José Costa Pereira

🔬Excited to share our new review: “The Power of Movement: How Exercise Influences Chemotherapy-Induced Peripheral Neuropathy” just published in Biomedicines!

Exercise as medicine for CIPN? Maybe… 🏋🏽

Full read here: www.mdpi.com/2227-9059/13...

Global coordination of brain activity by the breathing cycle - Nature Reviews Neuroscience Synchrony between neuronal activity and the respiratory cycle has been observed in numerous brain regions and across many species. Tort et al. discuss the mechanisms by which brain activity is modulat...

Breathing isn’t just for life—it’s a brain pacemaker!

This excellent review reveals how each breath sends sensory waves that globally synchronize neural networks (with implications for "functional connectivity")

Must‑read 👉 doi.org/10.1038/s415...
www.nature.com/articles/s41...

A pontine center in descending pain control The pain experience is modulated by descending pathways. Using an intersectional strategy, Li et al. map anatomical and molecular-spatial features of nociceptive descending pathways. Their findings un...

Pain-related input from the ventrolateral periaqueductal gray recruits BarCrh, reduces ascending nociceptive transmission.activates spinal dynorphin neurons to mediate analgesia.. a pontine inhibitory descending pathway powerfully controls nocifensive sensory input to the brain.
tinyurl.com/bdht38hy

Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eatin...

New @science.org
Hedonic eating (eating for pleasure, not need) is mediated by dopamine neurons (in the brain ventral segmental area, VTA) and they are antagonized by GLP-1 drugs, such as semaglutide, leading to weight loss
www.science.org/doi/10.1126/...

Can we use brain scans to identify biologically distinct "autisms"? And If so, how?

In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions!

Find out more here 👇👇
www.biorxiv.org/content/10.1...

Thread below 🧵 1/n

A 5 de janeiro de 1932 nascia Umberto Eco

👉 Recorda este artigo sobre o escritor, filósofo e linguista italiano:https://comunidadeculturaearte.com/umberto-eco-o-academico-sabio/

"Odeio festas de Ano novo. Estão todos desesperados para se divertirem. Tentam comemorar de algum modo patético. Comemorar o quê? Um passo mais perto da sepultura?"

Filme "Whatever Works" (2009)

Para o jantar de família👇

Isto devia arrepiar as pessoas!

“Ser cientista é uma função de quão intensa e profunda é a sua curiosidade sobre o mundo que o rodeia”

Early-life adversity mediates a thalamo-amgydalar circuit dysfunction underlying chronic pain and anxiety https://www.biorxiv.org/content/10.1101/2024.12.13.628438v1

Nunca esquecer!

"É preciso criar histórias em que o vencedor não é o mais poderoso.”

When you switch the order of the co-firsts

BOOM! Re-upping our Pain Research Starter Pack since so many people have joined this glorious place in the past week. If you are not on the list and want to be added, let me know and I will add you... I have been doing my best to keep this updated.
#painresearch
go.bsky.app/KboKNhg

Sex-dependent effects of the targeted nerve growth factor... : PAIN inflammation-induced pain-related behaviors and bone loss. The hNGF-R100E mutation did not alter the nerve fiber density in the sciatic nerve, ankle joint synovium, and skin of naïve mice. Withdrawal ...

Cool new paper from Camilla Svensson’s team and a reminder to not give up understanding NGF signsling for pain treatment! journals.lww.com/pain/fulltex...

Let's unleash the axonal growth cones for this #Fluorescencefriday ! #neuroscience #Liveimaging #microscopy #Axonguidance

A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing - Nature Communications Gastric pain has limited treatment options and the nociceptive ascending pathway remains largely unclear. Here, the authors identify a glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuit that provides...

Two BOOM!s in one day: www.nature.com/articles/s41... This flies totally in the face of what I think I know about visceral pain, but when evidence challenges your preconceived notions, maybe it is time to consider changing my gastric pain view.

My students convincing me to use google docs instead of word

The FlyWire connectome: neuronal wiring diagram of a complete fly brain Artificial intelligence and human expertise meet to generate a map of all the connections in the fly brain. The resource is already being used by experimentalists and theoreticians to further our unde...

Hard to overstate how pleased I am that the FlyWire consortium converted our FAFB ("Full Adult Fly Brain") EM volume into a connectome, and that the resulting science has been (and will be) so impactful. Thanks to everyone involved. #neuroscience www.nature.com/immersive/d4...