Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC)
www.nature.com/articles/s41...
Our 2025 Workshop, “Leveraging the Power of Artificial Intelligence to Foster Progress in Immuno-oncology..." educated the IO community to develop new cancer immunotherapies and improve patient care with AI. @jasmineplummer.bsky.social @aruthak.bsky.social @fertiglab.bsky.social @dinler.bsky.social
Very cool talk by @aruthak.bsky.social at #EMBLSpatialBiology!
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪
@natgenet.nature.com
Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer www.nature.com/articles/s41... #SpatialMedicine #PrecisionMedicine #LungCancer @lungfoundation.bsky.social @iaslc.bsky.social
📢The September issue of @natgenet.nature.com is out!
Featuring:
✅multiomic analysis in NSCLC
✅ancestral recombination graphs with SINGER
✅mutational landscape of TNBC in African American women
✅scDNAme&3Dgenome atlas of human SAT
✅avena super-pangenome
&more!
⬇️
www.nature.com/ng/volumes/5...
PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarrays url: academic.oup.com/nargab/artic...
Plasma proteomics offers a non-invasive approach to monitor dynamic changes in tumour and immune signatures in non-small cell lung cancer (NSCLC). www.researchsquare.com/article/rs-7...
Did you catch the Queensland Spatial Biology Centre (QSBC) on Channel 9?
@aruthak.bsky.social shared an exciting world-first discovery! His team has profiled hundreds of proteins & thousands of gene messages from just a single tissue slide, using samples from 84 patients with #headandneckcancer.
Latest news feature in @natbiotech.nature.com on recent developments in spatial biology to unravel disease mechanisms, with insights from experts in field. @aruthak.bsky.social @nebanovich.bsky.social @ai4pathology.bsky.social @jasmineplummer.bsky.social www.nature.com/articles/s41...
A/Prof Arutha Kulasinghe @aruthak.bsky.social from the Queensland Spatial Biology Centre (QSBC) presented his lab's latest research at the SelectScience Cancer Research Summit. Watch the webinar💻 www.selectscience.net/video/deciph...
#cancerresearch #research #spatialbiology #spatialresearch
The QSBC team have presented cutting-edge #cancerresearch findings at the world’s largest #cancer #research conference in Chicago this past week, highlighting how immune cells can block the body’s response to #immunotherapy in aggressive head & neck cancers.
@aruthak.bsky.social
How? SM3DD avoids introducing inaccuracies caused by cell segmentation and the downstream effects of mixed-cell expression profiles that contribute to errors in cell type annotation and differential expression analysis.
We are excited to share that our newest spatial method, SM3DD! This is a cell segmentation / annotation-free approach for interpreting 3D Spatial Transcriptomics. Preprint: www.biorxiv.org/cgi/content/...
Their recent tissue-imaging research reveals how the tumour environment, metabolic activity,& immune cells influence patient survival. This groundbreaking work can pave the way for new therapies for one of the deadliest cancers affecting women and people with ovaries today. (2/4)
🎉New cutting-edge research on ovarian cancer 🎉
Ovarian cancer is one of the deadliest cancers, often detected too late & with few treatment options. But thanks to the work of The University of Queensland's A/Prof @aruthak.bsky.social, Naomi Berrell & their team, there’s new hope on the horizon (1/4)
This stunning image, captured by Queensland Spatial Biology Centre (QSBC) scientists using the Wesley Research Institute Phenocycler, has won the prestigious 2025 National Health and Medical Research Council (NHMRC) Science to Art Award!
@aruthak.bsky.social
#spatialmapping #research #science
Do you want to know how mechanical interaction between tissue layers controls the formation of complex organ shapes in plants? 🔬🌼
🚨Our latest collaborative work with @routierlab.bsky.social is now published @natureplants.bsky.social
Find out more👉 rdcu.be/efad3
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
A/Prof Kulasinghe @aruthak.bsky.social from the Queensland Spatial Biology Centre (QSBC) featured in the Australian Weekend Magazine. He unpacks the advanced imaging techniques utilised by his team, that provide unprecedented insight into immune cells’ responses to cancers. bit.ly/3DOFJdH
Checkout today's issue of The Australian Weekend Magazine!
The inimitable @aruthak.bsky.social !
In a groundbreaking study, researchers from Queensland Spatial Biology Centre have uncovered a crucial factor that determines whether patients with head and neck cancer will respond to immunotherapy. Read the paper translational-medicine.biomedcentral.com/articles/10....
#spatialmapping #research
@aruthak.bsky.social and team at the University of Queensland have performed spatial interaction mapping in head & neck cancer patient samples, using a combination of spatial proteomics from Akoya and Navinci’s isPLA
Read the article here: translational-medicine.biomedcentral.com/articles/10....
🧬 Exciting New #SpatialAnalysis Tool! 🧬
🚀 Introducing PRISM: A powerful Python package for the interactive and integrated analysis of multiplexed tissue microarrays! www.biorxiv.org/content/10.1...
@Aruthak.bsky.social Yes! The #JEDIs are Innovating & JOE YEONG is pulling us together & time not issue 4 this dedicated group still on a hi from #multiomics2024 /10pm #UK, 6am #Singapore & #Taipei, 8am #AU , 2pm #OR #SpatialMedicine #SpatialCatchUps #SpatialInnovation #FinishCancer #cancer
Thanks to @aruthak.bsky.social and colleagues for the invitation to this fantastic, unique meeting #multi-omics2024.
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social
#Multiomics2024 was amazing and I was very proud to be invited to speak for @standardbiology.bsky.social. Here’s the cartoon version.
Huge thanks to @aruthak.bsky.social for bringing it all together. #spatialbio
What an incredible evening at the #MultiOmics2024 Gala Dinner! What I heard aptly described as "the largest convening of kings behind spatial biology and multi-omics—right here in Brisbane!"
Our video was well-recieved #philanthropyinaction
