Federico Nichetti

Navigating the complexities of pancreatic ductal adenocarcinoma: A review on therapeutic models and RAS inhibitors Pancreatic cancer is one of the most lethal types of cancer, known for a poor prognosis. Currently, the standard of care for unresectable tumors consi…

www.sciencedirect.com/science/arti...

Genomic profiling unlocks new treatment opportunities for ampullary carcinoma Ampullary carcinoma (AC) is a rare disease with an abysmal prognosis and few treatment options. The molecular landscape and its therapeutic implications remain inadequately understood. This study aims...

Genomic profiling unlocks new treatment opportunities for ampullary carcinoma - @myesmo.bsky.social www.esmoopen.com/article/S205...

Systemic territoriality in academia: The Gollum effect’s impact on scientific research and careers Scientific progress depends on open collaboration and thus resource sharing, but possessive and territorial behaviors, which we call the Gollum Effect, threaten this ideal. This study reveals widespre...

www.cell.com/one-earth/fu... As much as I don’t like doctors say “MY patient” rather than “I patient I treat”, I don’t like researchers say “MY study, MY project”. Science is sharing.

Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational ... In this international retrospective cohort study from the Trans-Atlantic Pancreatic Surgery Consortium, the independent prognostic factors for overall surv

academic.oup.com/bjs/article/...

The highest cited original research publications in Pancreatic Cancer from 2020 to 2024 by Anirban Maitra - OncoDaily The highest cited original research publications in Pancreatic Cancer from 2020 to 2024 by Anirban Maitra / Abderezak Zebboudj, Abhishek Doshi, Adrienne Kaya

oncodaily.com/science/215119

Dissection of Progressive Disease Patterns for a Modified Classification for Immunotherapy This study examines a modified progressive disease classification and its association with postprogression survival in patients treated with atezolizumab across various solid tumors.

Can patterns of progression on IO, inform future decisions?

-1377pts from 5 ph 3 trials used to create 3 PD risk levels
- low (⬆️existing lesions), intermediate (new lesions), high (both)
- risk score assoc w post-PD OS across tumors

Prognostic, so far #LCSM

jamanetwork.com/journals/jam...

Whole genome and transcriptome analyses of pancreatic acinar cell carcinoma elucidates mechanisms of homologous recombination deficiency and unravels novel relevant fusion events Pancreatic acinar cell carcinoma (PACC) is a rare pancreatic tumor with a heterogeneous clinical course and, except for radical surgery, limited treat…

www.sciencedirect.com/science/arti...

PDAC: advances in tumour microenvironment, microbiome and AI Nature Reviews Gastroenterology & Hepatology, Published online: 20 December 2024; doi:10.1038/s41575-024-01030-yPancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on elucidating the…

New online! PDAC: advances in tumour microenvironment, microbiome and AI

Pancreatic Adenocarcinoma: Long-Term Outcomes of Adjuvant Therapy in the ESPAC4 Phase III Trial PURPOSEThe ESPAC4 trial showed that adjuvant chemotherapy with gemcitabine plus capecitabine (GemCap) produced longer overall survival (OS) than gemcitabine monotherapy. Subsequently, the PRODIGE24-CC...

ascopubs.org/doi/10.1200/... Long-Term Outcomes of Adjuvant Therapy in the ESPAC4 Phase III Trial

Molecular Characterization and Clinical Relevance of MGMT‐Silenced Pancreatic Cancer O6-methylguanine-DNA methyltransferase (MGMT) silencing is a validated biomarker in glioblastoma but has not been deeply investigated in pancreatic cancer (PAC). We show that MGMT silencing occurs in...

onlinelibrary.wiley.com/doi/10.1002/...

Our latest in @naturecomms.bsky.social from @danafarber.bsky.social / @mskcc.bsky.social collaboration: AI to extract cancer outcomes in EMR!

www.nature.com/articles/s41...

Same, can I be added? Thanks!

Novel Therapies for Pancreatic Cancer ascopubs.org/doi/10.1200/...

Did I Mess Up Today? | JCO Oncology Practice

“Recognizing that oncology practice remains, to some extent,
an art, it is dif cult to measure what makes any of us
competent, compassionate, and effective oncologists” ascopubs.org/doi/10.1200/...