Eduardo Villablanca

#ECCO26 Feb 19 Stockholm, Ludwig Erlmeier (UMCG) presents: “High-throughput antibody epitope repertoire profiling links NOD2 risk-variants to specific antibody responses in Crohn’s disease.”
A step toward connecting genetic risk with functional immune signatures in IBD
cm.ecco-ibd.eu/cmPortal/sea...

Promoting healing to cure intestinal autoimmunity | Knut and Alice Wallenberg Foundation Immunosuppressive drugs are currently the main therapeutic option for treating inflammatory bowel disease (IBD). However, fewer than half of patients achieve sustained benefit, and these treatments ca...

Our KAW research grant focuses on uncovering novel drivers of mucosal healing by leveraging unique IBD cohorts and novel technologies to map cell–microbiota interactions, complemented by advanced non-animal models like human organoids

Check the note 👇🏼

kaw.wallenberg.org/en/research/... #Hashtag

Spatial omics at the forefront: emerging technologies, analytical innovations, and clinical applications Liu et al. review how spatial omics technologies reveal the organization, interaction, and evolution of tumor cells and their microenvironment within tissues. They highlight analytical advances that t...

Spatial omics at the forefront: emerging technologies, analytical innovations, and clinical applications

@cp-cancercell.bsky.social

www.cell.com/cancer-cell/...

I thought science hinged on prestige. Moving abroad made me reassess my priorities In Denmark, this Ph.D. student fell in love with an egalitarian society that values work-life balance

This one resonates a lot!

“I thought science hinged on prestige. Moving abroad made me reassess my priorities”

www.science.org/content/arti...

Connecting AI to biology: Model Context Protocol Julio Saez-Rodriguez discusses how MCP servers are helping AI connect to life science databases, making AI a more reproducible tool for research.

Connecting AI to biology: Model Context Protocol
www.ebi.ac.uk/about/news/p...

Gut microbiota promotes immune tolerance at the maternal-fetal interface Microbiota-dependent tryptophan-derived indole deficiency is linked to mouse fetal resorption and human recurrent miscarriage. Tryptophan-derived indoles prime MDSCs and RORγt+ Tregs to suppress IFN-γ...

Gut microbiota promotes immune tolerance at the maternal-fetal interface

www.cell.com/cell/abstrac...

“our findings identify microbiota-dependent immune tolerance mechanisms that promote fetal development.”

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast (apCAF) populations across multiple cancer types. Mesothelial-related apCAFs locate near cancer cells while fibrocyte-...

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches: Cancer Cell www.cell.com/cancer-cell/...

Human gut M cells resemble dendritic cells and present gluten antigen - Nature An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune syst...

Human gut M cells resemble dendritic cells and present gluten antigen

@nature.com

www.nature.com/articles/s41...

The dawn of ‘off-the-shelf’ B cell-depleting therapies for autoimmune diseases - Nature Reviews Rheumatology In 2025, a new wave of ‘off-the-shelf’ B cell-depleting modalities for the treatment of autoimmune diseases emerged, encompassing allogeneic cellular therapies, in vivo chimeric antigen receptor engin...

The dawn of ‘off-the-shelf’ B cell-depleting therapies for autoimmune diseases

@Nature Reviews Rheumatology

www.nature.com/articles/s41...

Join us ag the upcoming DDLS CMB Conference:

Data Driven Systems Biology – Harnessing Big Data and Systems Approaches to Decode Complex Biology

March 24–25 at LifeCity, Hagastaden, Solna.

#scilifelab #DDLS #datadriven #systemsbiology

Register here! 👇🏼👇👇🏾👇🏿

lnkd.in/dT9gCvEu

Credits to @orlandorosss.bsky.social for the pic during my talk :) thanks!

What a great #BSI25! The second-largest immunology conference was a fantastic chance to meet old friends and make new ones. Amazing science, and they definitely know how to party 😜

#BSI25 day 2! Another wonderful day of immunology and a chance to discuss my PhD research during the first poster session. Meeting so many people, discussing cutting-edge immunology and sharing our passions for science! @mrccmm.bsky.social

Doctoral (PhD) Position – Spatial Transcriptomics, Bioinformatics & Mucosal Immunology

📍 Karolinska Institutet, Sweden

🗓️ Deadline: Dec 10, 2025

kidoktorand.varbi.com/what:job/job...

#SpatialTranscriptomics #Bioinformatics #MucosalImmunology
#SingleCellOmics #IBDResearch
#SystemsImmunology

Tattoo ink induces inflammation in the draining lymph node and alters the immune response to vaccination

PNAS www.pnas.org/doi/10.1073/...

An illustrated diagram of intestinal mucosal mast cells, cysteinyl leukotrienes, and food-induced (oral) anaphylaxis.

