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Marina Khan

@marina-khan

Therapeutic Radiographer (RTT) R&D Lead Radiotherapy SABR Consortium committee member Views are my own

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16.11.2024
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Latest posts by Marina Khan @marina-khan

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#ESTRO consensus guidelines on #GTV delineation and dose-escalation in #rectalcancer, published in ctRO, Clinical and Translational Radiation Oncology.
πŸ‘‰ bit.ly/4cnC4me #openaccess
#radiotherapy #radiationoncology #guideline

03.03.2026 08:53 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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ALK+ #lungcancer often means staying on a TKI for years. If radiotherapy is needed for brain metastases or a growing spot, the big question is whether to continue the drug.

New ESMO–ESTRO guidance says combining them can increase side effects. #LCSM

www.sciencedirect.com/science/arti...

01.03.2026 19:20 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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NOTABLE ARTICLE, January 2026 #MedicalPhysics: A generalizable dose prediction model for automatic radiotherapy planning based on physics‐informed priors and large‐kernel convolutions
https://aapm.onlinelibrary.wiley.com/doi/10.1002/mp.70272

Please join us in congratulating Tianyu Xiong et al

01.03.2026 22:00 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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At #BTOG26, consultants will host a Career Development Session for Trainees - An informal session for trainees of any grade interested in a career in thoracic oncology: Ask questions and chat to consultants from different specialties, all experienced in mentoring and career advice.
Sanjay Popat

19.02.2026 20:00 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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On World Cancer Day, we honor everyone who’s been touched by cancer.

We’re announcing a new traveling museum exhibition, The Journey to End Cancer: From Cause to Cure, presented by MD Anderson.

Join us on the journey to end cancer. spr.ly/63327hynKT #OncSky #EndCancer

04.02.2026 13:12 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Why does funding for clinical research matter?

Because #ClinicalTrials depend on sustained investment to advance cancer treatment and provide better outcomes for patients.

πŸ‘‰ Like and reshare this message to highlight why cancer research matters.

#WorldCancerDay #EORTCimpact #CancerResearch

30.01.2026 11:04 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Blue text graphic with black and white text which reads: 'Thousands more men in England offered abiraterone, one of our prostate cancer breakthroughs'

Blue text graphic with black and white text which reads: 'Thousands more men in England offered abiraterone, one of our prostate cancer breakthroughs'

We’re pleased that abiraterone can now be offered to thousands more men affected by prostate cancer. Read more about this decision and what it means: cruk.ink/3LzxTbS

17.01.2026 14:34 πŸ‘ 11 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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An ESTRO-EPTN Delphi consensus on robustness evaluation in proton therapy Proton therapy (PT) has emerged as a promising modality in radiotherapy, offering superior dose conformity compared to conventional X-ray radiotherapy due to the unique physical properties of protons,...

An ESTRO-EPTN Delphi consensus on robustness evaluation in proton therapy, just published in PhiRO - Physics and Imaging in Radiation Oncology.
πŸ‘‰ bit.ly/3Ydzyql

30.12.2025 14:13 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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πŸ“£ ESTRO 2026 Pre-Meeting Webinars
Get ready for #ESTRO26 with two online pre-meeting webinars ahead of the congress in Stockholm (15–19 May 2026).
Cases will be discussed β€” we can’t wait to engage with you!
πŸ”— Info & registration: bit.ly/4pAM9PH
#PMCwebinars #ESTRO26

30.12.2025 16:22 πŸ‘ 3 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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As part of the World Cancer Day 2026 campaign, IPOS is hosting an insightful webinar to spotlight the key findings from the recently published Lancet Oncology Commission report, β€œThe Human Crisis in Cancer.”

Free for everyone ipos-society.org/event-6480465

16.12.2025 21:07 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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πŸ“’ Join the ESTRO course in Rome to boost your skills in SRS/SRT for brain metastases & skull base lesions!

