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Adrian Mulholland

@adrianmulholla1

Professor of Chemistry, University of Bristol. Computational chemistry,enzyme catalysis, biomolecular simulation,HPC,antibiotic resistance.Views my own.

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21.11.2024
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Latest posts by Adrian Mulholland @adrianmulholla1

Basically the next election is going to come down to whether or not "generalised, non-specific anger at the system" outweighs "realisation that the alternative is a bunch of weird freaks with deeply eccentric policy views".

24.02.2026 13:29 πŸ‘ 64 πŸ” 20 πŸ’¬ 8 πŸ“Œ 2
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Uncertainties of enhanced rock weathering for climate-change mitigation - Nature Reviews Earth & Environment Enhanced rock weathering (ERW) is a carbon dioxide removal (CDR) strategy that converts atmospheric CO2 to stable carbonates by applying minerals to agricultural land. This Perspective discusses the p...

Enhanced rock weathering could help remove CO2 by spreading crushed Si-rich rock on soils

But scaling it up isn’t simple. Limited suitable rock, potential toxic elements, soil impacts, uncertain carbon tracking from land to ocean, and financing are major challenges

www.nature.com/articles/s43...

24.02.2026 08:25 πŸ‘ 15 πŸ” 6 πŸ’¬ 1 πŸ“Œ 2
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A potential late sequelae of measles after normal recovery.
Occurs in ~ 2/10,000. Fatal.
www.nejm.org/doi/full/10.... @nejm.org today

21.02.2026 14:48 πŸ‘ 193 πŸ” 77 πŸ’¬ 6 πŸ“Œ 4
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Why has it been so wet this winter? This winter has felt exceptionally wet for many parts of the UK, with repeated bouts of rain and very few prolonged dry spells.

Why has it been so wet this winter (in the UK)?

www.metoffice.gov.uk/blog/2026/wh...

19.02.2026 20:13 πŸ‘ 5 πŸ” 3 πŸ’¬ 1 πŸ“Œ 1
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Veronica Vaida: β€˜Some Harvard faculty expressed puzzlement at having a woman colleague’ The renowned physical chemist and environmental scientist on growing up in Romania and forging her career as a woman in the US in the 1970s

β€˜Many important moments in my career seemed entirely serendipitous, but sharing of ideas, collaboration and building of community was important to my work.’

20.02.2026 10:26 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 2

Gosh just from eyeballing the graph I wonder if anyone can think of something that might have happened around idk 2016 to cause a further deterioration?

20.02.2026 10:15 πŸ‘ 55 πŸ” 16 πŸ’¬ 3 πŸ“Œ 2
"Moderna's CEO announced the company will no longer invest in new Phase 3 vaccine trials for infectious diseases: 'You cannot make a return on investment if you don't have access to the U.S. market. Vaccines for Epstein-Barr virus, herpes, and shingles have been shelved.”
9:12 AM
Feb 12, 2026
604.8K Views

"Moderna's CEO announced the company will no longer invest in new Phase 3 vaccine trials for infectious diseases: 'You cannot make a return on investment if you don't have access to the U.S. market. Vaccines for Epstein-Barr virus, herpes, and shingles have been shelved.” 9:12 AM Feb 12, 2026 604.8K Views

In terms of what cures are being lost:

- Epstein-Barr virus is perhaps the major trigger for multiple sclerosis
- herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis
- shingles virus causes an intensely painful disease

13.02.2026 05:44 πŸ‘ 12542 πŸ” 6208 πŸ’¬ 444 πŸ“Œ 785

Indeed. According to Historia Anglorum, Cnut said β€œLet all the world know that the power of kings is empty and worthless”. Wise words.

12.02.2026 21:59 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Cnut revokes scientific findings on so-called β€œincoming tide”; promotes beach development

12.02.2026 21:43 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Prasad overruled FDA staff to reject Moderna's flu vaccine application The rejection is the latest instance of Vinay Prasad overruling career FDA scientists to place vaccines under harsher scrutiny.

Top FDA official Vinay Prasad overruled the agency’s reviewers--career scientists--when he refused to accept Moderna’s application for a new influenza vaccine www.statnews.com/2026/02/11/m...

11.02.2026 21:52 πŸ‘ 333 πŸ” 160 πŸ’¬ 29 πŸ“Œ 27
Banner image with screenshot of scientific article from nature Medicine, as well as two panels from the study method and results

Banner image with screenshot of scientific article from nature Medicine, as well as two panels from the study method and results

⚠️ Despite all the hype, chatbots still make terrible doctors. Out today is the largest user study of language models for medical self-diagnosis. We found that chatbots provide inaccurate and inconsistent answers, and that people are better off using online searches or their own judgment.

09.02.2026 17:07 πŸ‘ 358 πŸ” 168 πŸ’¬ 7 πŸ“Œ 33
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Extreme temperature events reshuffle the ecological landscape of the Southern Ocean - Nature Communications Satellite records reveal that Southern Ocean phytoplankton responds in contrasting ways to marine heatwaves and cold spells. These opposing impacts vary sharply by region, exposing distinct ecological...

New study uses #satellite records and shows that #SouthernOcean #phytoplankton responds in contrasting ways to marine #heatwaves and #cold spells. The impacts vary sharply by region, exposing distinct #ecological sensitivity to #climate -driven extremes. www.nature.com/articles/s41...

04.02.2026 09:01 πŸ‘ 72 πŸ” 36 πŸ’¬ 1 πŸ“Œ 1
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Australian tropical rainforest trees switch in world first from carbon sink to emissions source Researchers say carbon emissions change in Queensland tropical rainforests may have global climate implications

This research paper is the first time that a tipping point of a switch from a carbon sink to a carbon emission source in tropical rainforests has been identified clearly – not just for one year but for the last 20 years. Cause is a change in the local climate. www.theguardian.com/environment/...