Joshua A. Boyce, MD, describes two studies implicating intestinally generated cysteinyl leukotrienes in food anaphylaxis. Learn more: nej.md/4rp7MEL

#MedSky #PedSky #Immunology

IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy Cytokines optimize and fine-tune effector T cell responses. Here, Jiang et al. utilize IL-9, with scarce receptor expression in normal tissues, to boost IL-9R engineered T cells for cancer therapy. IL...

IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy

Immunity www.cell.com/immunity/ful...

Lab manager inom immunologi och spatiell biolog | Eduardo Villablanca Open position not only to work in my lab but also the Engblom lab!!👇🏼👇🏾👇👇🏿 “Lab manager in immunology and spatial biology” Come join the Engblom and Villablanca labs! A lab manager position is avail...

🥷“Lab manager in immunology and spatial biology”

Open position not only to work in my lab but also the Engblom lab!!👇🏼👇🏾👇👇🏿

Join us!

www.linkedin.com/posts/eduard...

A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights Oral microbiome shows rising importance in human health. Cha et al. present the human reference oral microbiome (HROM), comprising 72,641 high-quality genomes from 3,426 species, including 2,019 previ...

42 ectopic oral species found in the gut could be predictive of systemic diseases 😲

A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights

Cell Host & Microbe www.cell.com/cell-host-mi...

Researchers link ultraprocessed foods to precancerous polyps — Harvard Gazette | Harvard University Colorectal cancer diagnoses have become increasingly common in adults 50 or younger in recent years, particularly in high-income countries like the U.S. A new study led by Harvard and Mass General Bri...

“Women who consumed the highest amounts of ultraprocessed foods — 10 servings per day on average — had a 45 percent higher risk of developing conventional adenomas, compared with those who consumed the lowest amounts”

www.linkedin.com/posts/harvar...

Call for SciLifeLab and DDLS Fellows 2025 Karolinska Institutet is recruiting three Assistant Professors in two programs tied to SciLifeLab. SciLifeLab and DDLS Fellows (Assistant Professors) are six-year positions with generous recruitment p...

Karolinska Institutet is recruiting three Assistant Professors through the @SciLifeLab and @DDLS programs!

These six-year positions come with generous support packages and a strong research environment.

Apply by Nov 15, 2025

#academiajobs #sciencelife #KI #SciLifeLab

news.ki.se/call-for-sci...

Packed room for @reinacampos.bsky.social’s talk at @cmm @ki.se!

Miguel presented stunning insights into how spatial cues instruct T cells in tissue barriers. Cutting-edge and deeply inspiring research!

CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success CD8+ T cells preferentially engage tumor cells in pockets termed CRATERs, which are rich with antigen presentation molecules and breach into the tumor mass from the stromal compartment. CRATERs expand...

Using Zebrafish to study CD8 T cells and tumors interactions in vivi the Zon lab identified “CRATER tumor niches”.

CRATER facilitate CD8+ T cell engagement and correspond with immunotherapy success

Cell www.cell.com/cell/fulltex...

Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance Cancer cells exploit distant tissues and organs to escape immune surveillance by activating nociceptive neurons, which remodel tumor-draining lymph nodes into an immune-suppressed state. Blocking this...

Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance

Cell www.cell.com/cell/fulltex...

Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest Galeano Niño et al. show that extracellular bacteria dominate colorectal and oral tumor microniches, remodeling the microenvironment with reduced cell density, scattered epithelium, and low proliferat...

Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest: Cancer Cell www.cell.com/cancer-cell/...

B cells in inflammatory bowel disease Inflammatory bowel diseases (IBD) have traditionally been considered T cell-driven disorders; however, accumulating evidence challenges this view and …

Great reference to get up to speed on B cells in IBD from our good friend @ejvillablanca.bsky.social
TL;DR B cells aren’t just bystanders in IBD, they’re active players in both gut protection, pathology and mucosal healing.
doi.org/10.1016/j.im... 🧪

Yesterday marked my installation as Professor at Karolinska Institutet

I’m extremely grateful to my family, friends, and lab members who joined to celebrate this milestone.

Excited for the journey ahead!

@ki.se

Saddened to hear of Sir John Gurdon’s passing at 92. His pioneering work in nuclear reprogramming laid the foundation for modern stem cell biology. A true giant of developmental biology and an inspiration to generations.

Nobel Laureate (2012, with Shinya Yamanaka).

👇🏼being grilled by him :)

Thanks @societymucosalimm.bsky.social for highlighting our work!

Kudos to Francisca and Bianca for an amazing job!

This is how we experience the Nobel Prize announcement every year, with excitement!

This year was extra special, as we celebrated the immunology and Treg!

👇🏼 Listening to our department prefect and lab neighbor, Marie Wahren, beautifully explaining the motivation behind this year’s #nobelprize