πŸ“… 26–28 March 2026
⏰ Early deadline: 7 Jan 2026
πŸ‘¨β€πŸ« Course Director: Maximilian Niyazi
πŸ”— Register: bit.ly/44BetJJ
#ESTROSchool26 #SRS #SRT #Radiotherapy

01.12.2025 16:19 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Effectiveness of Chemotherapy Plus Immunotherapy and Molecular Alterations in Advanced Biliary Tract Cancer: Real-World Evidence From a Single-Center Australian Cohort
@cancer-control.bsky.social
@journals.sagepub.com
journals.sagepub.com/doi/10.1177/...
#carcinoma #biomarkers #oncology #prognosis

21.11.2025 19:09 πŸ‘ 2 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
NPCA State of the Nation Report 2025 - National Cancer Audit Collaborating Centre The aim of the National Prostate Cancer Audit (NPCA) is to evaluate the patterns of care and outcomes for patients with prostate cancer in England and Wales, and to support services to improve the qua...

πŸ“’ The NPCA State of the Nation Report 2025 is OUT!

Find the report, supplementary documents & provider results here www.natcan.org.uk/reports/npca...

@natcan-news.bsky.social @hqip.bsky.social @prostatecanceruk.bsky.social @alison-tree.bsky.social @nhsengland.bsky.social

Please share!

09.10.2025 09:58 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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πŸ—£οΈ New #ESTROWebinar! Management of SCLC in the Immunotherapy Era
πŸ—“ 5 Nov | 17:00–18:00 CET
Chaired by Prof Corinne Faivre-Finn & Dr Suraiya Dubash (UK)
πŸ’» Live Q&A with experts!
More info & Registration here: πŸ‘‰ bit.ly/3KAbjPB

#RadiationOncology #LungCancer #SCLC #Immunotherapy #Webinar

10.10.2025 10:09 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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πŸ“’ The first-ever ESTRO Clinical Workshop is coming to Vienna | 12–13 Mar 2026! Spots are limitedβ€”don’t miss out.
πŸ“Œ Submit your motivational statement by 22 Oct to secure your place.

πŸ’» Apply now πŸ‘‰ bit.ly/47wlj5G
#ESTROCLIN26 #ClinicalWorkshop #RadiationOncology

10.10.2025 10:25 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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πŸ’‘ Discover the latest in mutation-driven lung cancer research.
Session 4 with @ruthstraussfdn.bsky.social rings science, debate, and progress together.
πŸ“… 13 Nov | πŸ“ The View, London
πŸ”— www.btog.org/non-smo...
#LungCancer #LCSM #NonSmokingLungCancer

09.10.2025 09:00 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Calling all Young and Early Career Cancer Nurses (YECCN)

The YECCN MIG is currently looking for 1x MIG Chair, 1x secretary and 8x committee members.

If interested & under 35/working for <5yrs, please email by 5th October, a 300 word expression of interest to:

ukons@media1productions.co.uk

#YECCN

28.09.2025 00:04 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Exciting news! We’ve launched ASCO Edge, an online oncology practice management educational series exclusively available to ASCO members.

Get started today: brnw.ch/21wVVu3

19.09.2025 17:19 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Say no to new PFI in our NHS - take action The government’s new 10-Year Plan for Health is proposing to bring disastrous private finance deals back into our NHS.

Please check out this from We Own It.

weownit.org.uk/act-now/new-...

