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Eric Denovellis

@eric-denovellis

Computational Neuroscience Research Scientist @UCSF Frank Lab https://www.edenovellis.com/ https://github.com/edeno

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12.11.2024
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Latest posts by Eric Denovellis @eric-denovellis

02.03.2026 02:16 πŸ‘ 2246 πŸ” 188 πŸ’¬ 18 πŸ“Œ 6
Axel F meets Samuel Beckett in The Lifestyles of the Rich and Tenured | Statistical Modeling, Causal Inference, and Social Science

Axel F meets Samuel Beckett in The Lifestyles of the Rich and Tenured
statmodeling.stat.columbia.edu/2026/02/25/a...

25.02.2026 14:34 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Leader of Columbia Brain Institute Quits Over Friendship With Epstein The Nobel laureate Richard Axel is not accused of wrongdoing but called his association with Jeffrey Epstein a β€œserious error in judgment.”

Breaking News: The Nobel laureate Richard Axel said he was resigning as co-director of a Columbia brain institute over his friendship with Jeffery Epstein.

25.02.2026 06:00 πŸ‘ 217 πŸ” 81 πŸ’¬ 13 πŸ“Œ 17
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learningfromscratch march 16th, workshop day 1 @ cosyne 2026

Excited to be co-organising a #cosyne2026 workshop with Alison Comrie on 'algorithms for learning from scratch'! With a great line-up of speakers, we'll be tackling the question of what processes enable naive biological & artificial agents to adapt to new situations. Info here: tinyurl.com/4u8enf7k

24.02.2026 18:33 πŸ‘ 48 πŸ” 17 πŸ’¬ 1 πŸ“Œ 0

A lot of 1990s photos of Oasis look like this to me.

16.02.2026 03:54 πŸ‘ 2886 πŸ” 270 πŸ’¬ 38 πŸ“Œ 3
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Get in, dorks. We're ready for round two.

RALLY TO TAKE BACK SCIENCE! πŸ”¬πŸ§ͺ✊
March 7th, 2026 in Washington, DC

Learn more at www.standupforscience.net/ma... (link in our bio.)

28.01.2026 17:00 πŸ‘ 526 πŸ” 257 πŸ’¬ 17 πŸ“Œ 37
Attention-like regulation of theta sweeps in the brain's spatial navigation circuit Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion β€” without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

The hippocampal map has its own attentional control signal!
Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See πŸ“Ή in post 4/6 and preprint here πŸ‘‰
www.biorxiv.org/content/10.6...
🧡(1/6)

28.01.2026 10:03 πŸ‘ 183 πŸ” 62 πŸ’¬ 4 πŸ“Œ 10
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Timeline: How the Shooting of Alex Jeffrey Pretti Unfolded A moment-by-moment analysis of video from the scene shows that Mr. Pretti was already restrained when fatal shots were fired, which appears to contradict the federal government’s account of the event.

Alex Pretti was already restrained when federal agents shot and killed him in Minneapolis, a New York Times analysis of video shows. The footage contradicts the Department of Homeland Security’s account of the shooting.

25.01.2026 16:55 πŸ‘ 2888 πŸ” 933 πŸ’¬ 155 πŸ“Œ 85
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πŸ“£ NeuroDataReHack 2026 applications are open!

Join us July 13-17 at Janelia to explore 450+ open neurophysiology datasets on @dandiarchive.org. Learn to analyze existing data and integrate it into your research.

Free to attend, lodging & meals covered.

Apply by Feb 20: nwb.org/events/hck26...

21.01.2026 23:33 πŸ‘ 1 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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GitHub - thosvarley/syntropy: A python package for information-theoretic analysis of discrete and continuous data. A python package for information-theoretic analysis of discrete and continuous data. - thosvarley/syntropy

Introducing a new scientific computing library: syntropy.
Syntropy is a comprehensive package for information theory, aimed at both theoreticians and data analysts working on discrete, continuous, and mixed data.
1/N
github.com/thosvarley/s...

19.01.2026 15:30 πŸ‘ 33 πŸ” 14 πŸ’¬ 2 πŸ“Œ 0

πŸ“£ Pre-COSYNE Brainhack 2026 – Join Us in Lisbon! 🧠✨
March 10–11, 2026 β€’ Lisbon, Portugal

pre-cosyne-brainhack.github.io/hackathon2026

Kick off COSYNE week with two days of hands-on, team-based hacking around real electrophysiology data!

βœ… Apply now via the event website (limited spots).

09.01.2026 11:09 πŸ‘ 9 πŸ” 6 πŸ’¬ 0 πŸ“Œ 1
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Tolman's Sunburst Maze 80 Years on: A Meta‐Analysis Reveals Poor Replicability and Little Evidence for Shortcutting In 1946, Tolman etΒ al. reported that rats could take a novel shortcut to a goal after training on an indirect route, supporting the Cognitive Map theory. However, a review of subsequent Sunburst maze...

Can humans & animals really use internal maps to take shortcuts?

Tolman famously said yes - based largely on his Sunburst maze.

Our new review & meta-analysis suggests evidence is far weaker than you might think.
πŸ§΅πŸ‘‡ doi.org/10.1111/ejn....

@uofgpsychneuro.bsky.social @ejneuroscience.bsky.social

05.01.2026 19:52 πŸ‘ 135 πŸ” 57 πŸ’¬ 7 πŸ“Œ 11
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CatalystNeuro - Neurophysiology Data & Software Solutions CatalystNeuro empowers neuroscience labs with data standardization, NWB conversions, spike sorting pipelines, and open-source software tools.

πŸŽ‰ NeuroConv 0.9.0 is out!

