Rheum Cat

Just a tiny baby yet he takes up the entire bed 🧡

this is like

the thesis statement of our times

Below 10% paylines, you could apply 15 times - once per cycle, every cycle before your R01 lapses - and have <80% chance of getting 1 grant funded.

That's for 100% funding probablity at 10th percentile. 2025 was 50% probability at 10th percentile.

Unsustainable.

Lake Wobegone-ass funding lines.

a tux cat logging onto my laptop

never stops being weird how much people will deduce about you from a single post they didn’t even read correctly. anyways, thanks for all the kind words friends. i appreciate it, and so does ms. perfect princess.

Ummm... Excuse me, can I help you find something?

Little Miss Hone painting, my photo of it (A five year old girl in a fancy hat feeds an angry tabby kitten)

😾

One of my favorites

Overhead photo featuring a table of white plates full of colorful food.

Iftar, Day 17

Here is the "effective payline" for each institute, estimated (by Claude) as the percentile where one can expect 80% probability of funding from a logistic regression fit. The effective payline has gone from a historic ~12% to 6% in 2025.

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

Like again, it's really easy to come here on this internet and dunk on people and yell at people. But that is not going to solve anything. And apparently the answer here for this person is to just give up and let people die. Thank goodness for public health people who keep on trying.

Photo strips of moments from the Opalite music video surround the title of the presentation, “The Opalite Music Video: An Analysis by Goose Lavender.” There is also a slew of 90s clip art. Note: moving forward, Opalite Music Video will be shortened to OMV and I will not be describing the clip art. This is for the sake of clarity and the sharing of information.

The Opalite Music Video: An Analysis by Goose Lavender

Make sure you read alt text on every slide! I clarify points and add so much detail there.

Mm crusty bread

A black cat sits next to some shelves

Cat tax

But do let me know if I’m veering into toxic positivity because no one wants that

San Francisco City Hall illuminated in blue at night, framed by trees on both sides.

SF City Hall went blue for Colorectal Cancer Awareness Month! At the lighting, we announced the launch of our Young Onset Colorectal Cancer Program at UCSF.
Colorectal cancer is now the leading cause of U.S. cancer deaths in people younger than 50.
More about the program ➡️ https://ucsfh.org/46HBJHo

UCSF Staff and partners with inflatable colon for colorectal cancer awareness

March is Colon Cancer Awareness Month. Our Office of Community Engagement has a handy list of resources on colon cancer: linktr.ee/UCSFCancerCe... #ColorectalCancerAwareness

Convince some wellness influencer to try it

Given the Nazis with eponyms in rheum, I’d have to agree

Please apply and add fiber back to the food pyramid

A handwritten letter, stickers, friendship bracelets and an autographed Dance Fever CD

a close up of a pink, blue and purple friendship bracelet with “Bek loves Seri” written in beads

do you guys mind if I cry??
@bekutation.swifties.social has completely turned my 2026 around with a single kind gesture. this was one of the greatest gifts I have ever received. I will never be taking off this bracelet 🥹💗💜🩵 BLUESKY BESTIES 4 LIFE!!! 🦋🦋🦋

I will validate, distract, and pep talk into the resubmission

I volunteer to take these hits for you

As @nasingh.bsky.social can attest, I am zero bothered by rejections

I would really love it if we moved past having podcast hosts without germane expertise running our regulatory apparatuses. Anyway, take 2, I suppose. Let’s see how long this one lasts.

If you have gotten to the point that you are gladdened to learn that children have been sickened by infectious diseases, please pause and reflect for a moment.

What lore

Brown sequard injected ground up animal testicles

RIP Brown-Séquard the manosphere losers would have loved you.

I think vaccines should be mandatory and I believe children have their own inalienable rights. However, that’s not the legal stance in this country, where children are considered property. So…either you customize your message for your audience or you sneer at them. Guess which one works

A black cat looks over his shoulder on the white comforter — you can see the book I’m reading, gold cover, Dorothy Sayers Thrones Dominions. We went to bed at 7pm

Do I know how to party on a Fri night or what

Has been pretty vindicating that the people on Twitter we used to argue with about COVID actually got their chance to run things and they each turned out to be every bit the incompetent fuckwit that we knew they’d be