19.09.2025 21:10 πŸ‘ 4 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Drew Moghanaki and Gerry Hanna Discuss Survival and Toxicity of New Phase 3 Trial in LS-SCLC - OncoDaily Drew Moghanaki and Gerry Hanna Discuss Survival and Toxicity of New Phase 3 Trial in LS-SCLC / cancer, Drew Moghanaki, Gerry Hanna, LS-SCLC, OncoDaily, Oncology

Drew Moghanaki and Gerry Hanna Discuss Survival and Toxicity of New Phase 3 Trial in LS-SCLC

@drewmoghanaki.bsky.social @gerryhanna.bsky.social

oncodaily.com/voices/drew-...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #SCLC #LungCancer

11.09.2025 17:55 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Quality assurance in the randomized multicentre phase III trial EORTC-1709-BTG/CCTG CE.8 (MIRAGE) for glioblastoma: Results of the #radiotherapy delineation benchmark case procedure, published in the Green Journal.
πŸ‘‰ Read it before your patients: bit.ly/4fLoatJ

12.09.2025 07:44 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Postcode lottery for new cancer treatments, doctors warn Experts say bureaucracy is

New #radiotherapy innovations are being stifled by the tortuous commissioning process. Patients deserve better! #radonc #oncology #medtwitter
Postcode lottery for new cancer treatments, doctors warn - BBC News www.bbc.co.uk/news/article...

11.09.2025 07:55 πŸ‘ 11 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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πŸ“’ Attending #EAPM2025 this week?
Today, our @eortc.org #QualityofLife Group member Ines Rathgeber will report on the development of an e-learning course focusing on the use of EORTC PRO measures for quality of life assessment in clinical practice πŸ‘‡

eapm.eu.com/2025-eapm-co...

#CancerResearch

11.09.2025 09:05 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Living With You may be undergoing maintenance treatment or you may have completed treatment but you are still part of the pancreatic cancer community.

βœ… Finished treatment or on maintenance for #PancreaticCancer? We’ve got resources to help.

Find tips on managing side effects, eating well, coping with scanxiety, and staying up to date on the latest research. https://bit.ly/4lX0owd #GuideToAction #LetsWinPC

04.09.2025 16:00 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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One Voice for Radiotherapy: Creating World Radiotherapy Awareness Day - OncoDaily One Voice for Radiotherapy: Creating World Radiotherapy Awareness Day / cancer, Katie Wakeham, OncoDaily, Oncology, One Voice For Radiotherapy, radiation

One Voice for Radiotherapy: Creating World Radiotherapy Awareness Day

oncodaily.com/insight/one-...

#Cancer #Oncology #OncoDaily #Health #Medicine

10.08.2025 18:09 πŸ‘ 9 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Putting patients first: Transforming cancer diagnosis, treatment and care through patient-centred approaches Delivering high quality care is at the forefront of the cancer agenda for professionals and policy makers alike. Whilst it is clear that drug development alongside technical innovations and advancemen...

Putting Patients First: Transforming Cancer Diagnosis, Treatment and Care Through Patient-Centred Approaches.

In this guest editorial, we reflect on why meaningful progress & the delivery of high quality cancer care requires more than technical innovation

www.radiographyonline.com/article/S107...

01.08.2025 06:23 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
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Today on #WorldLungCancerDay, we reaffirm our mission to support thoracic oncology professionals and advocate for equitable, world-class care for all patients.

Together, we strive to match the best survival rates globally. πŸ’™
#WLCD2025 #LungCancerAwareness #LCSM #lungcancer

01.08.2025 08:09 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear.
Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population.
Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies. 
Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.

Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear. Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population. Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies. Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.

🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo...
Short walkthrough below. Let’s dive in! 🧡 (1/9)
#GBM, #BrainTumor

17.07.2025 09:07 πŸ‘ 13 πŸ” 6 πŸ’¬ 2 πŸ“Œ 1
Breaking news - Breast Cancer Breakthrough! #breastcancer
Breaking news - Breast Cancer Breakthrough! #breastcancer YouTube video by Dr Liz O'Riordan

BREAKING NEWS

Scientists at the @icr-ctsu.bsky.social have discovered how to predict which ER+ HER2+ cancers have a higher risk of recurrence in just 2 weeks!

Breaking news - Breast Cancer Breakthrough! #breastcancer
youtube.com/shorts/3rYUU...

19.07.2025 08:23 πŸ‘ 44 πŸ” 12 πŸ’¬ 3 πŸ“Œ 0