03.02.2026 22:26 πŸ‘ 3054 πŸ” 1196 πŸ’¬ 107 πŸ“Œ 90
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Sunset after rain #Bristol

01.02.2026 20:43 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

It occurs to me that if there’s one thing that AI is going to make redundant it’s the dire BBC News website coverage of events via the mechanism of he said and then she said and then he said etc.

25.01.2026 12:56 πŸ‘ 63 πŸ” 11 πŸ’¬ 4 πŸ“Œ 1
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Landmark €4.55 billion investment in Ireland’s research sector and universities announced Plan targets research, education and innovation

β€˜The plan is about building capacity for Ireland’s future – in our people, our institutions and our economy' – James Lawless, minister for further and higher education.

24.01.2026 10:00 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Manchester city centre, painting by Michael Ashcroft.

22.01.2026 08:29 πŸ‘ 125 πŸ” 32 πŸ’¬ 1 πŸ“Œ 1
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Predicting protein interfaces in the age of AlphaFold: Why dynamics and disorder remain a challenge Two recent studies in Cell Systems show why protein dynamics matter for prediction. By moving beyond static structures and embracing the dynamic β€œjigglings and wigglings” that Richard Feynman famously...

Why protein dynamics matter and AlphaFold isn't the answer to everything.
www.cell.com/cell-systems...

21.01.2026 17:18 πŸ‘ 30 πŸ” 8 πŸ’¬ 2 πŸ“Œ 0
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We are thrilled to be celebrating the 25th anniversary of our fellowship programme with the Wolfson Foundation, whose support has given researchers the tools and expertise to take their research to the next level. Since 2000, the scheme has supported 852 grant holders from 16 countries.
#RSGrants

21.01.2026 09:49 πŸ‘ 10 πŸ” 1 πŸ’¬ 4 πŸ“Œ 0
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Antarctic penguins have radically shifted their breeding season – seemingly in response to climate change Changing temperatures may be behind change in behaviour, which experts fear threatens three species’ survival

www.theguardian.com/world/2026/j...

20.01.2026 09:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Lessons from Rwanda’s response to the Marburg virus outbreak - Nature Medicine Nature Medicine - Lessons from Rwanda’s response to the Marburg virus outbreak

Lessons from Rwanda’s response to the Marburg virus outbreak

www.nature.com/articles/s41...

19.01.2026 18:43 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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'Europe is at a total loss': Russia gloats over Greenland tensions The BBC's Russia editor Steve Rosenberg analyses why pro-Russian government papers are full of praise for Donald Trump's desire to buy Greenland.

www.bbc.co.uk/news/article...

19.01.2026 18:22 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Are we honestly doing the World Cup over there? For real?

17.01.2026 18:30 πŸ‘ 725 πŸ” 86 πŸ’¬ 61 πŸ“Œ 19
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wikipedia turns 25 today! the last unenshittified major website! backbone of online info! triumph of humanity! powered by urge of unpaid randos to correct each other! somehow mostly reliable! "good thing wikipedia works in practice, because it sure doesn't work in theory" - old wiki adage

15.01.2026 13:47 πŸ‘ 12542 πŸ” 4028 πŸ’¬ 95 πŸ“Œ 306
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Artificial intelligence tools expand scientists’ impact but contract science’s focus - Nature Artificial intelligence boosts individual scientists’ output, citations and career progression, but collectively narrows research diversity and reduces collaboration, concentrating work in data-rich a...

One of my concerns with AI-assisted research in biology is that we're already looking only in the lamplight and AI incentivizes us to narrow the beam. Seems like it's happening...
www.nature.com/articles/s41...

15.01.2026 16:08 πŸ‘ 148 πŸ” 43 πŸ’¬ 7 πŸ“Œ 7
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If you are an early-stage career scientist πŸ§‘β€πŸ”¬ using biomolecular simulations the BioExcel Summer School is for you!

Running since 2018 it always receives outstanding reviews

Apply here ➑️ bioexcel.eu/4ooy

Deadline for applications: 1st February!

#training #molecularsimulations #community

14.01.2026 08:54 πŸ‘ 5 πŸ” 6 πŸ’¬ 0 πŸ“Œ 1

Incredible article which points out that it often collectively costs more to apply for scarce research funding than the funds awarded to the successful proposals.

What an absurd system we've built in the service of efficiency and competition.

www.nature.com/articles/d41...

13.01.2026 20:55 πŸ‘ 267 πŸ” 98 πŸ’¬ 11 πŸ“Œ 20
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American biologist Toby Kiers wins 'Environment Nobel' for shedding light on hidden fungal networks.

Beneath the surface of forests, grasslands and farms across the world, vast fungal webs form underground trading systems to exchange nutrients

u.afp.com/SXR8

14.01.2026 08:59 πŸ‘ 19 πŸ” 11 πŸ’¬ 0 πŸ“Œ 1
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Archaeon’s lack of metabolism challenges definitions of life A question that is not the same as asking whether something is alive

What is life? As Philip Ball explores, it's surprisingly hard to define.

13.01.2026 11:32 πŸ‘ 5 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Uppgifter om hundratals dΓΆdade demonstranter i Teheran Protesterna i Iran Γ€r sΓ₯ omfattande att sΓ€kerhetsstyrkorna inte rΓ€cker till fΓΆr att hΓ₯lla tillbaka demonstranterna.

I was not being hyperbolic. Reports of hundreds of protestors killed in Tehran alone. I expect real numbers to be much higher, as news isn't getting out due to the communications blackout. Silence is complicity. Don't look away. #Iran

www.dn.se/varlden/uppg...

10.01.2026 16:05 πŸ‘ 13 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0