TRAstonDrs

#Medsky🧪 #pedsky #IDsky #Neurosky #publicheath
#Subacutesclerosingpanencephalitis (SSPE) is a rare complication of measles affecting only 1 in 50,000 cases. However, it can be prevented through the MMR vaccine. The legacy of the #Measles remains a concern for unvaccinated children.

A friend’s father - not biological - was infertile due to mumps, my own father was also affected, but only in one testicle. You would have thought that a US administration that cared about declining birth rates might want to promote vaccination 💉

Simba snoring to the moon

What’s a perfect job on a Saturday morning❣️
Here you go . Sleep in and relax with Simba .

Good riddance…

The world awakens to a vibrant tapestry of colours at sunrise.

There is kindness everywhere
in different proportions, and more
goodness and tenderheartedness
than we read of in the moralists.
Elizabeth Barrett Browning

Life expectancy is one of the parameters I was keeping an eye on… and warned about years ago before we “opened up” in Australia.

We’ll see how this plays here, but I’m very sad for my country of birth.

The US is using repurposed Iranian drone technology to attack Iran – a military expert explains why Struck by the success of large-scale, low-cost drone attacks, the US made covert efforts to capture Iranian Shahed-136s for technical analysis.

Looking to cut costs in military production, 🇺🇸 sought inspiration from the Iranian Shahed drone.The story of how one side’s innovation came to be the other’s weapon of choice reveals a lot about the nature of modern warfare. @theconversation.com
theconversation.com/the-us-is-us...

CDC: Unvaccinated international traveler spread measles to 17 other travelers to, within US The index patient had a fever, persistent cough, cold-like symptoms, and conjunctivitis (“pink eye”) during travel.

#Medsky🧪 #IDSky #publichealth
Recap: #Measles cases are rising. Multiple measles transmission events are associated with a single unvaccinated traveller arriving in 🇺🇸 May 2025.
@cidrap.bsky.social
www.cidrap.umn.edu/measles/cdc-...

They also define another case of allelic bias contributing to variable expressivity of an IEI gene.

associated with inborn errors of immunity that include a component of NK cell dysfunction but may also have other immune or extra-immune dysregulation .
These findings link another member of the core replicative helicase complex to IEI & highlight the sensitivity of NK cells to these variants.

especially from the Herpesviridae family . Though NKD is rare, 4 members of the CDC45-MCM-GINS (CMG) helicase are associated with NKD, including MCM4 ,GINS1, MCM10 & GINS4
In addition, other genes associated with cell cycle progression & DNA replication have been

#Medsky🧪 #immunosky #publichealth #Casereport #Naturalkillercell deficiency (NKD) is a primary immunodeficiency where natural killer cells are affected in the absence of other immune defects . Individuals with NKD present with malignancies & susceptibility to viral infection,

Quite simply, the disinformation spread by RFK Jr and his fellow charlatan’s will hurt more and more children until the burden of misery cannot be ignored by the policy / lawmakers - and the electorate that empowers them.

#Medsky🧪 #Oncosky The study findings suggest that there are therapeutic opportunities to eliminate disseminated tumour cells ( DTCs) , separately from treatments aimed at primary tumours, and GR inhibition is one promising target.
PDF
www.nature.com/articles/s41...

You can't force yourself to feel something you don't feel, but you can force yourself to do what's right despite your feelings.
Pearl S. Buck
🔊

Nocturnal Mind by Yiruma on Apple Music Song · 2019 · Duration 3:14

There is nothing certain, but the uncertain
Music is forever certain
music.apple.com/au/album/noc...

Morning a view from the window

A morning run to get ready for takeoff.

Before the rain, the sky was so blue.

The colours of the morning.

The greatest obstacle to living is expectancy, which hangs upon tomorrow and loses today. The whole future lies in uncertainty: live immediately.
Seneca

A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity - Nature Communications Some patients experience long-lasting symptoms after coronavirus disease (COVID-19). Here the authors report the clinical and laboratory parameters in patients with post-COVID-19 syndrome from a prosp...

pmc.ncbi.nlm.nih.gov/articles/PMC...
@thelancet.com

www.sciencedirect.com/science/arti....

@nature.com
www.nature.com/articles/s41...

pmc.ncbi.nlm.nih.gov/articles/PMC....

(PDF) The fatigue spectrum in a community-based long haul COVID cohort PDF | Introduction In a Long Haul COVID referral clinic we describe the primary presentations of fatigue according to the CDC 2015 criteria for myalgic... | Find, read and cite all the research you ne...

often preventing them from returning to full-time work.
- Risk Factors: Significant predictors for persistent fatigue include female sex, older age, high BMI, and the presence of comorbid depression or anxiety.

www.researchgate.net/publication/...

-Psychiatric Comorbidity: Anxiety and other psychiatric diagnoses are significantly overrepresented in those meeting ME/CFS criteria compared to those without fatigue (58% vs. 38%).
-Functional Impact: ~ 33% of these patients experience significantly restricted physical functioning,

🔑 Findings
-Prevalence: In referral clinics, roughly 73.5% of LC patients present with fatigue as a primary or co-primary complaint.
-🧠Fog: Unlike many other symptoms, "brain fog" does not exclusively map to the severity of fatigue; it is present in ~ 52% of patients across all fatigue categories.

-Stepwise Symptom Progression: Memory disturbances have been identified as the only trait showing a significant "stepwise" ⏫️ in severity across the no-fatigue, non-ME/CFS fatigue & ME/CFS categories.

-Non-ME/CFS Fatigue (79% of fatigued patients): These individuals report moderate-to-severe fatigue but do not consistently meet all auxiliary criteria for ME/CFS. Their symptoms, like PEM or memory disturbances, are often less intense or frequent.

Sleep & Breathing and have categorised this spectrum based on the CDC 2015 criteria:
ME/CFS Phenotype (21% of fatigued patients): Characterised by the three core symptoms,persistent fatigue, PEM) & unrefreshing sleep,plus either cognitive impairment or #orthostaticintolerance.

of fatigue meet the full diagnostic criteria for ME/CFS, mwhile the remaining 79% experience a fatigue phenotype that, while severe, lacks the consistent presence of all ME/CFS-defining symptoms
Studies published in early 2026, such as those in

#Medsky🧪 #Neurosky #IDsky #publichealth Recap: In a community based cohort of LC patients, #fatigue is a clinical spectrum ranging from general persistent tiredness to a debilitating syndrome meeting the criteria for ME/CFS.
Study indicates that ~ 21% of LC with a primary complaint

The Curious Case of the Disappearing Data Last night I tried to access a dataset I’ve used many times before.

A good documentation of COVID history preserving data for posterity before it is vanished substack.com/home/post/p-...

Screw Covid, I'm going to Sturgis. Troy Tassier is a professor of economics at Fordham University and the author of The Rich Flee and the Poor Take the Bus: How Our Unequal Society Fails Us during Outbreaks.

So @troytassier.bsky.social has written up the results from my @yalesph.bsky.social colleague @rafalpx.bsky.social's brand new paper in PLoS Comp Bio. Read it. With a guest appearance by #KristiNoem. troytassier.substack.com/p/screw-covi...

providing a microstructural explanation for #hyposmia seen in patients.
The study also found that reinfection resulted in significantly lower neural damage vs to primary infection & initial exposure provides some level of immune protection against subsequent neuroinflammatory responses

-White Matter Integrity: Diffusion Tensor Imaging (DTI) showed reduced fractional anisotropy (FA) in the #corpuscallosum & #hippocampus, signifying axonal damage & #demyelination.
-The XBB.1 variant caused significant disruption to the olfactory bulb and entorhinal cortex,