#MicroSky Please RT
@erc.europa.eu-funded postdoc position in my lab to identify the molecular basis of prey-predator interactions using our favorite micro-vampire Bdellovibrio exovorus as a model.
Let's find what the bite is made of! ๐ง
Flexible start date.
Info: euraxess.ec.europa.eu/jobs/415877
Join @berasymbionts.bsky.social , @tatsuyanobori.bsky.social and us for a postdoc on the remarkable developmental biology of symbiosis!
Applications are due March 25th ๐ชฒ๐ฆ
@johninnescentre.bsky.social @thesainsburylab.bsky.social
The first version of FigTree was released nearly 20 years ago and it is still widely used (including by me). But there are currently 85 issues on the GitHub repo (github.com/rambaut/figt...) and some of them I donโt really like the look of.
Itโs finally out! Together with @embopress.org and
@reviewcommons.org, we conducted a structured side-by-side comparison of human peer review and our AI scientific review (see thread ๐๐๐๐ฅ).
Congrats Pedro
Beautiful work !
New preprint out on bioRxiv!
www.biorxiv.org/content/10.6...
Can conjugative plasmids be used to control plasmid and pathogen spread?
Follow me down the rabbit hole that led to this story ๐งต
There's still time to apply for this PhD position!
Nature research paper: Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor
go.nature.com/4rSfRRw
#NatMicroPicks
Aerobic archaeal-eukaryotic ancestor? ๐ฆ ๐ซ
The ancestor of eukaryotes may have combined hydrogen metabolism with aerobic respiration, shaping early cellular complexity.
#MicroSky
www.nature.com/articles/s41...
At long last! Check out the link to our publication in @nature.com to learn more. doi.org/10.1038/s415...
12/12
Eukaryogenesis in light of an expanded catalogue of Asgard genomes. a, Simplified, scaled timeline spanning from before the Last Asgard archaea Common Ancestor (LAsCA) to today. Thin bands mark predicted time ranges of relevant events (for example, GOE), thicker bands represent processes (for example, eukaryogenesis), and brackets indicate the period shown in b. The timeline further highlights milestones, including potential early eukaryotic fossils60 and the modern-day co-occurrence of Heimdallarchaeia and Alphaproteobacteria observed in this study (interaction likely originated earlier).
Fig. 1 | Expanded genomic diversity of Asgard archaea. a, Maximum-likelihood phylogeny based on 47 non-ribosomal markers (NM47)๎using the WAGโ+โC10โ+โR4 model with 100 nonparametric bootstrap pseudoreplicates, including 869 Asgardarchaeota MAGs and 309 outgroup genomes. The blue branches (lower right) indicate the new Asgardarchaeota classes, Ranarchaeia, and the recently proposed Asgardarchaeia4. The concentric rings denote (in to out): the predicted genome size, metabolic guilds based on Pfam clustering, sampling locations, and black stars on the outside mark MAGs added by this study. Asgard, Asgardarchaeia; Atabey, Atabeyarchaeia; Baldr, Baldrarchaeia; Frey/Jord, Frey/Jordarchaeia; Gerd, Gerdarchaeales; Heimdall, Heimdallarchaeaceae; Hel, Helarchaeales; Hermod, Hermodarchaeia; Hod, Hodarchaeales; Kari, Kariarchaeaceae; Loki, Lokiarchaeales; Njord, Njordarchaeales; Odin, Odinarchaeia; Ran, Ranarchaeia; Sif, Sifarchaeia; Thor, Thorarchaeia; Wukong, Wukongarchaeia. b, SR4-recoded phylogeny of the same genome set inferred with the model GTRโ+โC60โ+โG and 100 nonparametric bootstrap pseudoreplicates (Methods). This updated catalogue constitutes a large increase in the medium- to high-quality publicly available genomes (completeness >50% and contamination and redundancy <10%) with 65.3% from the Guaymas Basin and 34.7% from the Bohai Sea. The encircled numbers represent MAGS added by this study. The scale bars in both๎subpanels represent the average number of substitutions per site.๎Map created in BioRender; Appler, K. https://biorender.com/147ieoc๎(2025).
