Potassium ion homeostasis modulates mitochondrial function, say Adam James Waite, Daniel E. Gottschling and colleagues (Calico Life Sciences): rupress.org/jcb/article/...
#CellMetabolism #Metabolism #Genetics #Organelles #Mitochondria #Aging
In a screen to identify mutants that delay the decline in #mitochondria function with #aging, Waite, Gottschling et al. discover that potassium, the most abundant cation in cells, modulates mitochondrial membrane potential—a functional hallmark of mitochondrial health. rupress.org/jcb/article/...
Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/...
#CryoET
Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.
Glad to share the work from our group. We develop a method for visualizing subcellular structures in near-native plant cells.
doi.org/10.3389/fpls...
Measuring mitochondrial membrane potential | The EMBO Journal www.embopress.org/doi/full/10....
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
Pleased to receive 1st prize poster award at TSMRM. Shared my work optimizing sample preparation for cryo-soft X-ray tomography and its application in mitochondrial structure studies.
Thanks to the organizers for an inspiring meeting and great to reconnect with friends from Japan.
#mitoresearch
Using auxin-induced degron system in yeast, this study reveals that Fzo1 depletion causes abnormal mitochondrial inheritance and reduced mtDNA synthesis during the first cell division, worsening in subsequent divisions. It provides new insights into how Fzo1 loss leads to petite formation.
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Physiological roles of mitochondria dynamics in yeast cells.
Illustration of mitochondrial morphology phenotypes in yeast cells.
Scheme of the factors regulating mitochondria dynamics in yeast cells.
Happy to share my first review article "The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae".
microbialcell.com/researcharti...
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
Had an amazing time conducting research at Osaka University! Grateful for the support and experiences, thanks for featuring my story! (Graduated in 2023)
www.sci.osaka-u.ac.jp/en/chang-lin...
