Aloysius, Michael

The golden age of vaccine development - Works in Progress Magazine The first vaccine was a lucky accident. Now we can design new vaccines in weeks, atom by atom.

NEW article by me!

We can now visualize pathogens down to atoms; design vaccines in weeks; manufacture them in microbial factories; engineer them more precise than ever before.

We're living through a golden age of vaccine development, but only if we continue to invest in them.

I want to love this because it’s the last generation of big Cadillacs, but front-wheel-drive breaks the nostalgia of classic Cadillacs and the Northstar doesn’t have longevity on its side. I hope someone buys it and keeps it clean. It still feels historic in a way the Escalade never will.

It seems as if there’s a new apartment building going up every time I head downtown, so it’s good to see the economic data indicating the positive benefits.

Every new unit in downtown Raleigh is one less family moving to the suburbs and adding to the sprawl. I’m here for the change.

Crassness aside, it’s the incoherence that offends. If you were judging the character of those two based on sexual ethics, you’d have trump in the tramp column. We deserve wittier opponents.

Let’s talk about sedition and treason, because the most powerful yet inadequate man in the world is having a tantrum about it, and his soulless, spineless sycophants are boosting his message.

/1

We want to speak directly to members of the Military and the Intelligence Community.

The American people need you to stand up for our laws and our Constitution.

Don’t give up the ship.

4-panel vertical comic. (1) 100 Years Ago [two people standing next to bicycle with small car nearby] PERSON 1: It’s too dangerous riding a bike with these cars around. I should get a car, too. (2) 50 Years Ago [two people between smaller car and bigger car] PERSON 2 with short hair: Small cars are less safe in collisions with larger vehicles, so I should get a bigger one. (3) Today [two people between big car and even bigger car] PERSON 1: Everyone has huge SUVs now. If I don’t get the biggest one, I’m putting my family at risk. (4) Soon [two people next to large armored car with spiked clubs attached] PERSON 2: If I don’t install more whirling spike clubs, I’ll be destroyed by all the other drivers who...

Car Size

xkcd.com/3167/

Your annual reminder that US streets and vehicles are generally not designed to keep pedestrians, especially small ones, safe.

So wonderful Halloween is the most likely day you’ll kill a child with your car, and someone will kill a child you care about with theirs.

www.vox.com/future-perfe...

As a kid in the ‘80s I loved all these characters. I think I just happened to be at the right age to not question whether these were they were authentic. It was a developmental suspension of disbelief. Now I find characters like this corny, but I still have nostalgia for Pee-wee and Macho Man.

Everyone who has a stake in America should read pages 96 through 100 of Judge Young's opinion. (I mean, read the whole thing, of course. But those pages are more broadly important.)

Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof; or abridging the freedom of speech, or of the press; or the right of the people peaceably to assemble, and to petition the Government for a redress of grievances.

I haven’t tried one. My moto camp setup includes a “2 plus” tent that’s already bigger than I’d like. If I were looking to keep the bike dry I’d be more inclined to bring along an ultralight bike cover.

Today was a bit of a bear, but that’s why we ride motorcycles.

#MotoSky

The Gold Wheel Club™ showed up to bike night.

#Motosky #BMWMotorrad #ADVRider

I had a 2001 FZ-1 as my daily rider for a number of years. Fantastic motorcycle that was overlooked as time went on. That bike taught me how good an inline four can be.

There is something deeply troubling in the American psyche that extends all the way into the federal government. “He told me he likes seeing me on TV” is the language of a person in an abusive relationship. These are men at the top of the world who are desperate to feel loved.

Donald J. Trump @realDonaldTrump We have completed our very successful attack on the three Nuclear sites in Iran, including Fordow, Natanz, and Esfahan. All planes are now outside of Iran air space. A full payload of BOMBS was dropped on the primary site, Fordow. All planes are safely on their way home. Congratulations to our great American Warriors There is not another military in the World that could have done this. NOW IS THE TIME FOR PEACE! Thank you for your attention to this matter. 773 ReTruths 2.95k Likes Jun 21, 2025 at 6:50 PM

Trump has effectively launched the U.S. into war without congressional approval, without a declaration, and entirely on impulse.

Call your Congressperson and demand Congress to speak out and to take immediate action to stop the U.S. from entering a full-scale war.

Giant ice cube in a rocks glass. Text on the glass says, “The old north state”

I’ve been experimenting with making giant ice cubes for drinks. This one was too big and I had to trim it down to fit in a rocks glass.

This is a really good point and it’s far sharper than the usual critique of bluesky. Most of us are here because we left Musk and Zuckerberg, but that doesn’t mean I want to spend all my time talking about Musk and Zuckerberg. Bluesky needs to become a home for other discussion topics.

Just some creepy armed Mad Max guys trying to gain entry to Dodgers Stadium.

ICE says it wasn’t them. DHS says they were Border Patrol. But honestly who the hell knows? They’ve given permission for any psycho to put on a ski mask, point a gun, grab people & throw them into an unmarked vehicle.

The opinion isn’t really about flags at the White House, it’s about how you feel about trump. The thing about the red herring of the day is that it’s not about the red herring— it’s about the other thing, which is always trump.

I have an opinion about flags at the White House. If you ask around, everyone has an opinion about flags at the White House, or they’ll develop one as soon as they hear the question. If they like trump, they’ll like the idea of more flags at the White House. If not, they won’t.

A screenshot from Donald the Idiot™ highlighting his lack of seriousness, which would disqualify a normal person from holding office.

One of the things I hate about the trump era is these constant red herrings. Every day there is a new topic on which we must express an opinion. The issue is always of low importance and distracts us from what matters. All the chatter around the topic of the day is more noise. This time it’s flags.

That sign is rad and von Haefen is one of the good ones. I heard her speak at a public school event a while back. She shouldn’t have to apologize, but that’s the cost of being in a party of decency.

I don’t know when it’s appropriate to make jokes about this stuff, but this is why you can’t skip lunch.

He should buy ICE and make the dress code a big wet diaper.

A top staffer to Sen. Tina Smith emailed Sen. Mike Lee’s top staffers on Monday about “how much additional pain you’ve caused on an unspeakably horrific weekend”

Full emails below

Some thoughts about the military parade in my hometown of Washington DC today -- specifically, the route. Military parades in DC are quite rare. But when they happen, they have always begun, symbolically and geographically, at the Capitol and moved outward. 1/

You have to add up all the red bars and stack them on top of each other to pay for the green bar.

"We’re no longer interested in finding out the truth. The bamboozle has captured us. It’s simply too painful to acknowledge, even to ourselves, that we’ve been taken. Once you give a charlatan power over you, you almost never get it back."

~ Carl Sagan

This is how I’ve felt since January 6th. I still have strong ideological convictions, but they are superseded by my support for democracy, the rule of law, and basic respect for human dignity. If I’m willing to sacrifice humans, my ideology has become an idol.