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Biological Sciences

@sotonbiosciences

School of Biological Sciences at the University of Southampton unisouthampton.bsky.social tackling the world’s greatest life science challenges.

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20.11.2024
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Latest posts by Biological Sciences @sotonbiosciences

@engineering-soton.bsky.social @mjtplantbiology.bsky.social @drmicrowill.bsky.social @sotonbiosciences.bsky.social

09.03.2026 10:22 👍 3 🔁 2 💬 0 📌 0
Artist’s impression of two large spinosaurus dinosaurs standing in shallow water during a smoky prehistoric wildfire scene, with flying reptiles overhead and one dinosaur roaring while the other stands nearby. Credit: Anthony Hutchings.

Artist’s impression of two large spinosaurus dinosaurs standing in shallow water during a smoky prehistoric wildfire scene, with flying reptiles overhead and one dinosaur roaring while the other stands nearby. Credit: Anthony Hutchings.

wearing round glasses, a green tweed jacket, white shirt, and patterned tie, smiling while seated in an office or lab workspace. Behind him are shelves with files, a computer monitor, and a fossil-like sculpture

wearing round glasses, a green tweed jacket, white shirt, and patterned tie, smiling while seated in an office or lab workspace. Behind him are shelves with files, a computer monitor, and a fossil-like sculpture

Proud to celebrate our dinosaur expert Dr Neil Gostling and former student Thomas Land for their parts in the new Spielberg documentary The Dinosaurs on Netflix 🦕

Dr Gostling researched Spinosaurus habits, and Thomas was a science researcher.

Find out more: www.southampton.ac.uk/news/2026/03...

06.03.2026 11:06 👍 23 🔁 11 💬 0 📌 1
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And check out the #FirstPerson interview with Miguel Ramirez-Moreno, where he talks about what sparked his interest in research, breaks down his work in simple language and discusses his plans for future studies.

Read: doi.org/10.1242/dmm....

05.03.2026 12:00 👍 2 🔁 1 💬 0 📌 0
Images showing how expressing human Tau in the Drosophila wing reduces the size of the posterior compartment. Panels include: a schematic of larval and adult wings highlighting the posterior region; fluorescent wing discs expressing control mCD8::Cherry or mCherry‑tagged human Tau with E‑cadherin staining; quantification plots comparing posterior/anterior size ratios; and adult wings with the posterior compartment outlined, demonstrating that Tau isoforms 0N4R and 2N4R significantly shrink this region.

Images showing how expressing human Tau in the Drosophila wing reduces the size of the posterior compartment. Panels include: a schematic of larval and adult wings highlighting the posterior region; fluorescent wing discs expressing control mCD8::Cherry or mCherry‑tagged human Tau with E‑cadherin staining; quantification plots comparing posterior/anterior size ratios; and adult wings with the posterior compartment outlined, demonstrating that Tau isoforms 0N4R and 2N4R significantly shrink this region.

@miguelrmphd.bsky.social, Douglas Watt Allan, Amritpal Mudher & co model Tau-induced neurotoxicity in the #Drosophila wing, enabling a rapid, genetically tractable in vivo system for #tauopathies studies.

Read doi.org/10.1242/dmm....

@sotonbiosciences.bsky.social @unisouthampton.bsky.social

05.03.2026 12:00 👍 3 🔁 4 💬 1 📌 0
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Here's your sign! Why you need to attend the Science and Engineering Day 2026?

📅 Saturday 14 March 2026
⏰ 10:30 – 16:30
📍Highfield Campus and Boldrewood Innovation Campus
👉 Tickets: www.sotsef.co.uk/SED 🔍

#SOTSEF #WeAreUoS #BSW26 @uosmedia.bsky.social

03.03.2026 16:27 👍 2 🔁 6 💬 0 📌 0

In our latest work, we characterise the Tmn defence system. We reveal plasmolysis as a new way to block phage infection, dramatically reducing secondary infections.

