Javi Ibarrondo

Thirty-six solutions to stabilize Earth’s climate An updated visual assessment tool can bridge the gap between climate research and political action

Thirty-six solutions to stabilize Earth’s climate | Science www.science.org/doi/10.1126/... 🧪

Protein therapy with self-amplifying RNA Self-amplifying RNA improves heart function after myocardial infarction in mice and pigs

Protein therapy with self-amplifying RNA | Science www.science.org/doi/10.1126/... 🧪

Baby-to-baby strain transmission shapes the developing gut microbiome - Nature A metagenomic survey of babies attending the first year of nursery detected extensive baby-to-baby microbial strain transmission, pointing to social interactions in infancy as crucial drivers of infan...

www.nature.com/articles/s41... 🧪

Stem cells provide a potent treatment for frailty Elderly people with frailty, which affects up to one-quarter of over-50s, increased their endurance after a single dose of stem cells.

www.nature.com/articles/d41... 🧪

Physiological aging in three dimensions Aging is characterized by progressive structural and functional decline, driven partially by epigenetic alterations. While changes in DNA methylation, histone modifications, and chromatin accessibilit...

Aging and senescence alter 3D chromatin organization, including compartments, topologically associating domains (TADs), and enhancer–promoter interactions, leading to altered gene expression.

Physiological aging in three dimensions: Trends in Cell Biology www.cell.com/trends/cell-... 🧪

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments in aging and Alzheimer’s disease models by targeting GPI-anchored proteins on brain endothelial...

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature: Cell www.cell.com/cell/fulltex... 🧪

Many heat-stressed tropical insects are reaching their limits Vast study in Peru and Kenya confirms limited defenses against rising temperatures, redoubling climate concerns

Many heat-stressed tropical insects are reaching their limits | Science | AAAS www.science.org/content/arti... 🧪

GLP-1 drugs linked to lower addiction rates in large study of veterans The treatments appeared to help prevent a wide range of substance use disorders and reduce serious harms from existing ones

GLP-1 drugs linked to lower addiction rates in large study of veterans | Science | AAAS www.science.org/content/arti... 🧪

Distinct spatial organization governs oral mucosal immunity - Nature Immunology Moutsopoulos, Williams and colleagues show oral mucosal barrier tissues exhibit dynamic zonal immune cell environments, including tonic inflammatory features in healthy individuals and development of ...

www.nature.com/articles/s41... 🧪

Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates - Nature Immunology WIN332 is an HIV-1 Env protein designed to elicit a new class of Asn332-glycan-independent antibodies (type II) to the V3-glycan site of Env. WIN332 immunization rapidly induces type-II V3-glycan anti...

www.nature.com/articles/s41... 🧪

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory - Nature Immunology Schober and colleagues show that effector CD8+ T cells undergo metabolic shutdown, CD8+ central memory T cells are the most metabolically active, and naive-like memory T cells are quiescent during the...

www.nature.com/articles/s41... 🧪

Microbes might be able to planet hop on asteroid shrapnel Experiment confirms bacteria could survive being blasted off world by impact

Microbes might be able to planet hop on asteroid shrapnel | Science | AAAS www.science.org/content/arti... 🧪

Delays in awards and funding calls worry NIH-funded researchers Many programs may be pushed into the next fiscal year, and some could face funding gaps

Delays in awards and funding calls worry NIH-funded researchers | Science | AAAS www.science.org/content/arti... 🧪

Stem cell therapies ‘come of age’ with two conditional approvals in Japan Induced pluripotent stem cells could help treat diseased hearts and brains

Stem cell therapies ‘come of age’ with two conditional approvals in Japan | Science | AAAS www.science.org/content/arti... 🧪

Did ancient Greek priestesses brew a mind-bending potion drunk by Cicero and Marcus Aurelius? Researchers found the psychedelic elixir would have been possible to make using ingredients and techniques available in ancient Greece

Did ancient Greek priestesses brew a mind-bending potion drunk by Cicero and Marcus Aurelius? | Science | AAAS www.science.org/content/arti... 🧪

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The theory of epidemics with altruism | PNAS Social distancing can mitigate the spread of diseases in humans and animals. Social distancing allows susceptible individuals to protect themselves...

The theory of epidemics with altruism | PNAS www.pnas.org/doi/10.1073/... 🧪

‘Truly spectacular’ drug for sleeping sickness simplifies treatment, raising hopes for eradication European regulators greenlight new one-dose compound that could help African countries get rid of an ancient burden

‘Truly spectacular’ drug for sleeping sickness simplifies treatment, raising hopes for eradication | Science | AAAS www.science.org/content/arti... 🧪

Suspended small business research programs derail development of gene therapies, hip implants, and more Congressional impasse has halted billions in research funding for innovative technologies

Suspended small business research programs derail development of gene therapies, hip implants, and more | Science | AAAS www.science.org/content/arti... 🧪

How will we know if AI is smart enough to do science? New tests gauge whether large language models can use their deep troves of knowledge to actually make discoveries

How will we know if AI is smart enough to do science? | Science | AAAS www.science.org/content/arti... 🧪

Meet three scientists who said no to Epstein The warning signs included a web search, a mother’s doubts, and inklings of a “sexist attitude”

Meet three scientists who said no to Epstein | Science | AAAS www.science.org/content/arti... 🧪

Every senator who voted to confirm RFK Jr owns this tragedy. Every single one.

When I lost my university email, my identity as a scientist took an unexpected hit “My scientific life [had] gathered there, thread by thread,” this researcher writes

When I lost my university email, my identity as a scientist took an unexpected hit | Science | AAAS www.science.org/content/arti... 🧪

Private money cannot replace public funding of science Who should pay for American science? In the current political climate, many are looking to the private sector to compensate for cuts in public funding. At the Harvard School of Public Health—particula...

Private money cannot replace public funding of science | Science www.science.org/doi/10.1126/... 🧪

NSF officials break silence on how AI and quantum now drive agency grantmaking Leaders acknowledge White House role in controversial moves

NSF officials break silence on how AI and quantum now drive agency grantmaking | Science | AAAS www.science.org/content/arti... 🧪

Surprising partner preference found in matings between Neanderthals and modern humans Male Neanderthals tended to pair up with female modern humans, but whether intercourse was consensual is unclear

Surprising partner preference found in matings between Neanderthals and modern humans | Science | AAAS www.science.org/content/arti... 🧪

Treating fetuses with stem cells proves safe in milestone spina bifida trial The study is now scaling up to do more in utero procedures and evaluate effects on disability as children grow

Treating fetuses with stem cells proves safe in milestone spina bifida trial | Science | AAAS www.science.org/content/arti... 🧪

Ageing promotes microglial accumulation of slow-degrading synaptic proteins - Nature Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.

www.nature.com/articles/s41... 🧪

Synthesizing scientific literature with retrieval-augmented language models - Nature A specialized, open-source, retrieval-augmented language model is introduced for answering scientific queries and synthesizing literature, the responses of which are shown to be preferred by human eva...

www.nature.com/articles/s41... 🧪

Controversial citizenship question added to upcoming census test Researchers worry question plus other changes will reduce accuracy and boost costs of 2030 count

Controversial citizenship question added to upcoming census test | Science | AAAS www.science.org/content/arti... 🧪