Cell Biology J-Club

Endosomal maturation is controlled by the trimeric Bulli-Mon1-Ccz1 GEF7 complex and Rab5-GTPase activating protein GAPsec www.biorxiv.org/content/10.6...

Distinct TRAPP complexes activate Ypt/Rab GTPases in secretion and autophagy The mechanism by which the conserved Ypt1/Rab1 GTPases mediate the beginning of two cellular processes, secretion and autophagy, is unknown. Gyurkovska et

Distinct TRAPP complexes activate Ypt/Rab GTPases in secretion and autophagy url: rupress.org/jcb/article-...

TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy - Nature Cell Biology Xu, Li, Deng and colleagues identify a ubiquitin-dependent degradation mechanism for cleaved GSDME mediated by TOLLIP through endocytosis and autophagy. They show this modulates pyroptosis, antitumour...

www.nature.com/articles/s41...

FLEXTAG: a small and self-renewable protein labeling system for anti-fading multi-color super-resolution imaging - Nature Communications FLEXTAG is a versatile, self-renewing protein labeling system that enables long-term, multi-color super-resolution fluorescence imaging of subcellular structures in live and fixed cells, with minimal ...

www.nature.com/articles/s41...

Revised : Reconstitution of multistep recruitment of ULK1 to membranes in autophagy www.biorxiv.org/content/10.1...

www.nature.com/articles/s41...

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2 The mechanistic target of rapamycin (mTOR) protein kinase forms two multiprotein complexes, mTORC1 and mTORC2, that function in distinct signaling pathways. mTORC1 is regulated by nutrients, and mTORC...

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2 | Science www.science.org/doi/10.1126/...

Sec23b regulates cell migration by orchestrating collagen I secretion and processing. www.biorxiv.org/content/10.6...

N6-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93 - Nature Cell Biology Lee et al. report a mechanism regulating mRNP export mediated by N6-adenosine methylation, METTL3 and NUP93 with potential implications for nephrotic syndrome and other human diseases.

www.nature.com/articles/s41...

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress Cryo–electron tomography reveals how mitochondria reorganize their translation and folding systems under proteostatic stress.

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress | Science Advances www.science.org/doi/10.1126/...

Myelin sheaths persist for weeks following axon degeneration Axon degeneration results in persistent, empty myelin sheaths and elicits unexpectedly rare phagocytic responses from microglia.

Myelin sheaths persist for weeks following axon degeneration | Science Advances www.science.org/doi/10.1126/...

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagatio...

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain: Cell www.cell.com/cell/fulltex...

www.biorxiv.org/content/10.6...

VAMP8 function reveals tight linkage between endocytic recycling and endocytosis

www.biorxiv.org/content/10.1...

VAMP8 function reveals tight linkage between endocytic recycling and endocytosis

www.nature.com/articles/s41...

Hierarchical membrane-chromatin tethering buffers nuclear envelope assembly against alterations in lipid flux www.biorxiv.org/content/10.6...

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

RNA-specific local translation is patterned by condensates for multinucleate cell growth
www.nature.com/articles/s41...

Optogenetic control of PLC-γ1 activity directs cell motility www.biorxiv.org/content/10.1...

The Golgi Network, Volume II This book explores the interaction of Golgi with different organelles such as ER, the vesicular system, and protein complexes that execute these tasks.

A wonderful collection of contemporary topics and perspectives on secretion and Golgi biology edited by Akihiko Nakano and Jaakko Saraste.
The Golgi Network, Volume II @SN and link.springer.com/book/10.1007...

www.nature.com/articles/s41...

NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling www.biorxiv.org/content/10.6...

Phenotypic CRISPR screens identify NLRX1 as an essential activator of the human mitochondrial permeability transition | PNAS www.pnas.org/doi/10.1073/...

Evolutionary remodeling of a remnant GET pathway factor into PEX38, an essential peroxin | PNAS www.pnas.org/doi/10.1073/...

Hoi1 targets BLTP2 to ER–PM contact sites to regulate lipid homeostasis Bridge-like lipid transfer proteins transport lipids at membrane contact sites, but how they are targeted to these sites is not well understood. Dziurdzik,

Hoi1 targets BLTP2 to ER–PM contact sites to regulate lipid homeostasis url: rupress.org/jcb/article-...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1
www.nature.com/articles/s41...

In @eLife.bsky.social: Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons doi.org/10.7554/eLif...

Class-I myosin responds to changes in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells | PNAS www.pnas.org/doi/10.1073/...

STARD3 regulates lysosome positioning and contacts via a GSK3-controlled phosphorylation switch - The EMBO Journal Membrane contact sites (MCS) are dynamic regions where the membranes of two organelles come into close apposition. MCSs play many roles in cellular homeostasis by facilitating inter-organelle lipid ex...

link.springer.com/article/10.1...

PML targets and resolves structured protein inclusions to mitigate neurodegeneration - Nature Cell Biology Wang et al. show that promyelocytic leukaemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML i...

www.nature.com/articles/s41...

www.nature.com/articles/s41...