03.03.2026 19:55 👍 27 🔁 19 💬 1 📌 1
A bat flying through the air

A bat flying through the air

From caves to crops: Dr Veronica Zamora-Gutierrez is leading new research funded by @leverhulme.ac.uk to explore the hidden value of bat guano and how protecting bats also matters for food security.

Read more in the Leverhulme Trust newsletter: www.flipsnack.com/leverhulmetr...

02.03.2026 14:37 👍 12 🔁 6 💬 0 📌 1

Hiring two postdocs, 3-years each, at @unisouthampton.bsky.social. We're investigating bat guano in Mexico

One postdoc in my group - plant/soil micro/microbiome: tinyurl.com/2zu8nrmv

One postdoc in bat ecology + ecoservices: tinyurl.com/27attrsc

Deadline March 30

@sotonbiosciences.bsky.social

26.02.2026 09:07 👍 1 🔁 2 💬 0 📌 0
A promotional poster for the Southampton Science and Engineering Festival and the University of Southampton. The event is titled “The science of Jurassic Park: Talk + Film screening + Q&A” presented by Dr Neil Gostling. It takes place at Avenue Campus on Tuesday 10th March from 18:00 to 22:00. The poster includes a circular photo of a person wearing a vest and lanyard, standing beside what appears to be a model or sculpture of a dinosaur head. At the bottom, there is a dark blue banner stating “Book your FREE tickets” with a link: bit.ly/SOTSEF26JurassicNight. The hashtag #SOTSEF appears in the lower right corner.

A promotional poster for the Southampton Science and Engineering Festival and the University of Southampton. The event is titled “The science of Jurassic Park: Talk + Film screening + Q&A” presented by Dr Neil Gostling. It takes place at Avenue Campus on Tuesday 10th March from 18:00 to 22:00. The poster includes a circular photo of a person wearing a vest and lanyard, standing beside what appears to be a model or sculpture of a dinosaur head. At the bottom, there is a dark blue banner stating “Book your FREE tickets” with a link: bit.ly/SOTSEF26JurassicNight. The hashtag #SOTSEF appears in the lower right corner.

Get ready for a roar-some evening! Join Dr Neil Gostling for the screening of Jurassic Park, followed by a discussion around the science of the film, and the science in reality!

Ticket: bit.ly/SOTSEF26Jura...
#SOTSEF #WeAreUoS #BSW26 @sotonbiosciences.bsky.social @unisouthampton.bsky.social

16.02.2026 13:31 👍 2 🔁 2 💬 0 📌 0

Join us 4 #SOTSEF👇😀! with Masters students &
Secret Life of Organoids, Inner working of Cells,
Health Innovations 🏃‍♂️ @clarkinbonebiol.bsky.social @fnobrega.bsky.social 🦠 @nelani.bsky.social Microbes, Mood & Murals 🎨 @jt8teeling.bsky.social & Sci of Jurassic Park 🦖! @neilgostling.bsky.social #BSW26

14.02.2026 11:03 👍 5 🔁 5 💬 0 📌 0
A brain made up of multiple coloured dots on a black background

A brain made up of multiple coloured dots on a black background

Professor Amritpal Mudher is part of a team of scientists who have developed a drug to prevent the build-up of Tau protein in the brain, which could pave the way for more effective treatments for neurogenerative diseases like Alzheimer's.

Find out more: www.southampton.ac.uk/research/hig...

