Natacha Comandante-Lou

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...

Interested in #oligodendrocyte metabolism and/or #multiplesclerosis? Our paper is now at Biorxiv! We show that oligos express MCT2, the high affinity monocarboxylate transporter, well known for supplying neurons with astrocyte-derived lactate (astro-neuron lactate shuttle)👇

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum: Neuron www.cell.com/neuron/fullt...

Microscopy photo showing brain atrophy with Alzheimer

How does a brain with #Alzheimer look in the microscope? Neurons are dying, and I literally see holes in the tissue, like below. You can see microglia (🟡), brain immune cells, accumulating where the tissue disappears (hippocampus & entorhinal cortex). Additional markers: Astrocyte(🟣), pTau(🔵). 🧠🔬

Science is an investment that pays enormous dividends. So if you’re business-minded, it’s an offer you can’t refuse!
Here's my full speech from the Stand Up For Science rally in DC today: www.youtube.com/watch?v=eemj...

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature Medicine Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease @naturemedicine.bsky.social
www.nature.com/articles/s41...

I can’t wait to stand up for science on Friday! Join us in the DC rally or another rally in virtually any other state!

🚀 Excited to share our latest work uncovering the cell-cell signals driving an #astrocyte state linked to cognitive decline in #Alzheimer’s 🧠✨ Huge thanks to my amazing collaborators Aiqun Li, Bin Zhang, Roland Friedel, @typlab.bsky.social, David Bennett!
#SingleCell #SpatialTranscriptomics #Glia

PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease https://www.biorxiv.org/content/10.1101/2025.02.24.639868v1