for Biochemistry and Molecular Biology ( @febspress.bsky.social member )

🧀

Instruct Director Harald Schwalbe will be in Denmark for the SBiNLab’s 25th anniversary!

www1.bio.ku.dk/english/rese... @schwalbe-lab.bsky.social

Researchers in Denmark can receive access to Instruct technologies and instrumentation here - instruct-eric.org/submit-propo...

Many thanks to @pluskal-lab.org @iocbprague.bsky.social @elixircz.bsky.social for two days of excellent talks at #PragueBioML !

And now something completely different - nanopores! by @scimartin.bsky.social @ethz.ch #PragueBioML @elixircz.bsky.social

Erik Andris @iocbprague.bsky.social on graph NNs #PragueBioML @elixircz.bsky.social

"Second talk" by Anton Bushuiev ( @iocbprague.bsky.social @pluskal-lab.org @josef-sivic.bsky.social ) on protein language models #PragueBioML @elixircz.bsky.social

Intrinsically disordered proteins by @tothpetroczylab.bsky.social #PragueBioML @elixircz.bsky.social

In 2024, IT4Innovations supported thousands of users and hundreds of research projects.

Behind every achievement stand people – our colleagues, partners, and supporters – thank you for making it possible.

🇬🇧 www.it4i.cz/cs/file/e5d7...

#eINFRAcz

Petr Kouba on protein flexibility #PragueBioML @elixircz.bsky.social

Joan Planas-Iglesias on protein aggregation #PragueBioML @elixircz.bsky.social

Stanislav Mazurenko on evolution and protein design #PragueBioML @elixircz.bsky.social