06.02.2026 10:53 👍 2 🔁 0 💬 0 📌 0
A methylome-derived m6-dAMP trigger assembles a PUA-Cal-HAD immune filament that depletes dNTPs to abort phage infection Bacteria must distinguish phage attack from normal homeostatic processes, yet the danger signals that trigger many defence systems remain unknown. Here, we show that a PUA-Calcineurin-CE-HAD module from Escherichia coli ECOR28 confers broad anti-phage protection by binding Dam-methylated deoxyadenosine monophosphate (m6-dAMP) generated during phage-induced chromosome degradation. Ligand binding converts a preassembled PUA-Calcineurin-CE hexamer loaded with six HAD phosphatases into a polymerising filament. The filament acts as a high-flux dNTP sink through a two-enzyme cascade: HAD first dephosphorylates dATP to dADP, and Calcineurin-CE then converts dADP to dAMP. dNTP collapse halts phage replication and enforces abortive infection. Multiple mobile-element DNA mimic proteins block filament assembly, revealing a direct phage counter-defence. More broadly, our findings extend a conserved, cross-kingdom paradigm of immune filament assembly to nucleotide-depletion antiviral defence and suggest modified-nucleotide sensing by related PUA-Calcineurin-CE modules as a widespread, underappreciated bacterial strategy. ### Competing Interest Statement The authors have declared no competing interest. NIHR Southampton Biomedical Research Centre, https://ror.org/01qqpzg67, Postdoctoral Bridging Fellowship F.L.N. is supported by a Wessex Health Partners (WHP) and National Institute for Health and Care Research Wessex Experimental Medicine Network (NIHR WEMN), Seed fund National Institutes of Health, GM145888, U24 GM129539) Maloris Foundation Memorial Sloan Kettering Cancer Center, P30-CA008748 Simons Foundation, SF349247 New York State Assembly

Preprint out: We characterise PUA-Cal-HAD, a widespread bacterial antiphage defence family. An infection cue switches a preassembled complex into an immune filament that drains dNTPs via a coupled two-enzyme cascade, and phage DNA mimics can block filament assembly (anti-polymerisation).

17.01.2026 14:52 👍 34 🔁 19 💬 1 📌 0

Thoroughly enjoying our @sotonbiosciences.bsky.social Away Day. Lots of good discussion about the future of teaching, KEE and how we're going to keep delivering world class research. Great turnout as well, plus lunch was yum too!

16.01.2026 13:21 👍 2 🔁 1 💬 0 📌 0
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Next-generation phage therapeutics for combating antibiotic-resistant infections at University of Southampton on FindAPhD.com PhD Project - Next-generation phage therapeutics for combating antibiotic-resistant infections at University of Southampton, listed on FindAPhD.com

PhD studentship available: Join the phage frontline against AMR! 🧫 🔬
Funded by Wessex Medical Research × Rosetrees Trust.
With @fnobrega.bsky.social, Prof Saul Faust (NIHR Southampton), Dr Liz Sheridan (NHS Dorset).
Info & Apply → www.findaphd.com/phds/project...
Email me for informal enquiries

17.01.2026 00:25 👍 9 🔁 5 💬 0 📌 0
Dark and light blue text on a sky blue background that reads: University of Southampton, Call for exhibitors closing soon, Southampton Science and Engineering Festival, 6th – 15th March 2026 Visit the Exhibitor Area at sotsef.co.uk/sed-registration, #SOTSEF. Accompanying image: a young girl with a padded purple jacket, wearing a VR headset and holding a VR controller in one hand, looking up in amazement.

Dark and light blue text on a sky blue background that reads: University of Southampton, Call for exhibitors closing soon, Southampton Science and Engineering Festival, 6th – 15th March 2026 Visit the Exhibitor Area at sotsef.co.uk/sed-registration, #SOTSEF. Accompanying image: a young girl with a padded purple jacket, wearing a VR headset and holding a VR controller in one hand, looking up in amazement.

The call for #Southampton #Science and #Engineering Festival 2026 at @unisouthampton.bsky.social - including Science and Engineering Day, is CLOSING SOON!

↘️ Visit sotsef.co.uk/sed-registration to find out more and register.

🗓️ DEADLINE: Monday 12th January 2026

#SOTSEF🔍
#BSW25 #WeAreUoS

06.01.2026 13:26 👍 2 🔁 2 💬 0 📌 1
A Red-brick building with large windows and a stone insignia, under a clear blue sky. A vibrant green tree stands to the left. Large white text reading "Happy New Year" is in the sky, adorned with sparkling stars and the University of Southampton emblem in the corner.

A Red-brick building with large windows and a stone insignia, under a clear blue sky. A vibrant green tree stands to the left. Large white text reading "Happy New Year" is in the sky, adorned with sparkling stars and the University of Southampton emblem in the corner.

