Really interesting article about fracture in developing tissues. For a deep dive into examples across species, you can also check out @rashmi-priya.bsky.social and @torres-sanchez.bsky.social's recent Review in Development @dev-journal.bsky.social
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journals.biologists.com/dev/article/...
“In biology, breaking isn’t always a failure,” said the developmental biologist Rashmi Priya (right). “It’s often a necessary step in building something new.”
www.quantamagazine.org/break-it-to-...
We had covered the history of traction force microscopy (TFM) earlier:
bsky.app/profile/epim...
But what about applying TFM into more physiologically relevant systems, such as those in 3D?
I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.
Sometimes, the only way to build back up is to let everything fall apart. This is certainly true at the cellular level. www.quantamagazine.org/break-it-to-...
Interested in a PhD in collective cell migration & mechanobiology?
I'm looking to support a candidate applying for a fully funded UK/Home PhD. The project studies the biophysics of migrating cells, using force measurements & optogenetics, with collaborators in Japan.
#mechanobiology #PhD
eb4bm.org
Congrats, Carlos!! Very well deserved!!
I’m thrilled to share that I will join @gustaveroussy.fr as a Group Leader!
Our objective: to understand how mechanochemical feedbacks regulate tumor dynamics and plasticity, with the overarching goal of bridging tissue mechanobiology and tumor pathophysiology using human organoids.
Excited to share our new review in @dev-journal.bsky.social on tissue phase transitions during development!
@karengrace12.bsky.social @nicolettapetridou.bsky.social
🔗 doi.org/10.1242/dev....
Our cells are experts at navigating inherently noisy and complicated environments.
EMBL researchers are using theoretical physics approaches to uncover fundamental principles behind how cells use complex information to self-organise.
www.embl.org/news/science...
We‘re looking for a motivated Master student to join our team!
Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬
Then please apply!
#optogenetics #metabolism #devbio #hESCs
Please RT. Thank you!🙏
Jajajaja
Development builds... But it also breaks!
Planarians split to reproduce. Hydra tears open a mouth. Embryos fracture to make cavities.
Failure? No. Fracture is essential to development.
Our new review on fracture physics and its uses in development:
journals.biologists.com/dev/article/...
Congratulations, Rashmi!! Super well deserved!!
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics
Congrats, Wolfram!!!
Empire. Oil. Guyana.
Good luck with the move! And congrats on the paper!
Picture of Alejandro in a blue t-shirt and dark wire-rimmed glasses, sitting in front of a laptop
Transitions in development – an interview with Alejandro Torres-Sánchez
We caught up with Alejandro @torres-sanchez.bsky.social from @embl.org Barcelona to talk about his path to becoming a group leader, ongoing collaborations and addressing gender imbalance in the lab.
doi.org/10.1242/dev....
Many thanks for the opportunity to talk a bit about our work and my career @dev-journal.bsky.social! And many thanks for the interview, @ingridtsang.bsky.social! I really enjoyed it!
How does signalling control cortical tension?
Using optogenetics and AFM, we show that myosin recruitment and cortical tension increase proportionally with RhoA signalling.
More here:
www.biorxiv.org/content/10.6...
Super work by Pierre Bohec with Guillaume Salbreux and @dianakhorom.bsky.social
My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
Researchers at EMBL Barcelona have launched LimbNET, a new online platform that integrates computer modeling, experimental data, and 2D live simulations for limb development.
www.embl.org/news/science...
Come to Biomalpar xxii!!! We have an outstanding line up of speakers!!!
It is a true honor to be an organizer of Biomalpar. It was the first conference I ever attended during my 2nd PhD year so it feels special.
And don't miss the beautiful poster image from Hannah Fleckenstein!
Congratulations!!
Join EMBL's Interdisciplinary Postdoc Programme!
3 years funding, self-designed interdisciplinary project co-led between EMBL PI and PI in one of EMBL's actual, prospect or associate member states.
In particular: AI&Theory, use mathem. models, physics principles and AI
www.embl.org/about/info/p...
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
