Cláudia Gil

Thank you. It was fantastic to read your discussion on this topic.

Thank you Carlos!

Check out this great commentary by @bartolomuccilab.bsky.social and @johnspeakman4.bsky.social on our recent paper, that investigates the role of #foodinsecurity on energy homeostasis and #adiposity in mice 💡

9/9 This work would also not have been possible without the funding of @lundbeckfonden.bsky.social, Novo Nordisk Foundation and the Copenhagen Bioscience PhD Programme to whom I'm grateful for the support 🙌

8/9 This milestone results from my work during the PhD but also from the incredible support and collaboration of the co-authors, @lundjens.bsky.social, @jzylicz.bsky.social, @pranea.bsky.social, Thorkild Sørensen, @clemmensenc.bsky.social and my amazing colleagues from @cbmr.science @koebenhavns_u

7/9 With this work, we underline the role of food insecurity as a promotor of energy storage in adipose tissue, highlighting the importance of addressing the roots of obesity in populations with a limited access to nutritious foods 🍎🥗

6/9 To dissect the biological mechanisms behind this response, we looked into the adipose tissue transcriptional signature driven by food insecurity in male lean mice, unveiling potential mechanisms of lipid regulation under food insecurity situations 🧬

5/9 Surprisingly, a significant reduction in lean mass was also observed in male mice exposed to high-fat diet, even with the pronounced positive energy balance with this type of diet 🤯

4/9 After a 4-week exposure to food insecurity, and despite the maintenance of body weight, male and female mice increased their fat reserves 📈, while their lean mass was reduced 📉

3/9 To understand how food insecurity could be a driver of increased adiposity, we developed a novel mouse model of food insecurity, by exposing C57BL/6J mice to an intermittent access to standard food 🐭🧀

2/9 Intrigued by the high prevalence of obesity in food-insecure populations, and the evolutionary rationale behind the insurance hypothesis (doi.org/10.1017/S014...), we started thinking of a way of modelling food insecurity in mice to further explore this association.

Food insecurity promotes adiposity in mice Objective The obesity epidemic, driven by a complex interplay of environmental and biological factors, remains a significant global health challenge. Herein, we investigate the impact of food insecu...

🌟 Exciting News! 🌟
I am thrilled to share that my first paper as the first author, Food insecurity promotes adiposity in mice, is now published in #ObesityJournal #ObesitySociety

doi.org/10.1002/oby....

#Foodinsecurity #Obesity #PhD

1/9🧵👇

I had the pleasure to present our recent research at the wonderful University of Granada this week.

Thank you to @pranea.bsky.social for inviting me :)

I'm happy to have contributed to this amazing study 🙌 check the thread below to know more about how short-term overfeeding affects mice metabolism 🐭

ERC grant funds research to support weight loss maintenance Associate Professor Christoffer Clemmensen from the University of Copenhagen has received an ERC Consolidator Grant for a project that aims to develop new therapeutic interventions that will help peop...

1/3 Kicking off my 🦋 journey with news that my lab has been awarded an ERC Consolidator Grant! Feeling incredibly proud and grateful. The project builds on our long-term focus: homeostatic control of body weight and pharmacological approaches for sustained weight loss. cbmr.ku.dk/news/2024/er...