Kevin A. Scott

thank you!

A proteome-wide dependency map of protein interaction motifs Nature Structural & Molecular Biology, Published online: 06 March 2026; doi:10.1038/s41594-026-01762-2Ambjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicted SLiMs required for normal cell proliferation.

ICYMI: New online: A proteome-wide dependency map of protein interaction motifs

woooooo we got the cover! fun article to write, check it out.

📢Our latest issue is now online!

Check out the review behind the cover by @sculpturatus.bsky.social & co. at @uarizona.bsky.social looking at the history, synthesis and medicinal use of cantharidin, LB-100, and their analogs #medchem

pubs.rsc.org/en/content/a...

That's a good point. Vincent do you have a good paper that describes these statistical powers?

This often plays out in phase one though. Phase III will be the real test.

Do you mean toxicity?

“AI” means a hundred different things. In drug discovery, it already works for ADME, PK/PD, and molecule optimization — and that’s real progress. But most failures come from target biology, not chemistry. To bend clinical success, AI must move from optimization to causality.

cattle dog (brattle)

AI Drug Watch update: AI-designed small molecules in the clinic are heavily concentrated in oncology, targeting novel mechanisms (USP1, MAT2A, ENPP1, CDK7, A2A, LSD1, NAMPT). Most are Phase I. The real test? Durability in Phase II+. Let’s see what breaks through.

happy friday

yea it's true. but fun to noodle around a bit. and useful when i have something specific in mind.

it definitely can eat up time but i made this one in five minutes. took me
30 minutes to learn.

i like seeing them in my feed even if i don't engage. i would also just love to see the answers posted. maybe lazy on my part but i like to see that stuff.

i don't understand the question

You can create images like this in a couple minutes using 100% free software. Check out tutorials by @bradyajohnston.bsky.social

PyMol + Blender is cool. Learned this from @bradyajohnston.bsky.social

wow this is super cool. congrats team

disodium glutamate

FDA Approval Watch: Neurodegeneration is getting hot. Small-molecule programs targeting sigma receptors, LRRK2, brain cortisol, ISR stress pathways, and RNA splicing are advancing across Alzheimer’s, Parkinson’s, ALS, and rare ataxias — pushing beyond symptomatic care toward disease modification.

FDA approved ADQUEY (difamilast) for atopic dermatitis. A topical PDE4 inhibitor that reduces inflammatory signaling, offering a non-steroidal option for patients ≥2 years old. Targeted, mechanism-based small-molecule therapies keep advancing.

excellent photo

this is impressive actually

430 picometer what??

FDA Approval of the Month – January
Copper histidinate is now the first FDA-approved treatment for Menkes disease. A major milestone for a devastating X-linked disorder, showing how early, biology-driven intervention can meaningfully improve outcomes for patients and families.

tell me more about MN getting rid of ice cream

excuse me do you have a moment to talk about ball

The Role of Natural Product Chemistry in Drug Discovery: Two Decades of Progress and Perspectives Natural products (NPs) have long played a pivotal role in medicine, serving as both lead compounds and approved drugs in diverse therapeutic areas. Inspired by the 2004 review “The Role of Natural Pro...

as more and more synthetic drugs resemble natural products in their properties, this is a timely overview of natural products in the last 20 years of medicine.

pubs.acs.org/doi/10.1021/...

Investigating the bioorthogonality of isocyanides Isocyanides have been applied in bioorthogonal reactions as triggers for uncaging reactions. However, emerging evidence suggests that they may label proteins covalently. We synthesised a fluorophore-conjugated isocyanide and analysed its protein reactivity. Our results suggest that isocyanides cannot be considered

Let's start the year off right with an exciting paper post!

In this @chemcomm.rsc.org paper, the groups of @meganwright.bsky.social and Stuart Warriner investigate the metal-independent labeling of proteins using isocyanides.
pubs.rsc.org/en/content/artic...
#ChemBio #ChemSky #CovalentInhibitors

cool right?