Raju Kumar

I will be presenting my work as a poster at the #FOG2026
You can find the abstract here:
festivalofgenomics.com/london/poste...
I would be very happy to chat about the work, exchange ideas, or simply connect. Please feel free to stop by or reach out. #MASLD #MASH #TCELL

Cellular senescence in normal physiology Long associated with aging, senescent cells can promote health and have physiological roles

Long associated with aging, senescent cells can promote health and have physiological roles | Science www.science.org/doi/10.1126/...

Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease - Nature Immunology Here the authors show that persistent antigen stimulation drives the generation of CD8+ tissue-resident exhausted T cells with distinct developmental origins, function and therapeutic responsiveness w...

Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease www.nature.com/articles/s41...

A convenient single-cell assay for the newly synthesized transcriptome reveals FLI1 regulon downregulation during T cell activation Lyu et al. present a convenient and accessible method for profiling of both regular and newly synthesized transcriptomes in single cells. Using this approach, they characterize the temporal dynamics o...

NOTE-seq simultaneously profiles regular and newly synthesized transcripts in single cells www.cell.com/cell-reports...

Hepatic adaptation to chronic metabolic stress primes tumorigenesis Environmental stresses, such as a high-fat diet, disrupt liver cell balance by promoting pro-survival, developmental, and regenerative programs while impairing key tissue functions. These stress respo...

High-fat diet (HFD) reduces hepatocyte differentiation and makes liver cells more likely to become cancerous #MASLD #MASH www.cell.com/cell/fulltex...

Restoring youth to old immune cells: mRNA therapy turns back the clock Testing in mice suggests that rejuvenating T cells could make vaccines and some cancer therapies more effective.

T-cell ageing is not a fixed process — it is something that is modifiable www.nature.com/articles/d41...

Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses Nature Metabolism - Dietary restriction promotes the expansion of effector T cells via ketone bodies, which enhances anti-tumour immunity and synergizes with immunotherapy in mice.

Dietary restriction enhances CD8+ T cell metabolic fitness via ketone body metabolism
rdcu.be/eVbQN

Persistent glycolysis defines pathological foreign body–associated inflammation to polymeric implants Persistent glycolytic dependence underlies chronic inflammation and deleterious fibrosis associated with implant complications.

Glycolytic macrophages are associated with proinflammatory functions in proximity with activated fibroblasts| Science Advances www.science.org/doi/10.1126/...

🚀 New preprint!
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...

Real-World Evidence (#RWE) is crucial for understanding the full spectrum of #MASLD.

Our new review in @thelancet.com Reg. Heal. Eur. explores how RWE complements RCTs, aids in drug repurposing, and how #AI is improving patient phenotyping.

👇 Read the full paper: www.thelancet.com/journals/lan...

Presenting research poster

Had a great time at the Cambridge Immunology Forum! www.immunology.cam.ac.uk/events/cambr... Loved the talks on T cells and was really happy to share my work. Big thanks to my supervisor, collaborators, lab members & the organisers - honoured to get the Best Poster Prize!

How TCR clonality profiles, distribution in T cell subsets, and bioinformatic screening against continuously improving TCR databases can guide the selection of TCRs for therapeutic application
doi.org/10.3390/cell...

Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity Memory CD8+ T cells have differential cytotoxic capacities across human tissues.

Human memory CD8+ T cell cytotoxicity is intricately regulated by environmental cues reflecting tissue location and antigen specificity
www.science.org/doi/10.1126/...

Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling How hepatocyte lobular organization affects insulin signaling is a question with potential therapeutic significance. He et al. generate mouse models with impairment of insulin signaling specifically i...

Insulin exerts distinct regulatory effects on glucose metabolism in periportal and pericentral hepatocytes: Cell Metabolism www.cell.com/cell-metabol...

Ageing is linked to inflammation — but only in the industrialized world Inflammation, thought to be a driver of age-related disease, does not worsen with age in some Indigenous communities.

Environmental, dietary, and lifestyle factors may hold the key to understand #Inflammaging
www.nature.com/articles/d41...

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors Cd69 mRNA levels distinguish potent and dysfunctional activation among CD69+ CD8 T cells in tumors.

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors | Science Immunology www.science.org/doi/10.1126/...

Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate @natimmunol.nature.com
www.nature.com/articles/s41...

Hello everyone! I am excited to share my blog post on a topic close to my research and history: the liver.

🧬 From Prometheus to P450: Why the Liver Deserves Our Attention 🧪

Read the full post: tumorscholar.github.io/blog/liver.h...
If you have ever underestimated the liver, this post is for you.

Protein Synthesis and Metabolism in T Cells | Annual Reviews - www.annualreviews.org/content/jour...

Tissue-resident memory T cells have high levels of mRNA of proinflammatory cytokines but produce the proteins only upon stimulation. 🧪⑂
The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2

Hey folks! 👋🏽⁣
I’ve just launched my blog, where I'll be sharing thoughts from the bench and the bioinformatics terminal -⁣
Starting with my first post:⁣
𝐏𝐨𝐬𝐭𝐝𝐨𝐜, 𝐏𝐢𝐩𝐞𝐭𝐭𝐞𝐬, 𝐚𝐧𝐝 𝐏𝐚𝐠𝐞𝐬: 𝐀 𝐍𝐞𝐰 𝐂𝐡𝐚𝐩𝐭𝐞𝐫 𝐁𝐞𝐠𝐢𝐧𝐬⁣
⁣⁣I’d love for you to explore it and share your impressions!⁣
#Immunology #SingleCell