Happy New Year from everyone at the University of Southampton! ✨

Whether you’re studying, researching, teaching or supporting our University, we can’t wait to see what 2026 brings.

01.01.2026 09:00 👍 11 🔁 3 💬 0 📌 0
Sparklers light up the stage at the end of the 2025 winter graduation ceremony

Sparklers light up the stage at the end of the 2025 winter graduation ceremony

A huge congratulations to all of our 2025 graduates - it was brilliant to celebrate with you today. Wishing you all the very best for the future #WeAreUoS

17.12.2025 13:58 👍 0 🔁 0 💬 0 📌 0
Postgraduate students in front of a large sign at the symposium

Postgraduate students in front of a large sign at the symposium

The School of Biological Sciences co-organised the 2025 International Symposium for Young Scholars in Basic Medical Sciences, which took place in Jinan, China.

The event welcomed nearly 80 young scholars and postgraduate students from 12 countries.

Read more: bit.ly/4aYvilQ

16.12.2025 10:11 👍 0 🔁 0 💬 0 📌 0
A scientist in a lab coat and safety goggles uses a pipette to transfer liquid into a small tube, surrounded by various lab equipment and bottles with blue and red caps. Shelves with additional lab supplies are visible in the background.

A scientist in a lab coat and safety goggles uses a pipette to transfer liquid into a small tube, surrounded by various lab equipment and bottles with blue and red caps. Shelves with additional lab supplies are visible in the background.

Close-up illustration of multiple rod-shaped bacteria with hair-like structures and long whip-like appendages, set against a black background. The bacteria appear pink and fuzzy, with intricate details on their surface.

Close-up illustration of multiple rod-shaped bacteria with hair-like structures and long whip-like appendages, set against a black background. The bacteria appear pink and fuzzy, with intricate details on their surface.

Toxic bug E. coli uses a secret weapon to survive in our gut even when it is being treated with antibiotics 🧪

Our scientists have unmasked a super-pump inside the bacteria that is activated by our stomach acid.

Read more 👉 https://tr.pulse.ly/gomzlvmqrd

04.12.2025 09:29 👍 3 🔁 2 💬 0 📌 0
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It was great to have Cat McColgan visit our lab to show us the etching prints she had created demonstrating plasmolysis, a mode of action that bacteria use to defend themselves against phages 🧫

Instagram: cb_mccolgan
Website: www.cbmccolgan.com

02.12.2025 11:25 👍 3 🔁 1 💬 1 📌 0
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Love RNA biology and care about reproducibility? I’m co-editing a @bio-protocol.bsky.social special issue with @marionhogg.bsky.social & Renate Weizbauer —focusing open access and transparent RNA detection protocols.
Submit yours today - en.bio-protocol.org/content17
#OpenScience #ReproRNAbiology

12.07.2025 13:34 👍 12 🔁 8 💬 0 📌 3
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Advancing urinary tract infection treatment through on-chip technological innovation at University of Southampton on FindAPhD.com PhD Project - Advancing urinary tract infection treatment through on-chip technological innovation at University of Southampton, listed on FindAPhD.com

PhD Opportunity: Advance UTI treatment with on-chip tech! 🔬🧫
Work at the microbiology-bioengineering interface with Hywel Morgan, @fnobrega.bsky.social and me.
Program EPSRC/MOD CISDnS CDT cisdns-cdt.ac.uk
Co-funded by IfLS Southampton
tinyurl.com/infoUTI
tinyurl.com/applyUTI
Deadline: 8 Dec 2025

26.11.2025 11:24 👍 7 🔁 8 💬 0 📌 1
Advert for PhD studentship on PIF protein in wheat with Matthew Terry, University of Southampton

Advert for PhD studentship on PIF protein in wheat with Matthew Terry, University of Southampton

I have a PhD studentship available to work on PIF proteins in wheat with Stephen Pearce @rothamsted.bsky.social and @colleendrapek.bsky.social at Phytoform labs. Any reposts greatly appreciated.

