Ivan Huc Group

Ivan Huc Group @akhuc.bsky.social at the Banquet last night #Foldamers #Symposium

Congratulations to Manu for his great communication on his (numerous!) PhD works on DNA mimics at the Foldamer Symposium! 🧬

Structure-based design of an aromatic helical foldamer–protein interface The starting point of this study is the solid state structure of a complex between human carbonic anhydrase II (HCAII) and a helically folded tetradecaamide aromatic foldamer with a nanomolar HCAII li...

Our new article published in Chem. Science on improving protein contact by varying foldamer side chains is now available!

pubs.rsc.org/en/content/a...

Interfacing B‐DNA and DNA Mimic Foldamers Helical aromatic oligoamide DNA mimic foldamers that reproduce the shape and charge distribution of duplex B-DNA have been interfaced with DNA duplexes by means of a new linker that serves both as a ...

Very happy to share our work on DNA/foldamer chimeras ! This was achieved thanks to a hairpin linker on which a DNA mimic foldamer can be anchored ⚓
onlinelibrary.wiley.com/doi/full/10....

The countdown is on! Registrations close in three days on Friday 27 June, 23:59 GMT.

🔗Register now: foldamers2025.com

#conference #foldamers #chemistry #chemsky

@kingsnmes.bsky.social @andrecobb.bsky.social @anbismillah.bsky.social

Display selection of peptide ligands for helical aromatic foldamers Helical aromatic oligoamide foldamers with a cluster of five biogenic side chains at their surface were designed and synthesized. Display selection of thioether macrocyclic peptides against these targ...

🪢Happy to share that our collaborative work with the Suga lab has been accepted! If you want to know about display selection of macrocyclic peptides against helical foldamers, please check the article here: pubs.rsc.org/en/content/a...

Development of Aromatic Foldamer Building Blocks Bearing Multiple Biogenic Side Chains Aromatic oligoamides, with their intrinsic rigidity and well-defined conformations, are recognized for their potential in medical applications. Similar structures are present in several naturally occurring antibiotics and have been explored for their ability to bind to various proteins and B-DNA (canonical right-handed DNA helix). This study introduces a synthetic approach to produce quinoline amino acid monomers bearing diversified side chain combinations in positions 4, 5, and 6 of the quinoline ring, designed to enhance the side chain density on helical foldamers. By increasing the number of side chains on each monomer, we aim to mimic the dense side chain presentation of α-peptides, thus improving the potential for protein surface recognition. This synthetic strategy involves efficient functionalization through cross-coupling reactions, enabling the installation of diverse side chains at strategic positions on the quinoline ring. The process has been optimized for automated solid-phase synthesis, successfully producing a 20-unit oligoamide with good purity. This foldamer, featuring multiple cationic, anionic, polar, and hydrophobic side chains, demonstrates the potential for molecular recognition in drug discovery and therapeutic applications. The methodology described here represents a significant advancement in the construction of aromatic oligoamide foldamers, providing a robust platform for further exploration of biological systems.

You can check out this paper to know how we achieved automated synthesis of aromatic oligoamide foldamers with a very wide variety of biogenic side chains! 🤖 pubs.acs.org/doi/10.1021/...

The collections feature authors including @hayneschemlab.bsky.social, @akhuc.bsky.social, @karabren.bsky.social, @demirselly.bsky.social, @unsworthchem.bsky.social, @chemashlee.bsky.social, @bessettatiana.bsky.social, @catalysis-lab.bsky.social & @flpchemist.bsky.social, with more articles to come!

DNA Mimic Foldamer Recognition of a Chromosomal Protein Biomolecular mimics are intended to outperform their natural counterparts. However, B-DNA surface mimicry to target DNA-binding proteins has long remained underdeveloped. We have introduced helical a...

Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬

onlinelibrary.wiley.com/doi/full/10....

That's a German tradition for defenses — many group members participate in the making of the PhD hat !

Congratulations to the new doctor Shuhe Wang for this Chem. Sci. publication on bundles of three aromatic helices! 🏗️
pubs.rsc.org/en/content/a...

Interrogating the potential of helical aromatic foldamers for protein recognition A biotinylated helical aromatic oligoamide foldamer equivalent in size to a 24mer peptide was designed without any prejudice other than to display various polar and hydrophobic side chains at its surf...

We are pleased to announce that our communication on protein recognition with helical aromatic foldamers has been published in Organic & Biomolecular Chemistry! @roysocchem.bsky.social 🧪 A cornerstone for some of our current and future projects 👀
pubs.rsc.org/en/content/a...

Check out our article in @angewandtechemie.bsky.social about the design of foldamers that aggregate into abiotic quaternary structures 🧩 Congrats to Shuhe! onlinelibrary.wiley.com/doi/10.1002/...