This release brings:
βœ… Redesigned TIFF converter for multi-file & volumetric data
βœ… Enhanced Miniscope support with auto-aggregation
βœ… NWB file repacking for better compression
βœ… New behavioral data documentation

Read more: catalystneuro.com/blog/neuroco...

14.12.2025 18:39 πŸ‘ 0 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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πŸ§ πŸ“’ New preprint alert

Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧡

#neuroskyence #compneurosky

05.12.2025 20:42 πŸ‘ 72 πŸ” 31 πŸ’¬ 3 πŸ“Œ 1
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Open Data In Neurophysiology: Advancements, Solutions & Challenges Ongoing efforts over the last 50 years have made data and methods more reproducible and transparent across the life sciences. This openness has led to transformative insights and vastly accelerated sc...

Check out our new perspective paper in eNeuro! We explore recent advancements and future prospects in open neuroscience, and discuss how open science practices, data sharing, and structural changes can create a more collaborative and transparent scientific ecosystem

www.eneuro.org/content/12/1...

26.11.2025 22:42 πŸ‘ 1 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Maybe some scientists should have stayed on twitter....

19.11.2025 03:11 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Our new preprint: The primate hippocampus parses experience into event-aligned neural states, creating a temporal scaffold for organizing behavior.

At #SfN25 ? Come chat at my poster β€” Wednesday AM (PP14; 414.03).

17.11.2025 23:30 πŸ‘ 14 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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Sosa Lab - Postdoctoral Researchers We are seeking postdocs to start in 2026!

The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum.

If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...

07.11.2025 22:53 πŸ‘ 78 πŸ” 49 πŸ’¬ 1 πŸ“Œ 1

"doxxing" was named after the first person doxed, Robert Dox, 4520 Jacobs Ave, Belview, MN

21.10.2025 21:28 πŸ‘ 6284 πŸ” 968 πŸ’¬ 54 πŸ“Œ 15
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Want to make publication-ready figures come straight from Python without having to do any manual editing? Are you fed up with axes labels being unreadable during your presentations? Follow this short tutorial including code examples! πŸ‘‡πŸ§΅

16.10.2025 08:26 πŸ‘ 158 πŸ” 46 πŸ’¬ 2 πŸ“Œ 4
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I’m pleased to share our new paper, β€œHippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social !

With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics

02.10.2025 15:46 πŸ‘ 71 πŸ” 28 πŸ’¬ 4 πŸ“Œ 1
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I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!

www.biorxiv.org/content/10.1...

24.09.2025 09:52 πŸ‘ 219 πŸ” 86 πŸ’¬ 9 πŸ“Œ 9

The New York Times piece today about US science is terrible and wrongβ€”in many ways.

I could write a whole article about this, but as one example:

β€œTo close observers, the original crisis began well before any of this…”
No. I’m a close observer of science, and this is incorrect.

22.09.2025 12:20 πŸ‘ 915 πŸ” 224 πŸ’¬ 24 πŸ“Œ 30
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Sosa Lab

The Sosa Lab website is now live!
www.sosaneurolab.com

We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains πŸ”οΈ, please check out the "Join" page.

22.09.2025 21:22 πŸ‘ 93 πŸ” 37 πŸ’¬ 0 πŸ“Œ 0
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1/
🚨 New preprint! 🚨

Excited and proud (& a little nervous πŸ˜…) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. πŸ§΅πŸ‘‡

πŸ“„ www.biorxiv.org/content/10.1...
πŸ’» code + data πŸ”— below 🀩

#neuroskyence

17.09.2025 19:32 πŸ‘ 134 πŸ” 56 πŸ’¬ 10 πŸ“Œ 6

I know there are data repositories like Dandi for ephys, but are there known repositories for behavioral studies? Like where people put trial-wise behavior for individual subjects?

15.09.2025 18:21 πŸ‘ 4 πŸ” 2 πŸ’¬ 2 πŸ“Œ 1
output from a GAM in the linked essay

output from a GAM in the linked essay

Simon Wood, the GOAT of generalized additive models & creator of the mgcv #rstats package, has an Annual Review of Statistics essay on GAMs, available open access #statssky #mlsky

www.annualreviews.org/content/jour...

10.09.2025 02:14 πŸ‘ 90 πŸ” 39 πŸ’¬ 0 πŸ“Œ 1

It’s a death cult and Trump is Jim Jones.

03.09.2025 16:38 πŸ‘ 138 πŸ” 16 πŸ’¬ 8 πŸ“Œ 2

trying this with GPT-5 and charting new frontiers in gaslighting

19.08.2025 13:08 πŸ‘ 221 πŸ” 55 πŸ’¬ 6 πŸ“Œ 9
How We Brought Respectful Debate Back to The Harvard Crimson’s Editorial Board

How We Brought Respectful Debate Back to The Harvard Crimson’s Editorial Board

To us, the solution is deceptively simple. Universities should create environments where students with different views must talk to one another routinely and establish ground rules that ensure they do so without distractions or prejudgment.

Illiberalism on college campuses isn’t inevitable. At The Crimson, it took only a few months to radically improve.

To us, the solution is deceptively simple. Universities should create environments where students with different views must talk to one another routinely and establish ground rules that ensure they do so without distractions or prejudgment. Illiberalism on college campuses isn’t inevitable. At The Crimson, it took only a few months to radically improve.

I will never understand how American elites managed to convince themselves that uncivil debate β€” not fascism, not impunity and not widespread indifference to facts β€” is the defining problem of our time.
www.nytimes.com/2025/08/26/o...

28.08.2025 13:24 πŸ‘ 4676 πŸ” 848 πŸ’¬ 206 πŸ“Œ 209