Our work is published today: โOxygen metabolism in descendants of the archaeal-eukaryotic ancestorโ. This was a huge effort lead by @katyappler.bsky.social. Extremely grateful to have been a part of this amazing project! ๐๐ฆ ๐งฌ
Links: www.nature.com/articles/s41...
www.nature.com/articles/s41...
You go, Katy! ๐
Iโm so proud of you, and so happy to finally see this in its final form!
Count me in on your corner to keep on cheering for you! Looking forward to doing more amazing science together ๐ช
Check @katyappler.bsky.social thread below for highlights and the full paper here: rdcu.be/e4A70
Hot eukaryogenesis news (is there any other kind?) - hydrogen production and aerobic respiration may have been present in the Asgard-eukaryotic ancestor - paper in @nature.com www.nature.com/articles/s41...
๐จ Hiring Alert! ๐จMy lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: ๐ฆ Synthetic Biology and๐ก๏ธ Bacterial Immunity. Come do great science with us in the middle of Paris! ๐ซ๐ท๐ฅ research.pasteur.fr/en/job/postd...
New paper from my team detailing a greatly expanded genomic database of Asgard archaea revealing of high energy metabolism those related to eukaryotes! Led by @katyappler.bsky.social lots of help from @jameslingford.bsky.social @valdeanda.bsky.social @kassipan.bsky.social doi.org/10.1038/s415...
Congrats Katy ๐ฝ๐ฝ๐ฝ
Figures are stunning.
Very eager to read
Bravo
Beyond thrilled to share that our study has been published!
This project encompasses years of work, including my thesis research on Asgard archaea in the @archaeal.bsky.social lab at @utmsi.bsky.social and
@texasscience.bsky.social!!!
#MicroSky #ArchaeaSky 1/12
Exploring the microbial "dark matter" just got easier๐ฆ ๐ฌ
Most #protists are uncultivated and tiny making electron microscopy a nightmare. A new, low-cost protocol allows single-cell tracking and field prep.
#microbiology #eukaryotes #MicroSky #ProtistsOnSky
doi.org/10.1111/jeu....
Characterization and description of plant-growth-promoting methanotrophic bacteria belonging to the genus of Methylocaldum
#microbiology #bacteria #MicroSky
doi.org/10.1016/j.sy...
Bravo
Very exciting
Preprint on the permeability of Gram+ bacterial cell wall from a few months ago. Intriguing findings, elegant methodology. Cell wall is largely impermeable to molecule sizes of mNeonGreen (27kDa) and above. How do larger secreted proteins get through? www.biorxiv.org/content/10.1... #microsky
Look at this ๐ #CryoEM
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Extremophile alert!
Registration is OPEN for the 2026 EMBO Archaeal workshop in Cambridge.
Spaces are limited, so register soon with an abstract if youโd like to give a talk.
If you canโt come in person, we are welcoming virtual attendees. So join us online where all talks will be screened!
Iโm looking for two postdoctoral scientists in experimental evolution to join my team from April 2026 (or soon after). Please share! fa-eosd-saasfaprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
Looking for a deep dive into oxidoreductase distribution, structural plasticity & evolution across prokarya?
This new paper has you covered. ๐ฃ
Big work just out from @pierresimongarcia.bsky.social , now a freshly minted PI.
Congratulations ! Looks amazing. ๐ฆ
We analyzed the distribution of 31 HORBEC in over 4,000 bacterial and archaeal genomes. We propose a homogeneous nomenclature of HORBEC and their components and developed a tool, HORBEC-Finder, for automatic annotation from genomes(try it here! doi.org/10.6084/m9.f...).
Finally, we reconstructed the labyrinthic evolutionary history of HORBEC, from two ancient modules to the wide diversity that we observe in contemporary organisms.
Passioned by #bioenergetics? Do not miss our new article on the evolutionary history of oxidoreductases with G. Borrel and @sgribaldo.bsky.social @archaeal.bsky.social @valdeanda.bsky.social @pasteur.fr @cnrs.fr @cnrsbiologie.bsky.social @natecoevo.nature.com (www.nature.com/articles/s41...).
Great talk
