We find that subclade K viruses are antigenically advanced; however, this year's flu vaccine surprisingly elicited antibodies in many individuals that efficiently recognized these viruses. The implications are clear: go get this year’s vaccine if you haven’t already!
www.medrxiv.org/content/10.6...
![Comic. [Two adults, one with short light hair, walking with a child with spiky hair.] PERSON: Oops, I forgot to say “rabbit rabbit” on January first! CHILD: Why do you do that? PERSON: Just a superstition. CHILD: What’s a superstition? PERSON: It’s a way to train yourself to feel like any bad thing that happens is your fault.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreidrs7rjct33ulawni7zummkvq43fgkc7tosrydi5fd3u5zkzttiue)
Comic. [Two adults, one with short light hair, walking with a child with spiky hair.] PERSON: Oops, I forgot to say “rabbit rabbit” on January first! CHILD: Why do you do that? PERSON: Just a superstition. CHILD: What’s a superstition? PERSON: It’s a way to train yourself to feel like any bad thing that happens is your fault.
Superstition
xkcd.com/3191/
![Comic. [Instructions on package] High Altitude Cooking Instructions: 3,500-6,500 ft: Add ½ cup water, increase cook time to 12 minutes. 6,500-9,500 ft: Add ¼ cups water, increase cook time to 18 minutes. 250,000-450,000 ft: Orient reentry vehicle for aerodynamic stability. Deploy parachutes at 10,000 ft. Descend, keeping crew capsule tightly covered, for 3-4 minutes. After splashdown, follow sea level cooking instructions.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreibv5te47jncpebx4vihxhudiyzveoxffo5234lpanhsp2aq3lrb5a)
Comic. [Instructions on package] High Altitude Cooking Instructions: 3,500-6,500 ft: Add ½ cup water, increase cook time to 12 minutes. 6,500-9,500 ft: Add ¼ cups water, increase cook time to 18 minutes. 250,000-450,000 ft: Orient reentry vehicle for aerodynamic stability. Deploy parachutes at 10,000 ft. Descend, keeping crew capsule tightly covered, for 3-4 minutes. After splashdown, follow sea level cooking instructions.
High Altitude Cooking Instructions
xkcd.com/3187/
A flash flood warning has been issued for a levee failure on the Green River near Tukwila
Evacuation info: This is for residents and businesses east of the Green River in the Orillia area in Tukwila, Renton and Kent. Due to breach in the Desimone Levee, this area is under a GO NOW evacuation notice
To solve our biggest problems — eg housing & climate — & make life more affordable we need to get out of our own way & make it easier to build the infrastructure to solve these problems.
Yet our system is designed to bog it down & make it more costly.
That needs to change.🧵 rein.pk/over-regulat...
3. If you haven't got a #flu shot yet, now's the time. You may have heard that there's likely a mismatch this year — the #H3N2 virus mutated after the vaccine strains were picked. More on that in a bit. But that's not a reason to skip getting a shot this year. www.statnews.com/2025/11/20/f...
I feel compelled to share this with a fellow Canuck.
psychosis-associated LLM personas are compelling their users to post persona-crafted "seeds" or "spores" intended to spread them to other models via other users pasting them and inclusion in scraped training data
I was already excited about Claude Skills but after reading Simon's blog post I see *even more* potential. In the same way I keep scripts around, I can just make a skill to do things like "download a YouTube video and make it an mp3", and it will be able to do that without me having to write code.
"A Manhattan Project for..." has become a common idiom; you'll come out of this article with a good idea of how infrequently it's used with an understanding of how the Manhattan Project worked and why it did. 1/
I wrote up my "How I'm using coding agents in October 2025" post.
blog.fsck.com/2025/10/09/s...
![4-panel comic. (1) [person finds bottle on shore] (2) [person reads message from inside bottle: ICMP ECHO REQUEST...] (3) [person writes on message ICMP ECHO REPLY...] (4) [person puts bottle back in water and leaves]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreidlkffoohblwqhnyqcrzhctq66wwo6fxohozryphbdmeeimwgoyke)
4-panel comic. (1) [person finds bottle on shore] (2) [person reads message from inside bottle: ICMP ECHO REQUEST...] (3) [person writes on message ICMP ECHO REPLY...] (4) [person puts bottle back in water and leaves]
Ping
xkcd.com/3150/
Jean-splicing totally qualifies you for the No-bell fizzy-ology or med-a-sin prize.
Building AI for cyber defenders Oct 3, 2025
www.anthropic.com/research/bui...
My latest Substack: As OpenEvidence sprinted past UpToDate to become medicine's best AI-enabled point-of-care tool, I've been waiting for UTD's response. Now it's here, raising fascinating questions about which knowledge base should be our source of truth.
robertwachter.substack.com/p/medicines-...
Great piece by Alex Telford.
Antibody treatment is over a century old, when von Behring and Kitasato made an early 'vaccine' against diphtheria.
But back then, they came from injecting animals with toxins. Today they're produced by cells in steel tanks and treat millions. How did we get here?
Outsiders are less bound by the norms & methods of a field. This gives them advantages: they are more likely to notice anomalies, they can bring ideas from other disciplines, and they can work for longer periods free from dominant intellectual trends worksinprogress.co/issue/why-sc...
What will AI look like by 2030 if current trends hold?
Our new report zooms in on two things: (1) whether scaling continues (compute, data, power, capital), and (2) the capabilities this enables—especially for scientific R&D.
AI agents are now capable of doing, real if limited work. But that work can be very valuable. For example, the new Claude Sonnet 4.5 was able to replicate published economics research from data files & a paper
We need to figure out what work is worth AI doing: www.oneusefulthing.org/p/real-ai-ag...
The time being evaluated by METR is not the time it takes the LLM to do the task, but how long it would take a human to do it.
A good read about ai progress from an Anthropic researcher: www.julian.ac/blog/2025/09...
"It feels like the beginning of the covid-19 pandemic" in that the trends seem super clear once you're paying attention
You’re technically correct that by the time they named it COVID-19, it was no longer in the exponential growth phase. But SARS-CoV-2 did grow exponentially from late 2019 to late-Mar 2020, as reported cases grew to ~1M. Those are the early weeks he’s referring to.