06.11.2025 11:41 👍 5 🔁 5 💬 0 📌 0

Thrilled to share the core of my PhD work, now published in NAR!

This project was a true collaborative effort across multiple teams, and it was a joy to bring it to life.

Huge thanks to everyone involved, and especially to @fnobrega.bsky.social for the incredible support and guidance 🙏🏻

🧵1/5

22.11.2025 18:11 👍 18 🔁 7 💬 1 📌 1
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New collection of bacteria-eating viruses to tackle hospital superbug New collection of bacteria-eating viruses to tackle hospital superbug

Our researchers have mapped 52 different bacteria-eating viruses (phages) in the fight against antibiotic resistant hospital superbugs. The research was made possible by Bowel Research UK.

Find out more 👉 https://southampton.pulse.ly/czdvrfqaem

21.11.2025 16:57 👍 3 🔁 1 💬 0 📌 0
Dark and light blue text on a sky blue background that reads: University of Southampton, Call for exhibitors now open, Southampton Science and Engineering Festival, 6th – 15th March 2026 Visit the Exhibitor Area at sotsef.co.uk/sed-registration, #SOTSEF. Accompanying image: a young girl with a padded purple jacket, wearing a VR headset and holding a VR controller in one hand, looking up in amazement.

Dark and light blue text on a sky blue background that reads: University of Southampton, Call for exhibitors now open, Southampton Science and Engineering Festival, 6th – 15th March 2026 Visit the Exhibitor Area at sotsef.co.uk/sed-registration, #SOTSEF. Accompanying image: a young girl with a padded purple jacket, wearing a VR headset and holding a VR controller in one hand, looking up in amazement.

The call for #Southampton #Science and #Engineering Festival 2026 at @unisouthampton.bsky.social - including Science and Engineering Day, is NOW OPEN!

↘️ Visit sotsef.co.uk/sed-registration to find out more

🗓️ Deadline for contributors: Monday 12th January 2026

#SOTSEF🔍
#BSW25 #WeAreUoS

20.11.2025 17:05 👍 7 🔁 3 💬 0 📌 0
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⭐ NAR Breakthrough! ⭐

A community-driven collection uniting 52 phages, 74 Klebsiella isolates, and extensive genomic + phenotypic data — all freely available at klebphacol.org.
🧬 Learn more: doi.org/10.1093/nar/...
@fnobrega.bsky.social @danielarothschild.bsky.social #antimicrobialresistance

20.11.2025 18:01 👍 11 🔁 6 💬 1 📌 2
A scientist wearing a blue lab coat and gloves is working in a laboratory. They are using a pipette to transfer liquid into a petri dish inside a fume hood. Several bottles of liquid and lab equipment are visible in the background.

A scientist wearing a blue lab coat and gloves is working in a laboratory. They are using a pipette to transfer liquid into a petri dish inside a fume hood. Several bottles of liquid and lab equipment are visible in the background.

Could weight loss drugs like Ozempic help to boost the effectiveness of breast cancer treatments in women with obesity?

Our researchers have been funded by Against Breast Cancer to investigate.

Read more 👉 https://tr.pulse.ly/vitxspwdgm

18.11.2025 12:29 👍 3 🔁 1 💬 0 📌 0
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The annual VertZoo trip to @morethanadodo.bsky.social for a comparative anatomy study practical is always fun, but this year @sotonbiosciences.bsky.social is joined by @unisouthampton_wsa! The museum refurb looks amazing, modern but completely in keeping @unisouthampton.bsky.social #ArtAndScience

17.11.2025 15:58 👍 8 🔁 5 💬 0 📌 0
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This week is #AntiBullyingWeek ! To celebrate what makes us unique and to raise awareness we're wearing #OddSocks ! Let's empower everyone to use their #PowerForGood to speak out, support others, and build a world where kindness wins.

@sotonbiosciences.bsky.social @unisotontechs.bsky.social

12.11.2025 12:15 👍 5 🔁 1 💬 1 📌 0