Aashli Pathni, PhD

#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.

Hi! Is there still a hiring freeze in place/is the position still open?

THIS IS HUGE! TWO Phase I HIV vaccine clinical trials have demonstrated that a stepwise mRNA-based vaccination strategy can SUCCESSFULLY activate AND advance immune responses toward producing broadly neutralizing antibodies (bnAbs), a CRITICAL milestone in HIV prevention. Let’s talk about that! 🧪🧵⬇️

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

New technique expands tissues so hundreds of biomolecules can be seen inside cells A new tissue expansion method developed by Janelia and University of Wisconsin-Madison researchers enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules

🥼A new tissue expansion method developed by researchers in the Wang & Tillberg labs & collaborators @uwmadison.bsky.social enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules at the single cell level in their native locations ➡️ hhmi.news/4ixHOZZ

Hydrogel Design - Make better hydrogels. A scientific communication platform for hydrogel design by Nate Richbourg

Sharing all my research via a tutorial website was the most unique idea I had during my PhD. I took advantage of my years of blogging experience via Wordpress, but it still took a lot of work. I'm glad it has connected me to scientists across the globe. Visit hydrogeldesign.org to learn more!

The Evolution of Bacteria on a “Mega-Plate” Petri Dish (Kishony Lab) YouTube video by Harvard Medical School

In 2016, the Kishony Lab at Harvard Medical School put together this demonstration of acquired antibiotic resistance in E. coli bacteria, creating a mega-Petri dish (2' x 4') with a stepped gradient of antibiotic.

Seeing the mutants emerge & spread is an elegant demo of evolutionary change.

How does the brain work?

Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵

🧠📈

A huge day for mapping in life science!
—the mammalian brain, most extensive yet (10 papers @nature.com journals)
nature.com/articles/s41...
@alleninstitute.bsky.social
—a comprehensive map of the human cell->sub-cellular
nature.com/articles/s41...
—complete ape genomes
nature.com/articles/s41...

Enabling global image data sharing in the life sciences - Nature Methods This Perspective provides a roadmap toward globally federated open data resources for bioimaging data.

Picture this! What if the scientific community had a standardized system for storing and sharing image data?

In a new @naturemethods.bsky.social perspective, an international team calls for investment into long term and openly accessible resources: www.nature.com/articles/s41...

🧪 #cellbio

IL-1β+ macrophages and the control of pathogenic inflammation in cancer While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb

🧬 February's most-read Genetics paper looks at how #RNA travels between cells to control genes across generations #epigenetics: buff.ly/ulMGsBH

Have a paper people should see? See what our Editors look for: buff.ly/HmuOWDp

I figured that the one month anniversary of my first ever publication is a good time to join bluesky! Many thanks to Nathan Shugarts Devanapally and Antony Jose for letting me work on this in the first half of my PhD career. More on this story soon (hopefully in the coming year)!

THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️

An oral norovirus vaccine tablet was safe and elicited mucosal immunity in older adults in a phase 1b clinical trial An oral norovirus vaccine tablet is safe and induces strong mucosal and systemic immune responses in adults aged 55 to 80 years.

In the US alone, each year, norovirus causes ~20 million acute gastroenteritis cases, 70,000 hospitalizations, up to 800 deaths, at a cost of ~$10.6 billion annually.
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...

In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.

I wonder if spreading extremely encouraging experimental results on helping treat pancreatic cancer with *gasp* mRNA vaccines may help people who have villainized them come around. This is a good press release on the study and links to the Nature paper. www.mskcc.org/news/can-mrn...

‘The Interview’: Ed Yong Wants to Show You the Hidden Reality of the World The Pulitzer Prize-winning science writer talks about burnout from covering the pandemic and how bird-watching gave him a new sense of hope.

The most achingly beautiful explanation of what science is, from @edyong209.bsky.social: “the idea that much of the world is hidden from us, that we don’t perceive it and don’t understand it, and that it is worth understanding and it is necessary to understand.”

www.nytimes.com/2025/02/22/m...

blue grid of mitosis images in watercolor

watercolor of red blood cells on pink

ink painting of neurons in blue and gray

watercolor brain with wavy pattern

New #sciart
Original ink and watercolor paintings
artologica.etsy.com 🧪🐡🧠

At @science.org today, an important new way we can make major headway into immunologic and infectious diseases. Sequencing the lymphocyte B and T cell receptors and A.I. to accurately make the diagnosis!
www.science.org/doi/10.1126/science.adp2407
A seminal study by @anshulkundaje.bsky.social et al

Single-molecule live-cell RNA imaging with CRISPR–Csm - Nature Biotechnology Single-molecule live-cell fluorescence in situ hybridization uses an RNA-targeting CRISPR–Csm complex to image and track endogenous RNAs.

Visualizing RNA in live cells using CRISPR
nature.com/articles/s41...

Caillier, @pwoakes.bsky.social et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. https://buff.ly/4jU4e9C

In #Mechanobiology 2025: https://buff.ly/3EK0uaq

#medsky#pedsky#idsky#immunosky 🧪
In the midst of all of the scary headlines recently, I thought I could take a moment to share a bit of good news: for the first time in history, a malaria vaccine with >90% efficacy seems to be within reach!

Here’s why that’s a really big deal for EVERYONE 🧵

Schematic overview on how MicroSpit operates. It can split superimposed structures in fluorescent image channels by using a suitably trained AI.

Concrete example for how MicroSplit unmixes four superimposed structures.

Immagine you could image two cellular structures in the same fluorescent channel and still reliably get them separated afterwards…
What would you do with this?

Now… what would you do if that also worked with 4 structures at once? 👇 #MicroSplit #preview🧵