Vaughn Smider, MD, PhD's Avatar

Vaughn Smider, MD, PhD

@vvsmider

Biomedical researcher, antibody investigator (especially cow antibodies ๐Ÿฎ, which are the best), drug discoverer, entrepreneur ๐Ÿ‡บ๐Ÿ‡ธ ๐Ÿ‡บ๐Ÿ‡ฆ Founder and President at Applied Biomedical Science Institute: https://absinstitute.org

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25.11.2024
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Latest posts by Vaughn Smider, MD, PhD @vvsmider

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Her work paved the way for blockbuster obesity drugs. Now, sheโ€™s fighting for recognition Svetlana Mojsov helped discover the hormone GLP-1. Why has she been excluded from its history?

Svetlana Mojsovโ€™s research paved the way for Ozempic, but she had to fight for her seat at the table. The Matilda Effect strikes again! ๐Ÿ˜ค

This #WomensHistoryMonth, we begin by honoring the chemist who identified the active GLP-1 hormone.

Itโ€™s high time we credit the women who change the world. ๐Ÿงชโœจ

06.03.2026 03:32 ๐Ÿ‘ 270 ๐Ÿ” 66 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1

And the science really isnโ€™t โ€œintriguingโ€ at allโ€ฆ

05.03.2026 18:03 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

This happens in science all the time- a little nugget of interesting data, filed away, that can re-emerge later in another context.

05.03.2026 18:02 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

โ€œit is time, finally and forever, to get rid of for-profit scientific publishers.โ€

04.03.2026 08:00 ๐Ÿ‘ 2 ๐Ÿ” 3 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Do America's Top Health Research Officials Stick Around Too Long? Critics argue that NIH directors should have term limits. Others say leadership continuity matters. Who's right?

Interesting story (and beautiful graphic) from Undark about how long NIH institute directors stay (and should stay) in their positions.

undark.org/2026/03/04/t...

04.03.2026 21:19 ๐Ÿ‘ 17 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

โ€œit is time, finally and forever, to get rid of for-profit scientific publishers.โ€

04.03.2026 08:00 ๐Ÿ‘ 2 ๐Ÿ” 3 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
An announcement that the Senate voted to reauthroize the SBIR/STTR program.

An announcement that the Senate voted to reauthroize the SBIR/STTR program.

The Senate has (finally) voted to reauthorize the small business SBIR/STTR program.

Not reauthorized yet, but this was likely the biggest hurdle.

04.03.2026 01:55 ๐Ÿ‘ 96 ๐Ÿ” 27 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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Meet three scientists who said no to Epstein The warning signs included a web search, a motherโ€™s doubts, and inklings of a โ€œsexist attitudeโ€

This is a nice contrast to all the awful behavior confirmed through the Epstein files. Proud of @jenlucpiquant.bsky.social & @seanmcarroll.bsky.social for picking up on the sexism & charlatanism right away.

03.03.2026 15:29 ๐Ÿ‘ 440 ๐Ÿ” 145 ๐Ÿ’ฌ 8 ๐Ÿ“Œ 16
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Ivermectin is making a post-pandemic comeback, among cancer patients The anti-parasitic drug became a household name during the COVID-19 pandemic, and it is now being embraced as an alternative treatment for cancer. It is as politically polarizing as ever.

The mass psychosis over Ivermectin as a "cure all" miracle drug did not end w COVID. It's being embraced as a cure for cancer in right wing circles.
If you have scabies or a parasitic worm infection it ivermectin helps.
It is NOT effective chemotherapy for any cancer!
www.npr.org/2026/03/02/n...

03.03.2026 21:07 ๐Ÿ‘ 72 ๐Ÿ” 12 ๐Ÿ’ฌ 12 ๐Ÿ“Œ 3

Just had a meeting with another colleague who is leaving the United States for Canada because of the political and science climate here.

This is just devastating for science in America, but I totally understand.

02.03.2026 20:55 ๐Ÿ‘ 23 ๐Ÿ” 4 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Some shit is about to go down with NIH study sections, friends. Keep your eyes peeled for change that may affect your grant submissions.

03.03.2026 02:30 ๐Ÿ‘ 80 ๐Ÿ” 39 ๐Ÿ’ฌ 7 ๐Ÿ“Œ 7

bsky.app/profile/tiva...

03.03.2026 01:49 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Science and Engineering is the basis of modern civilization, but particularly those studies into fundamental things. It is a foundational building block from which most wealth eventually derives. When we sacrifice it, we sacrifice much of our future.

01.03.2026 19:47 ๐Ÿ‘ 6 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Ultra-sensitive CAR T cells eliminate hard-to-treat tumours in mice Nature - A proof-of-concept study opens up an avenue for treating solid tumours that express low levels of a target antigen.

Ultra-sensitive CAR T cells eliminate hard-to-treat tumours in mice

A proof-of-concept study opens up an avenue for treating solid tumours that express low levels of a target antigen.

www.nature.com/artic...
1/3

01.03.2026 21:39 ๐Ÿ‘ 28 ๐Ÿ” 10 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Given that clonal biofilms of single bacterial species rapidly diversify into niche specialists, how do biofilms of multiple species evolve?
A ๐Ÿงต featuring new collaborative pubs:
1. www.biorxiv.org/content/10.6...
2. www.nature.com/articles/s41...

