Björn Rissiek

Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens - Nature Nanotechnology Engineered mucus-tethering bispecific nanobodies neutralize and entrap viruses to enhance mucosal immunity, preventing influenza infection and limiting SARS-CoV-2 transmission.

www.nature.com/articles/s41...

#medsky

We’re excited to introduce the new Hamburg #HertieNetwork fellows for the 3rd funding period: @felixfischbach.bsky.social, Märit Jensen, @brissiek.bsky.social & @janasonner.bsky.social. Looking forward to inspiring projects, discussions & collaboration across sites! #UKEHamburg #HertieStiftung

NAADP production in activated T cells is stimulated by Ca2+ and two distinct protein kinases
www.science.org/doi/10.1126/...

To conclude: a huge thank you to my fantastic team and to everyone who contributed to this project. Special thanks for support go to Florian Schmidt from the Nanobody Core Facility at the UK Bonn! Finally, I would like to express our sincere gratitude to our funder, the T. von Zastrow Foundation.

Over the summer, we were able to launch our first immunization campaigns and completed this intensive setup and implementation phase right on schedule by early December. In early 2026, “the big search” for the top clones against our target antigens will begin!

a stable and pasture, as well as establishing immunization protocols (protein, cDNA via gene gun). In parallel, a dedicated sample-processing container was installed, allowing us to process blood samples at the end of the immunization phase on site – from PBMC isolation all the way to cDNA synthesis

Last year, my group launched a project funded by the T. von Zastrow Foundation that truly took all of us into new territory: the establishment of our own #Nanobody Discovery Platform. We genuinely started from scratch – including setting up our own alpaca facility with five female alpacas…

Guys, it is great what you are doing! But please: check your AI generated images, e.g three finger kid on the left

Yesterday, our first immunization campaign finished. We started late (and finished at 2:00 am 🤯) but everything went well. Lots of PBMCs and good RNA yield 🥳. Big thx to our campaign front runners Gaby 🦙 and Justy 🦙

What happened to the left hand of the poor girl on the very right? 😉

Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue | EMBO reports imageimageStressed brown adipocytes release extracellular ATP, which acts as a paracrine signal via P2X4 and P2X7 receptors on macrophages, initiating BAT inflammatory remodeling and degeneration. Blocking this purinergic signaling axis prevents ...

Fantastic study by Michelle Jäckstein and Jörg Heeren of #SFB1328. Only the inhibition of both - #P2X7 and #P2X4 - protects from BAT inflammation!!! It was a pleasure to collaborate! Hope this inspires others to check P2X4/P2X7 double inhibition in their models! www.embopress.org/doi/full/10....

If only one device is messed up and pings the wrong PW your ACC is blocked and you have to run to the IT department to unlock it and start over again => the week of horror

Been there…we have the “two weeks of horror” when we have to change or work PW (twice a year). If you do not manage to do it properly on all your devices you are doomed. Strategy: switch off all affected devices (6 in total in my case) and sequentially restart them with the new PW… so I feel you!

Hey #IUIS2025 participants, check out our poster on Wednesday, August 20, 12:15 - 13:45 | Poster Area (Hall X5) #neuroimmunology. We brought data from our new "BrEndO" mouse model for cerebral vasculitis #CD8 #Tcells #immunology

collage of pictures of

Pretty certain running a lab is mostly about making signs to avoid inconveniences & minor catastrophes. 😊

Today, our blood sample preparation container arrived. Still needs to be filled with equipment 😊 then we are ready for the first blood samples in October #nanobodies #vhh #antibodies #immunology

Boost #1 of Campaign #1: done 🦙😊

BLACK SABBATH - "War Pigs" from 'The End' (Live Video) YouTube video by Black Sabbath

Rest in peace Ozzy 🥲 www.youtube.com/watch?v=zY5n... one of my favorite Black Sabbath songs

#HotFromThePress !!

What if instead of analyzing 4-6 pathology markers you could check >100 in the *same* sample?

@maltekuehl.com & co @puellesv.bsky.social lab introduce #PathoPlex, method that could even predict disease

Full www.nature.com/articles/s41...
@focalplane.bsky.social @nature.com 🧪🔬

Wissenschaftweltschmerz! If you're a scientist, it's what you're feeling.

It’s hard being a scientist these days and I’ve captured that indescribable feeling that we are all facing in a new word!!

open.substack.com/pub/profkap/...

Today, we startet our first #nanobody discovery campaign by immunizing two of our alpacas, one by s.c. protein injection and one by gene gun. Crossing our fingers for a good HcAb response 🤞🏻💪🏻

A warm welcome to our newest #nanobody discovery team member! “Occi” arrived this weekend and smothly joined the herd. Soon, she will help us generating new #nanobodies against antigen targets used in research and/or for medical application

Should I check this #alpaca for #nanobodies conferring resistance to electric shock? … or should I first check the electric fence energiser 😆 #vhh #antibody

Our alpaca mares have their summer coat since yesterday. Ethics are approved, antigen production is ongoing, and we hope to start the first round of immunization in July. Super excited!!! 🦙🧬🔬👨‍🔬

Opinion | The Science I Would Be Doing if I Weren’t in ICE Detention

gift link

www.nytimes.com/2025/05/13/o...

I have a particular set of skills The first step to using them is saying “I don’t know”

What does a science PhD really teach you? The ability to say “I don’t know, but I can find out.”
open.substack.com/pub/profkap/...

Every 10 seconds vaccination saves a life. Immunization for all is humanly possible.

Vaccines have saved 154 million lives in the past 50 years. A reminder of what is #HumanlyPossible. Science saves lives.
#VaccinesWork

bit.ly/wiw2025

And here is the editor @pchoern.bsky.social Welcome to bluesky

It is always a pleasure to get young students enthusiastic about science! A few days ago we had a whole class in our department, showcasing #Nanobody research. What can I say - it was fun! Hope to see some of you around on campus some time! #sfb1328

Flow Cytometric Analysis of Mouse Brain CD8+ T Cell Activation Cytotoxic CD8+ T cell lymphocytes are pivotal for fighting infections with intracellular pathogens, e.g., viruses. Moreover, recent studies have elucidated the role of CD8+ T cells in various neuroinf...

I am happy to report that our chapter on "Flow Cytometric Analysis of Mouse Brain CD8+ T Cell Activation" is out now! It is part of a book on "T cell activation" curated and edited by Björn-Philipp Diercks of #sfb1328
link.springer.com/protocol/10....