We're thrilled to announce the Ctrl-Z Award, a US$2,500 prize for researchers “who discover substantial errors in their published work and take meaningful steps to correct the scientific record."
Covered by @nature.com today; read more here: centerforscientificintegrity.org/2026/03/10/a...
Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection
#gdTcells @cp-immunity.bsky.social
A study shows the consequences of poor Antibody Validation
- Out of 614 antibodies tested, 97 failed
- These 97 non-specific antibodies (43 proteins) were used in 640 publications
- 9443 mice and 5015 human samples wasted
Waste of animals, human samples, time, and trust
tinyurl.com/OGA-Ab
Antibodies don't work.
NLRP3 is by far the most studied inflammasome — yet <30% of commercial antibodies were specific.
Only 4 of 14 tested antibodies detected NLRP3 specifically.
Antibodies must be validated before use.
Full report by @ycharos.bsky.social : zenodo.org/records/1162...
Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements
onlinelibrary.wiley.com/doi/10.1002/...
Excited to share my paper published today in @cp-immunity.bsky.social! We find that when CTLs integrate antigen and cytokine signaling, the timing of these cues matters - shedding light on an old question: Why do NK cells sometimes behave like CD8+ T cells?
www.sciencedirect.com/science/arti...
I had the privilege to meet artist Mary Griffiths. Mary got inspired by Hi-C maps and over zooms we spoke about Hi-C maps, patterns and drawings. Mary’s Hi-C inspired art has been exhibited eg the Royal Academy. We wrote this piece about this art-science collaboration
pubs.aip.org/aip/bpr/arti...
'When we asked authors for the data, we have obtained it in less than 50% of the cases & often did not even receive a response. In addition, if repository numbers are included, the data in the repository is often classified as private and therefore not accessible.'
link.springer.com/article/10.1...
I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories!
link.springer.com/collections/...
Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ
BIG NEWS!
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!
Keynotes include:
Andrew McKenzie, Kazuyo Moro.
ilc6vancouver.com
#ILC6 #ILC6Vancouver #2026ILC6
(1/3)
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Happy to share new work from #theonlylabever, lead by the phenomenal @sltai.bsky.social - who developed a tool to study the biology of ILC3s, identifying their role in controlling CSF2-dependent myeloid cells. 🤗
@mucosalimmunol.bsky.social @societymucosalimm.bsky.social
OA: doi.org/10.1016/j.mu...
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
We are currently in the process of recruiting a technician. 🥼🐭🔬
If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!
STAT3 operates as an inflammation-dependent transcriptional switch https://www.biorxiv.org/content/10.1101/2025.09.26.678857v1
Dear friends,
As have become a habit, I mark each #autumnequinox by sharing a small poem by Xin Qiji. I also start my translation cycle of Chinese and Japanese poems and prose that mark the twenty-four lunisolar micro-seasons. Translation notes blogged here:
#everynightapoem
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
bioRxiv partners with Dryad to enable easier, better linking to curated datasets connect.biorxiv.org/news/2025/09...
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis doi.org/10.1038/s415...
IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity
Cell www.cell.com/cell/fulltex...
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
A screenshot of the old style '10 PM, do you know where your children are?' PSA poster, with the 'children are?' scribbled out and 'TCR germline gene reference comes from?' crudely pasted over the top.
I've got a PSA to the T cell receptor researchers of #immunosky to let you know about a new paper we've just got out: doi.org/10.1016/j.im...
This covers how our field is handling the sets of germline #TCR genes used in our research. Maybe not the most glamorous topic, but it’s kind of a big deal…
Targeting LAIR1-mediated immunosuppression adds a new weapon to our immunotherapy arsenal: buff.ly/aJxzdS4
Ezri P. Perrin, Hannah K. Dorando & Jacqueline E. Payton provide a Commentary on Tao et al. (buff.ly/uaGEIUb)
In his lecture on “The Generation and Modification of Lymphocyte Antigen Receptor Genes,” Eugene Oltz, @ohiostatemed.bsky.social, described how chromatin accessibility controls where V(D)J recombination occurs during immune cell development. #AAIcourses
Image credit: @gloglita.bsky.social @lifescienceeditors.bsky.social captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Transcription factors create accessibility through distinct mechanisms involving nucleosome sliding and eviction. A) Estimation of nucleosome-free (NFR) and nucleosomal fragment probabilities using ATAC-seq fragment size distributions. B) Example genomic locus showing ATAC insertion profile, nucleosome occupancy scores, and dyad positions inferred from NucleoATAC.
Liu et al., 2025. An automated ATAC-seq method reveals sequence determinants of transcription factor dose response in the open chromatin www.biorxiv.org/content/10.1...
▶️RoboATAC - automated ATAC-seq
▶️Deep learning models: motif orientation, spacing, flanking bases
▶️Nucleosome positioning analysis
