Jens Puschhof

The #iHOME2025 conference is off to a great start at @dkfz.bsky.social! We're excited for 2 days of organoid science from our speakers, like Barbara Treutlein, Max Reichert, Joep Beumer and @kimbakjensen.bsky.social. With @jackstadt-lab.bsky.social @moritzmall.bsky.social @kimboonekamp.bsky.social

organized with: @moritzmall.bsky.social, Rene @jackstadt-lab.bsky.social and Kim Boonekamp!

Just 2 days left to secure one of the last 5 spots for the “International Heidelberg #Organoid Meeting (#iHOME2025)” (20+21 March 2025) at @dkfz.bsky.social , powered by @proteintech.bsky.social, Cenibra, OLS @hlsalliance.bsky.social: indico.dkfz.de/event/1249/

🎉Congratulations to our Poster Prize winners, Manuel Mastel (DKFZ), Bianca Diaz (Weill Cornell Medicine), Martina Farber (NKI) & Menno Boon (NKI)!🎉 #AMC25
@manuelmastel.bsky.social @martina-farber.bsky.social @juliensage.bsky.social

#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology

Join the International Heidelberg Organoid Meeting 2025 🧠🫀🫁🔬March 20-21 @ Marsilius-Kolleg #Heidelberg! With exciting keynotes and abstract-selected posters & talks, iHOME will cover #cancer #organoid research from basic to clinical. Limited spots; register now: indico.dkfz.de/event/1249/

One of the great #postdoc opportunities through @hlsalliance.bsky.social at Michael Zimmermann's lab @embl.org and @emil-dkfz.bsky.social at @dkfz.bsky.social
🔬🧪🥽Apply till March 28, 2025!
Details here: hlsa.fra1.cdn.digitaloceanspaces.com/live/Postdoc...

Zimmermann Lab is now on BlueSky!

We are #microbiome #research lab @embl.org using high-throughput MS, bacterial genetics, gnotobiology & computational models to study metabolic interactions in #microbial ecosystems 🦠 🧫

Follow to learn more about our work, publications & job openings! #science

We have one postdoc position open with the Alliance Interinstitutional Postdoc Program.

🎈Details and applications here: 👇
health-life-sciences.de/opportunitie...
🎈Deadline: March 28, 2025, 5 pm CET.
🎈Project #128

Looking for a #postdoc position at the intersection of #cancer and the #microbiome?
Join Michael Zimmermann's lab at @embl.org and @emil-dkfz.bsky.social at @dkfz.bsky.social with a @hlsalliance.bsky.social #fellowship!

Details and Application: lnkd.in/e7heUKg2 (project #128, by 28th March)!

I've never been more excited to be (a very minor) part of a collaboration than this tour-de-force by the Elinav labs at @dkfz.bsky.social and WIS. Groundbreaking approach to figure out where the proteins in stool come from. Congrats Rafael Valdes-Mas, Avner Leshem, Danping Zheng! t.co/hKHkS6VGWS

Love the impactful translational work you're building!!!

TROPHIT1—a randomized, open-label, multicenter, phase II/III trial of sacituzumab govitecan compared to standard of care in metastatic colorectal cancer patients Colorectal cancer (CRC) ranks among the most common malignancies worldwide. Response rates to standard-of-care (SOC) treatment drop sharply beyond the…

🚨 We’re excited to announce a clinical trial targeting #TROP2 in advanced #colorectal #cancer. Learn more about it: @dkfz.bsky.social
www.sciencedirect.com/science/arti...

Wonderful kick off of our #CANBIO2 retreat with amazing talks by Sabine Tejpar, Jorge Moscat, María T. Diaz-Meco, @jenspuschhof.bsky.social and Thomas Helleday. What a great way to start in a new institute! 🤩
#newPI #scienceisfun #cancer_biology

Our new #organoid #organchip #coculture review. Congrats @kamilmoskal.bsky.social, Yeseul Lee, Luisa Siegert, Nimisha Khurana from @emil-dkfz.bsky.social @dkfz.bsky.social!
Cool experience connecting the dots between in organotypic models and microbiome with @hansclevers.bsky.social and Eran Elinav

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms The biology of cancer is characterized by an intricate interplay of cells originating not only from the tumor mass, but also its surrounding environment. Different microbial species have been suggest...

Do you want to study #cancer #microbe interactions using #organoids and #organ #chips? Have a look at our guide to co-culture platforms, just out in Int J Cancer with Jens Puschhof, Hans Clevers, Eran Elinav and fellow @emil-dkfz.bsky.social colleagues: onlinelibrary.wiley.com/doi/10.1002/...

Another part of my former PhD work at @mpi-mp-potsdam.bsky.social is now finally published. I am especially happy about the parallel release of the journal article in @csbjournal.bsky.social (doi.org/10.1016/j.cs...) and the dataset through @nfdi4plants.bsky.social (doi.org/10.60534/ecj...).

Super cool work (and great videos 😉), congrats @arispapargyriou.bsky.social, @maxreichertmd.bsky.social and team!

The 2024 generation Nature Cancer - Twelve early-career researchers who embarked on their independent research paths in 2024 reflect on their experience from their journey so far, describe the opportunities they...

Thrilled to see @emil-dkfz.bsky.social @dkfz.bsky.social among the 12 new cancer research labs featured in @naturecancer.bsky.social as part of "The 2024 generation". I loved reading the other authors' reflections on their career paths and ideas for their labs! Have a look: rdcu.be/d3R8r

Hyped to be at the #ESSB #spatial #biology conference together with some of my colleagues from the @saezlab.bsky.social . Great science, beautiful venue, looking forward to the next 1.5 days...

Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma - Nature Biomedical Engineering Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.

I am so excited to share the biggest (and best) part of my #PhD in @maxreichertmd.bsky.social lab
We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids
@natureportfolio.bsky.social
www.nature.com/articles/s41...

#Colorectal #Cancer #Starterpack.
Patient Advocates, Scientists, Physicians, Institutes and Journals with a focus on Colorectal Cancer.
Please comment/text to be added!
go.bsky.app/PGqU6zP

About one week left to apply! Open postdoc position for analysing environmental microbiome data, e.g. from @embl.org 's TREC expedition along the coastlines of Europe www.embl.org/about/info/t...

#Organoid #Starterpack #1 is now full (go.bsky.app/RmXgs6d).
Time for #Organoids #2/2: go.bsky.app/JVA5H2a
Already many great new arrivals & finds such as @batllelab.bsky.social, @saurlab.bsky.social & more!

#Organoid Starter Pack! 🤩

Courtesy of @jenspuschhof.bsky.social - lots of great organoid/#stemcell/#cellbiology research to follow.

RANK drives structured intestinal epithelial expansion during pregnancy - Nature The RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation.

Excited to share my latest paper, published today at @natureportfolio.bsky.social ! A big thank you to all our collaborators.

The paper shows how RANK drives intestinal epithelial expansion during reproduction.

#intestine #stemcells #pregnancy

www.nature.com/articles/s41...

An updated list with those added who wanted to join go.bsky.app/VVLoMPx

I'd love to be added!

Just joined: @jackstadt-lab.bsky.social!