01.03.2026 18:53 ๐Ÿ‘ 47 ๐Ÿ” 19 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Ohh.... #biology #lego

01.03.2026 17:57 ๐Ÿ‘ 125 ๐Ÿ” 40 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 2
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That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

01.03.2026 15:32 ๐Ÿ‘ 1541 ๐Ÿ” 436 ๐Ÿ’ฌ 40 ๐Ÿ“Œ 22

So Iโ€™d imagine that Iโ€™m not the only one looking into switching my (low level) paid account from open.ai to Anthropic. Any thoughts about which performs better for your average academic scientist?

28.02.2026 20:23 ๐Ÿ‘ 5 ๐Ÿ” 1 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

Every now and then I read a paper that opens my eyes to see an aspect of biology in a new way. This paper blew my mind - TLR7/8 have agonist sites to bind viral RNA, and antagonist sites to bind endogenous RNA degrad. products, enabling self/nonself discrimination: www.nature.com/articles/s41...

28.02.2026 20:48 ๐Ÿ‘ 5 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1

Rare disease day. I have chordoma, a one in a million cancer. 300 new cases a year. My husband died of neuroendocrine cancer, 10,000 new cases a year.

i note the steep cuts to the National Cancer Institute budget.

28.02.2026 22:10 ๐Ÿ‘ 20 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Very sad news. David Botstein made enormous contributions to molecular biology & genetics. I first met him in a grad school interview. I learned something from him each of the few times I saw him since. Indelible personality. Here he is giving a keynote at the 2015 UCSD Genetics Retreat.

28.02.2026 20:35 ๐Ÿ‘ 24 ๐Ÿ” 7 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 1
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Today, 1 in 10 Americans lives with a rare disease. Most of the 7,000+ identified worldwide still have no approved treatment.

Last year, @scripps.edu added its 18th FDA-approved medicine for one of these conditionsโ€”advancing options for patients with few alternatives. #RareDiseaseDay

28.02.2026 18:54 ๐Ÿ‘ 10 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
A 1 y/o yellow Labrador retriever

A 1 y/o yellow Labrador retriever

Another Maisie - 1 y/o yellow lab
Bday last week

28.02.2026 18:56 ๐Ÿ‘ 8 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Today is #RareDiseaseDay

Through EB Research Partnership, families, scientists, and supporters are pushing research forward, pioneering progress in EB and helping reshape whatโ€™s possible for rare diseases.

Itโ€™s not a matter of if.
Itโ€™s a matter of time.

๐Ÿฆ‹ Learn more: ebresearch.org

28.02.2026 17:00 ๐Ÿ‘ 3986 ๐Ÿ” 1010 ๐Ÿ’ฌ 83 ๐Ÿ“Œ 37
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Immunotherapy uses invisibility cloak to deliver direct hit to prostate cancer Immunotherapy uses invisibility cloak to deliver direct hit to prostate cancer

These โ€œcloakedโ€ or โ€œmaskedโ€ antibody-based drugs are a clever way to reduce side effects. They are activated in the tumor but inert in the blood, sort of like a pro-drug. More positive results for these types of molecules for prostate #cancer.

www.icr.ac.uk/about-us/icr...

28.02.2026 17:04 ๐Ÿ‘ 7 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Immunotherapy uses invisibility cloak to deliver direct hit to prostate cancer Immunotherapy uses invisibility cloak to deliver direct hit to prostate cancer

Hi Ian, we're so pleased that your cancer has been in remission for such a long time.

Hopefully you're interested in our article about the trial โคต๏ธ

www.icr.ac.uk/about-us/icr...

28.02.2026 15:51 ๐Ÿ‘ 11 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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The NIH Restructuring Congress Rejected Is Happening Anyway (I used Gemini Nano Banana 2 to create this fictional image.)

elizabethginexi.substack.com/p/the-nih-re...

27.02.2026 23:17 ๐Ÿ‘ 18 ๐Ÿ” 10 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1

Bear with me if you can as I attempt to use HPV vaccines to demonstrate why many canโ€™t see the danger of RFK Jr.

TLDR: Disease prevention takes time and discipline. Not discipline of an individual, but the ability to invest in public health when the benefits may not be immediately clear.

27.02.2026 15:38 ๐Ÿ‘ 484 ๐Ÿ” 204 ๐Ÿ’ฌ 10 ๐Ÿ“Œ 17
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Federal funding for US biomedical research is moribund.

Since October 1 2025, NIH is -80% in new grants and -70% in values (total dollars).

Labs are closing down and researchers are leaving science.

To what end?

26.02.2026 15:48 ๐Ÿ‘ 69 ๐Ÿ” 57 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 12
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We just interviewed Dr. Jay Bhattacharya on his vision for NIH, his new job at the CDC, on funding, on DEI and more. Available now: podcasts.apple.com/us/podcast/w...

26.02.2026 17:18 ๐Ÿ‘ 10 ๐Ÿ” 2 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 2