Denis LJ Lafontaine

A new ´tour de force’ by Suzuki 先生 Bravo 👏 🤩

Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria Ishiguro et al. identify stereoselective ribose-backbone methylations in the peptidyl-transferase center of E. coli ribosomes, installed by the cobalamin-dependent enzyme RlmX. These methylations, together with ho5C2501, are specifically induced under hypoxia. The hypoxia-induced modifications activate ribosomes, enhancing translational capacity and thereby promoting bacterial fitness in anaerobic conditions.

Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria Online now:

Amazing Talk at the Ribosome meeting in Cambridge 🤩

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

www.nature.com/articles/s41...

Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...

New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...

TRANSLACORE, a European network to coordinate research on translation regulation in cancer Explore the article collection: TRANSLACORE, a European network to coordinate research on translation regulation in cancer. Published in RNA Biology.

Very happy to see our work, "The implication of non-AUG-initiated N-terminally extended proteoforms in cancer," in this special collection of RNA Biology! 💫 Thanks to @lafontainelab.bsky.social and TRANSLACORE for the opportunity to contribute to this collection!

www.tandfonline.com/journals/krn...

A Fantastic collaboration with amazing scientists 🤩☀️

Spending quality time with good friends at the #Helicase conference in beautiful Lisbon #RNA

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...

Transfer RNA acetylation regulates in vivo mammalian stress signaling An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.

www.science.org/doi/10.1126/...

Message to my 11 followers in Bluesky:

We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!

Details and registration: www.eventsforce.net/hg3/frontend...

The Organizing Committee

come join!

How has native RNA sequencing contributed to epitranscriptomic research? This is one of the main questions we addressed in our recent review by @evamarianovoa.bsky.social and I now live in Molecular Cell #RNAsky #RNA #nanopore
authors.elsevier.com/a/1kS2f3vVUP...

Awesome. Can you post the link to the PDF. Thank you and 🎄

The ´Belgium’s Treetop Adventure: Cycling Through Trees’ 🌳 I strongly recommend 😉 Happy Holidays 🎄

Thank you for highlighting an Amazing collaboration with Eva Novoa @evamarianovoa.bsky.social

Ribosome Fingerprints: A Breakthrough in Early Cancer Detection Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.

Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.

Absolutely, would be delighted

Sounds exciting ! Wonder if processing is also affected,…

And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬

More details via www.imb.de/jobs
Application deadline is 5 January 2025

#sciencejobs #resilience #biostatistics

Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025

Identification of coilin interactors reveals coordinated control of Cajal body number and structure This study identifies new Cajal body components and tests their roles in the formation of these nuclear membraneless organelles. Imbalances in the levels o

Published online today @jcellbiol.bsky.social you will find our latest work on Cajal bodies. 😅🎉 It has been a joy to work with Chuyue Zhang, Dahyana Arias Escayola, and colleagues! doi.org/10.1083/jcb....
#RNAsky #RNAbiology

Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...

We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...

Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics

Hot off the press: new review @AnnualReviews discusses recent time-resolved cryo-EM studies visualizing how ribosome moves and interacts with translation factors to achieve efficient and accurate translation.
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9

Excellent! Could you add me to this Translation pack. Many thanks 🤩

Awesome 🤩 Can you add me to the pack. Many thanks

Are you a PhD student or postdoc working in Belgium and on a #cellbio or #devbio or #evodevo topic, consider applying for a travel grant to support travel to the next conference you want to attend! Check out details on our website www.bscdb.be/membership-g...