Drew Sellers, PhD

Pace Picante Cattle Drive New York City YouTube video by 1071rednaj

@djjohnrichards.bsky.social …every time you thank a listener/donor from #NewYorkCity …my brain says #Moo York City?! 🫣🫤🤩

m.youtube.com/watch?v=OCJg...

I can vouch! …so painful, and you know “mods”/updates will follow—requiring MORE wasted time. (Sad)

Newsom and Trump agree on something: Blame Wall Street for the housing crisis Political foes Newsom and Trump are both targeting corporate landlords this week. Newsom plans to address the issue during Thursday’s State of the State.

quite sure @governor.ca.gov is just as surprised as I am to realize a shared sentiment…what is this #upsidedown #bizzaro reality in which i have just found myself?!??

calmatters.org/housing/2026...

…and the contrast. poetic.

@djjohnrichards.bsky.social doi g the morning #flex …only on KEXP #Range 🤯🤯

Safety and tolerability of intrarectal perfluorodecalin for enteral ventilation in a first-in-human trial This first-in-human, dose-escalation trial demonstrates that intrarectal administration of perfluorodecalin is safe and well tolerated in healthy volunteers, with no systemic absorption. These finding...

Poetic justice?? seems “blowing hot air up someone’s @$$” is actually be lifesaving. #ironic 🤯

www.cell.com/med/abstract...

@djjohnrichards.bsky.social …hitting the all the #feels , makes me weep every time.

Delivery of a fibrin-binding hemostatic polymer ameliorates neurovascular damage and neural tissue loss after traumatic brain injury 3D pathology shows that a fibrin-binding polymer increases neurovascular network and neural tissue sparing after TBI.

Excited to share this work. A tremendous collaboration with the Liu, Pun, and White labs! …perfect for perusing on #FluorescentFriday #Brains www.science.org/doi/10.1126/...

Screenshot of Linkedin profile viewers, with a visit from a viewer with the role of “Project Administrator in the Government Administration Industry”.

this doesn’t feel creepy (at all)—perfectly normal “check-in” in the #Orwellian dystopia of today. 😔

ooh, could i be included in the fun??! 🙏

@kexp.bsky.social did Morgan just say there is numerical #data to substantiate @djjohnrichards.bsky.social #7thbest day claims??

eRA is live for IAR, at least—-with a fun little time-crunch to complete reviews! (so we get to go through the exercise…and wait to see if awards are forthcoming)

In Situ Bioconjugation of Synthetic Peptides onto Universal Chimeric Antigen Receptor T Cells for Targeted Cancer Immunotherapies The recent development of modular universal chimeric antigen receptor (CAR) T-cell platforms that use bifunctional adaptor intermediates to redirect engineered T-cell effector function has greatly expanded the capabilities of adoptive T-cell therapy, enabling safer and more comprehensive cancer treatment. However, universal CAR receptor systems rely on unstable transient recognition of tag-coupled intermediates for T-cell activation, and the array of targeting intermediates has been limited to antibodies and small molecules. Addressing these shortcomings, we engineered universal CAR T-cell receptors that can be covalently modified with synthetic biomaterials in vivo by accelerated SpyCatcher003-SpyTag003 chemistry for cancer-cell targeting. SpyCatcher003-modified CARs, nicknamed DB5 CARs, displayed fast, low-nanomolar reaction kinetics with a synthetic αvβ6-binding peptide that incorporates a SpyTag003 peptide via branched peptide synthesis to comprise a bifunctional intermediate. Prearming DB5 CAR T cells or prelabeling target cells with the bifunctional peptide produced selective CD4+ and CD8+ CAR T-cell responses against αvβ6+ cancer cells in vitro. Furthermore, the synthetic targeting intermediate showed robust DB5 CAR T-cell arming in vivo and selectively reduced αvβ6+ tumor progression in a dual flank xenograft model. We demonstrate the versatility and therapeutic potential of “Cyborg” CAR T-cell therapies that utilize synthetic biomaterials to direct CAR T-cell activity via highly selective bioconjugation that occurs in vivo.

It's officially "Live"....Cyborg CAR T Cells. Our paper was published today in #ACSNano (stay tuned for actual "in press" date)... when one ventures on a “side-project” to target cell therapies to the #CNS. …LOTS of persistence by Ian Cardle, PhD. (some cussing too!)😂

urldefense.com/v3/__https:/...

As a reviewer of #GradSchoolApps … i wish mentors would remember when writing #LettersofRecommendation …the letter is about the student’s potential and how they have learned/accomplished research objectives/potential. Mentor’s “qualifiers for evaluation” r ONLY mentor years, n, and ranking %!

Jimmy Carter Palestine Peace Not Apartheid book cover.

an easy man to find #inspiring in the mission with which he seemed to live his life. #JimmyCarter #POTUS #39

My ode to when the #universe is conspiring… and a potential indicator of all the “fine thinking” #Musk will bring from #Tesla to #DOGE. #BuckleUp

leg lamp at a coffee shop

I am always a glutton for a little #sciencetalk over #coffee …and noticed this little treat on today’s adventure! #iykyk …you might even know the taste of a cold galvanized #metalpole

Post-cleave Peptide precipitation in Ether

Nothing quite like the #sinkingfeeling you get the moment you realize (a little too late) that you were going to do a #SideChain reaction on the new #Peptide 😩

⬆️ Updated ⬆️ Oligodendroglia starter pack!

If you are interested in Oligos, OPCs, myelin, and more check out these awesome folx and their cool findings!

Please share, nominate, and comment below to be added. Go team Oligo 🧠🦋!

go.bsky.app/JgL2evN

if there is room, i’d love to join!

Great starter pack for #stemcell biologists. 😊🩵🦋

go.bsky.app/UTW4d7b

would love to join, if there is room!

oops, was so tickled i forgot to “tag” @ardemp.bsky.social ! 💪🏻

solid ~flex~! 🤩🤓 …narry a #pun

(and i am surely not the first to take a swing at that pun!)

So, you’re saying “there’s a chance…”!

It’s still as cool as the first time I saw it! #LibertyBlue #peptide #synthesis — #science at night!

would love to join the fun!

Question for #cancer #flanktumor #model (ers)…if vascularization (CD31, green label) is poor, what are better alternatives for targeting experiments?

🤯 (🫣)

Room for one more?? 🤞🤞