Sudheer Peneti Ph.D

Really nice highlight of our recent paper on cytoplasmic partitioning by physical instabilities!

See you at @apsphysics.bsky.social Global Physics Summit Denver @agrigas.bsky.social @somiealo.bsky.social @manningresearch.bsky.social

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity!

www.nature.com/articles/s41...

Thrilled to see this new preprint from Rupprecht lab out — happy I could contribute with my rotating rings. May the science keep spinning. 🔄✨

💡 Have you ever wondered how #circulating #tumor cells squeeze through narrow #capillaries during hashtag#metastasis ?

💥 We did, check out our latest publication just out #NatureMaterials: rdcu.be/eZHxJ

Thanks Julia!🙂

My PhD work showed that vimentin is not only a passive marker of EMT, but plays an active role in collective migration, controlling the mechanics of epithelial leader cells. I am grateful to my supervisors, Rene-Marc & Benoit Ladoux, as well as to all the co-authors.
www.biorxiv.org/content/10.6...

Interesting work here…

Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions Excess area of the nuclear lamina, observed as wrinkles in a round nucleus, enables cell migration through constricting channels.

Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions | Science Advances www.science.org/doi/10.1126/...

Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions Tumour development and progression are associated with biophysical alterations that manifest across multiple spatial scales, from the subcellular to multicellular tissue scale. While cells can dynamic...

How do cells adapt their volumes when they proliferate and form a multicellular mass in 3D? If you have wondered about this or work with 3D in-vitro systems, then you will be happy to read our paper now on bioRxiv!
www.biorxiv.org/content/10.1...

See the thread 🧵 below for more information.

Perspective @jcb.org by Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...

How cells move and change shape—and why it matters for our health - News Inside each of your cells, there’s a microscopic scaffolding that helps determine what the cell looks like, how it moves, and how it responds to its surroundings. This internal structure, called the c...

How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding.
www.rockefeller.edu/news/38446-h...

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...

Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids Highlighted Article: A bioinert confinement system enables dissection of how stiffness and timing shape gastruloid development, revealing uncoupling between polarization and transcriptional programs.

Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning

Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids

journals.biologists.com/dev/article/...

A human-specific regulatory mechanism revealed in a pre-implantation model Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia.
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...

Regulation of epithelial tissue homeostasis by active trans-epithelial transport Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...

Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...

How epithelial junctions mature: Study shows conformational transition in key protein Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof. Carsten Grashoff now provides insight into the molecular details underlying the ...

Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof Carsten Grashoff now provides insight into the molecular details underlying the formation of the connections between epithelial cells. #Biology

The complex microscopic dynamics of cells in high-density epithelial tissues Epithelial tissues line the surfaces of vital organs and are often densely packed in a disordered, mechanically arrested state, referred to as jammed or glassy state. While collective migration at low...

Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...

For #zebrafish people - we have a joint @ZDMSociety @InfoIzfs webinar focused on single-cell tech coming up on February 20th. Featuring Yinan Wan, Jialin Liu and Loic Royer. Register here: www.izfs.org/education/we...

Epithelial tension controls intestinal cell extrusion Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

Epithelial tension controls intestinal cell extrusion | Science www.science.org/doi/10.1126/...

Beautiful story that combined mechanobiology, evolution, and the power of fly (opto)genetics to make sense of the cephalic furrow. It was a pleasure writing the News & Views. No doubt this is still just the beginning for the field of mechano-evo-devo! Hats off to all involved

Tsai, T. Y. C., Garner, R. M., & Megason, S. G. (2022). Adhesion-based self-organization in tissue patterning. Annual review of cell and developmental biology, #EpithelialMechanicsReview www.annualreviews.org/content/jour...

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...

Always nice to see the field moving forward! Paper out from the White lab in @nature.com today! www.nature.com/articles/s41.... #Microtubules conferring #mechanical resistance to compression in melanoma cells > similar to our findings in @natcellbio.nature.com doi.org/10.1038/s415... ☝️

Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: marie-helene.verlhac@college-de-france.fr

We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter